Chemoprevention of DMBA-induced mammary gland carcinogenesis – preventive effects of free oxygen radical scavengers

Soybir, Gürsel; Köksoy, Ferda Nihat; Koyuncu, Hülya; Yalçın, Orhan; Köse, Hakki; Topuzlu, Cemalettin

doi:10.1023/a:1005701116297

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…However, a critical analysis of data on the treatment of hypertension with these drugs allowed WHO experts to conclude that such information was unreasonable [19][20]. In addition, it was shown that with the introduction of certain carcinogens (7, 12-dimethylbenzantracene) into animals, verapamil suppressed the development of tumors in rats [21]. Other researchers have shown the absence of tumor-stimulating activity of verapamil during prolonged exposure in rats [22].…”

Section: Figure 2 the Ratio Of Blood Cells Aggregation Indicators Unmentioning

confidence: 99%

Treatment of Patients with Glioblastomas by Low Concentrations of Verapamil Hydrochloride in the Late Postoperative Period

Gridina¹,

Morozov²,

Ushenin³

et al. 2019

CRJ

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Antitumor effect of calcium channel blockers low concentrations has been investigated on the example of verapamil hydrochloride in the combined treatment of patients with glioblastomas after operation. Patients, who underwent brain tumor surgery, postoperative radiotherapy and chemotherapy, were divided into two groups. The first group of 11 patients was taken by verapamil -hydrochloride in low concentrations, the second group (32 patients) served as a control. The concentration of the drug was selected individually by means of peripheral blood cells aggregation data on the "Plasmon-6" biosensor. The criterion for the drug concentration selecting was the lowest level of peripheral blood cells aggregation in vitro, reflecting the level of NMDA-dependent calcium channels blocking of the peripheral blood cells membranes. The optimal concentration of verapamil -hydrochloride for all patients was less than 10,000. The criteria of the antitumor activity of verapamil-hydrochloride in low concentrations was the length of the patients life in the postoperative period. When using the drug in patients there were no signs of toxic effects of verapamil -hydrochloride on the body, life expectancy was 10 months more compared to the group of patients not treated with verapamil -hydrochloride and the absence of the toxic and tumorstimulating action of the drug.

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Section: Figure 2 the Ratio Of Blood Cells Aggregation Indicators Unmentioning

confidence: 99%

Treatment of Patients with Glioblastomas by Low Concentrations of Verapamil Hydrochloride in the Late Postoperative Period

Gridina¹,

Morozov²,

Ushenin³

et al. 2019

CRJ

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“…Однако критический анализ данных о лечении гипертонической болезни этими препаратами позволил экспертам ВОЗ сделать заключение о необоснованности таких сведений [17,18]. Кроме того, показано, что при введении в организм животных некоторых канцерогенов (7,12-диметилбензантрацен) верапамил подавлял возникновение опухолей у крыс [19]. Другими исследователями показано отсутствие опухольстимулирующей активности верапамила при длительных воздействиях на крысах [20].…”

Section: Ukrainian Neurosurgical Journal Vol 25 N3 2019unclassified

The first experience of combined treatment of brain malignant gliomas by means of blocking membrane calcium channels

et al. 2019

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Objective. To investigate the antitumor effect of low concentrations of calcium channel blockers on the example of verapamil hydrochloride in the combined treatment of patients with glioblastomas after operation. Materials and methods. Patients who underwent brain tumor surgery, postoperative radiotherapy and chemotherapy were divided into two groups. The first group of 8 patients received verapamil hydrochloride at low concentrations; the second group (32 patients) served as a control group. The drug concentration was selected individually according to peripheral blood cells aggregation data on the "Plasmon-6" biosensor. The criterion for selecting the drug concentration was the lowest level of peripheral blood cells aggregation in vitro, reflecting the level of blocking of NMDA-dependent calcium channels on the membranes of peripheral blood cells. The optimal concentration of verapamil hydrochloride for all patients was less than 10,000

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Kontrowersje wokół długoterminowych badań Gillesa-Erica Séraliniego nad bezpieczeństwem zdrowotnym kukurydzy GMO

Lisowska

Cortez

2014

seb

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At the end of the year 2012, Food and Chemical Toxicology published a long-term study by Seralini et al., describing the safety evaluation of genetically modified NK603 maize and Roundup herbicide. Contrary to previous, short-term studies, this experiment revealed some negative effects of these substances on the health of experimental animals. GM feeds and Roundup generate revenue worth millions of dollars. This may be the reason why Seralini’s paper has became the subject of much heated criticism, mainly from parties linked to business and agro-biotechnology. After one year of debate, the editors of Food Chem Toxicol. decided to retract the paper, an unprecedented event given that the published article was peer-reviewed and there was no evidence of plagiarism or fraud. Here, we stress the results of Seralini’s study, discuss the methodological hints of that work and cite the commentaries on the whole situation.

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Chemoprevention of DMBA-induced mammary gland carcinogenesis – preventive effects of free oxygen radical scavengers

Cited by 3 publications

References 23 publications

Treatment of Patients with Glioblastomas by Low Concentrations of Verapamil Hydrochloride in the Late Postoperative Period

Treatment of Patients with Glioblastomas by Low Concentrations of Verapamil Hydrochloride in the Late Postoperative Period

The first experience of combined treatment of brain malignant gliomas by means of blocking membrane calcium channels

Kontrowersje wokół długoterminowych badań Gillesa-Erica Séraliniego nad bezpieczeństwem zdrowotnym kukurydzy GMO

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