Chemoprevention of cancer: Phenolic antioxidants (BHT, BHA)

G, Hocman

doi:10.1016/0020-711x(88)90158-9

Cited by 108 publications

(67 citation statements)

References 37 publications

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“…The ®nding of an apparent decreased risk with increasing BHA or BHT intake seem to be more in line with the hypothesis that synthetic antioxidants may be protective for cancer and supports ®ndings of studies suggesting that low doses of BHA and BHT inhibit carcinogenesis (Hocman, 1988;Wattenberg, 1986;Williams, 1986;Williams et al, 1999). Antioxidants such as BHA and BHT may have bene®cial e ects by protecting against toxic compounds that are derived from the destruction of nutrients and the oxidation of fatty acids in foods (Grice et al, 1986).…”

Section: Interpretation Of ®Ndingssupporting

confidence: 58%

“…On the other hand, results have also been reported for the carcinogenicity of BHA and BHT in experimental animals (Hocman, 1988;Ito et al, 1983;Williams, 1986). Originally, BHA appeared to have initiating as well as promoting action (Ito et al, 1986b).…”

Section: Introductionmentioning

confidence: 90%

“…When BHT was administered in the diet of mice and rats lung and liver tumours were induced, but there were also studies that reported no increase in tumour incidence were reported (IARC, 1986b). When administered with known mutagens or carcinogens, BHA and BHT either enhanced, inhibited or had no e ect on carcinogenity (Hocman, 1988;IARC, 1986a,b;Wattenberg, 1985Wattenberg, , 1986Wattenberg et al, 1980;Williams, 1986). However, for both BHA and BHT anticarcinogenic e ects were seen at low doses when given prior to and during exposure to carcinogens (Williams and Iatropoulos, 1996;Williams et al, 1999).…”

Section: Interpretation Of ®Ndingsmentioning

confidence: 99%

“…BHA and BHT were observed to act as anticarcinogens in various animal models (Hocman, 1988;Wattenberg, 1972Wattenberg, , 1986Wattenberg et al, 1980;Williams, 1986;Williams and Iatropoulos, 1996). On the other hand, results have also been reported for the carcinogenicity of BHA and BHT in experimental animals (Hocman, 1988;Ito et al, 1983;Williams, 1986).…”

Section: Introductionmentioning

confidence: 96%

“…Moreover, BHA and BHT are synthetic phenolic compounds, which are the two most widely applied synthetic antioxidants that have been used since the 1950s (IARC, 1986a,b). BHA and BHT are present in small amounts in many commercial foods and thus constitute a small fraction of the diet of many people (Hocman, 1988).…”

Section: Introductionmentioning

confidence: 99%

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Intake of butylated hydroxyanisole and butylated hydroxytoluene and stomach cancer risk: results from analyses in the Netherlands Cohort Study

Botterweck

Verhagen²,

Goldbohm³

et al. 2000

Food and Chemical Toxicology

380

188

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AbstractÐBoth carcinogenic and anticarcinogenic properties have been reported for the synthetic antioxidants butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT). The association between dietary intake of BHA and BHT and stomach cancer risk was investigated in the Netherlands Cohort Study (NLCS) that started in 1986 among 120,852 men and women aged 55 to 69 years. A semi-quantitative food frequency questionnaire was used to assess food consumption. Information on BHA or BHT content of cooking fats, oils, mayonnaise and other creamy salad dressings and dried soups was obtained by chemical analysis, a Dutch database of food additives (ALBA) and the Dutch Compendium of Foods and Diet Products. After 6.3 years of follow-up, complete data on BHA and BHT intake of 192 incident stomach cancer cases and 2035 subcohort members were available for case-cohort analysis. Mean intake of BHA or BHT among subcohort members was 105 and 351 "g/day, respectively. For consumption of mayonnaise and other creamy salad dressings with BHA or BHT no association with stomach cancer risk was observed. A statistically non-signi®cant decrease in stomach cancer risk was observed with increasing BHA and BHT intake [rate ratio (RR) highest/lowest intake of BHA=0.57 (95% con®dence interval (CI): 0.25±1.30] and BHT=0.74 (95% CI: 0.38±1.43). In this study, no signi®cant association with stomach cancer risk was found for usual intake of low levels of BHA and BHT. #

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Section: Interpretation Of ®Ndingssupporting

confidence: 58%

Section: Introductionmentioning

confidence: 90%

Section: Interpretation Of ®Ndingsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Intake of butylated hydroxyanisole and butylated hydroxytoluene and stomach cancer risk: results from analyses in the Netherlands Cohort Study

Botterweck

Verhagen²,

Goldbohm³

et al. 2000

Food and Chemical Toxicology

380

188

View full text Add to dashboard Cite

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Evaluation of chemopreventive action of Ginsenoside Rp1

Kumar

Panwar

et al. 2006

BioFactors

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We evaluated the chemopreventive properties of Ginsenoside Rp1 on 7,12-Dimethyl benz (a) anthracene (DMBA) skin papillomagenesis in Swiss albino mice. A significant reduction in values of tumor incidence, tumor burden, and cumulative number of papilloma was observed in mice treated orally with Ginsenoside Rp1 continuously at pre-, peri- and post-initiational stages of papillomagenesis as compared to the control group. Chemopreventive potential of Ginsenoside Rp1 was also observed on the skin metabolizing enzymes in Swiss albino mice. Ginsenoside Rp1 produced a significant elevation in the skin microsomal cytochrome p-450 and cytochrome b5, glutathione S-transferase (GST), reduced glutathione (GSH), glutathione peroxidase (GPX), glutathione reductase (GR), DT-diaphorase, superoxide dismutase (SOD) and catalase levels in the group of mice treated with Ginsenoside Rp1 for seven consecutive days. However, there was significant decrease in lipid peroxidation (LPO) level in Ginsenoside Rp1 treated group.

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Effect of butylated hydroxytoluene on biliineage differentiation of the human HL‐60 myeioblastic leukemia cell

1990

Journal Cellular Physiology

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Butylated hydroxytoluene (BHT), which has both antioxidant and membrane active properties, has been reported to affect cellular differentiation. We studied its effect on the bipotent lineage differentiation of the important HL-60 human myeloblastic leukemia cell line using reduction of nitroblue tetrazolium, cell cycle analysis, population growth rate, monoclonal antibodies, and morphology. BHT markedly accelerated retinoic acid-induced myelocytic differentiation and dihydroxyvitamin D3-induced monocytic differentiation in a concentration and time-dependent manner. Butylated hydroxyanisole (BHA) had a comparable effect. Preincubation with the compounds was not necessary to evoke the acceleration Other antioxidants and inhibitors of eicosanoid synthesis were inactive. We conclude that the important food preservatives BHT and BHA accelerate the kinetics of terminal differentiation of human leukemia and that this effect is likely due at least in part to their membrane active properties.

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Chemoprevention of cancer: Phenolic antioxidants (BHT, BHA)

Cited by 108 publications

References 37 publications

Intake of butylated hydroxyanisole and butylated hydroxytoluene and stomach cancer risk: results from analyses in the Netherlands Cohort Study

Intake of butylated hydroxyanisole and butylated hydroxytoluene and stomach cancer risk: results from analyses in the Netherlands Cohort Study

Evaluation of chemopreventive action of Ginsenoside Rp1

Effect of butylated hydroxytoluene on biliineage differentiation of the human HL‐60 myeioblastic leukemia cell

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