Chemoprevention in Barrett’s Esophagus

Zeb, Muhammad H.; Baruah, Anushka; Kossak, Sarah; Buttar, Navtej

doi:10.1016/j.gtc.2015.02.009

Cited by 7 publications

(9 citation statements)

References 151 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, Moon et al show through pharmacological modifications of the microenvironment or signaling pathways of sensitized cells that they can impact tumorigenesis. This latter finding may help to foster efforts parallel to the preemptive strategies currently under exploration 3–5 to counter the recent rise in EAC incidence 6 .…”

mentioning

confidence: 90%

“…Taken together, the data of Moon et al raise the possibility of pharmacological suppression of either the initiation or progression of mutationally sensitized cells toward ESCC or at least a subset of ESCCs emerging near the gastroesophageal junction. As such, Moon et al is an allusion to potentially exciting directions in EAC that suggest that statins, NSAIDs, and acid suppression may reduce the development of Barrett’s and/or its progression to EAC 3–5 . Coupled with reducing lifestyle risks via weight loss and smoking cessation, one or more of these medications could counter the enormous rise of EAC cases in developed countries over the past several decades.…”

Section: The Sensitizing Model For Esccmentioning

confidence: 99%

“…Coupled with reducing lifestyle risks via weight loss and smoking cessation, one or more of these medications could counter the enormous rise of EAC cases in developed countries over the past several decades. Statins in particular may be particularly effective due to their wide use and association with both lower rates of Barrett’s formation in at-risk patients and remarkable reductions in the progression of Barrett’s to EAC 4,5 .…”

Section: The Sensitizing Model For Esccmentioning

confidence: 99%

See 2 more Smart Citations

Microenvironment meets lineage complexity in junctional tumorigenesis

Xian

McKeon

2019

Nat Commun

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 90%

Section: The Sensitizing Model For Esccmentioning

confidence: 99%

Section: The Sensitizing Model For Esccmentioning

confidence: 99%

See 1 more Smart Citation

Microenvironment meets lineage complexity in junctional tumorigenesis

Xian

McKeon

2019

Nat Commun

View full text Add to dashboard Cite

show abstract

“…Several agents with relatively specific mechanisms of action have been identified for future clinical studies. For example, statins, nonsteroidal anti-inflammatory drugs, proton pump inhibitors, ursodeoxycholic acid and difluoromethylornithine are all promising agents against EAC [85]. However, it is difficult to test their chemopreventive efficacy through randomized clinical trials.…”

Section: Prevention Of Esophageal and Gastric Cardia Cancersmentioning

confidence: 99%

Etiology and Prevention of Esophageal Cancer

Yang

Chen

2016

Gastrointest Tumors

View full text Add to dashboard Cite

Background: Esophageal cancer (EC) occurs commonly, especially in Asia, and is the sixth leading cause of cancer deaths worldwide. Recently, great progress has been made in research on the etiology and prevention of EC. Summary: The major risk factors for esophageal squamous cell carcinoma (ESCC) are tobacco smoking and alcohol drinking, which act synergistically. Dietary parameters, including dietary carcinogens and insufficiency of micronutrients, could also be important risk factors in certain areas. A common etiological factor for both EC and some other cancers are low levels of intake of fruits and vegetables. With improvements in diet and drinking water in developing countries, the incidence of ESCC decreased. However, in economically well-developed countries, the incidence of esophageal adenocarcinoma (EAC) has markedly increased in the past 40 years. The major etiological factor for EAC is gastroesophageal reflux, which is also an etiological factor for gastric cardia adenocarcinoma (GCA). In certain areas of China, the occurrence of GCA is closely related to ESCC. Susceptibility genes for EC are starting to be discovered, and this may help to identify high-risk groups that have more need for preventive measures. Mitigation of the risk factors, early detection and treatment of precancerous lesions are effective approaches for prevention. Smoking cessation, avoidance of excessive alcohol, meat and caloric consumption, increasing physical activity and frequent consumption of vegetables and fruits are prudent lifestyle modifications for the prevention of EC as well as other diseases. Key Message: The etiology of EC includes tobacco smoking, alcohol drinking, low levels of intake of fruits and vegetables as well as gastroesophageal reflux and susceptibility genes. Practical Implications: A healthy lifestyle including smoking cessation, increasing physical activity, consumption of vegetables as well as reduction of alcohol intake and caloric consumption are major approaches to the prevention of EC.

show abstract

“…Using surgical models of gastroesophageal reflux in rats, we have clearly shown that anti‐inflammatory agents have chemopreventive effects on adenocarcinoma . In humans, the use of aspirin or nonsteroidal anti‐inflammatory drugs is associated with lower risk of BE and EAC, although long‐term double‐blind clinical trials are still needed to validate this conclusion . Mechanistically, inflammation is triggered by the release of various immunomodulators when cells are stimulated by reflux.…”

mentioning

confidence: 99%

Contribution of immunomodulators to gastroesophageal reflux disease and its complications: stromal cells, interleukin 4, and adiponectin

Chen

Shaker

et al. 2016

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

Gastroesophageal reflux disease (GERD) has become the most commonly seen gastrointestinal disorder in outpatient clinics. In the United States, around 20% of the general population experience heartburn on a weekly basis. Although clinical complaints can be mild or moderate, patients with GERD may develop further complications, such as peptic strictures, Barrett's esophagus (BE), and even esophageal adenocarcinoma (EAC). Pathologically, GERD is developed as a result of chronic and enhanced exposure of the esophageal epithelium to noxious gastric refluxate. In this review article, we provide an overview of GERD, and then focus on the roles of stromal cells, interleukin 4 (IL-4), and adiponectin in GERD and BE. The importance of inflammation and immunomodulators in GERD pathogenesis is highlighted. Targeting the immunomodulators or inflammation in general may improve the therapeutic outcome of GERD, in particular, in those refractory to proton pump inhibitors.

show abstract

Chemoprevention in Barrett’s Esophagus

Cited by 7 publications

References 151 publications

Microenvironment meets lineage complexity in junctional tumorigenesis

Microenvironment meets lineage complexity in junctional tumorigenesis

Etiology and Prevention of Esophageal Cancer

Contribution of immunomodulators to gastroesophageal reflux disease and its complications: stromal cells, interleukin 4, and adiponectin

Contact Info

Product

Resources

About