Chemometric Analysis of Urinary Volatile Organic Compounds to Monitor the Efficacy of Pitavastatin Treatments on Mammary Tumor Progression over Time

Grocki, Paul; Woollam, Mark; Liu, Shengzhi; Kalra, Maitri; Siegel, Amanda P.; Li, Bai-Yan; Yokota, Hiroki; Agarwal, Mangilal

doi:10.3390/molecules27134277

Cited by 3 publications

(1 citation statement)

References 34 publications

(52 reference statements)

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“…Podolskiy et al [62] analyzed the steroid profile of urine samples by GC-MS and analyzed data by LDA and a neural-network based discriminant analysis to evaluate the degradation of samples for anti-doping analyses. VOC analysis of urine samples was also used to evaluate the efficacy of antitumoral treatment of breast cancer by Grocki et al [63]. Yang et al [64], instead, analyzed urinary samples to evaluate candidate metabolites for the diagnosis of inherit metabolomic diseases.…”

Section: Gas Chromatography (Gc) and Chemometricsmentioning

confidence: 99%

Extracting Information and Enhancing the Quality of Separation Data: A Review on Chemometrics-Assisted Analysis of Volatile, Soluble and Colloidal Samples

et al. 2023

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Instrument automation, technological advancements and improved computational power made separation science an extremely data-rich approach, requiring the use of statistical and data analysis tools that are able to optimize processes and combine multiple outputs. The use of chemometrics is growing, greatly improving the ability to extract meaningful information. Separation–multidetection generates multidimensional data, whose elaboration should not be left to the discretion of the operator. However, some applications or techniques still suffer from the lack of method optimization through DoE and downstream multivariate analysis, limiting their potential. This review aims at summarizing how chemometrics can assist analytical chemists in terms of data elaboration and method design, focusing on what can be achieved by applying chemometric approaches to separation science. Recent applications of chemometrics in separation analyses, in particular in gas, liquid and size-exclusion chromatography, together with field flow fractionation, will be detailed to visualize the state of the art of separation chemometrics, encompassing volatile, soluble and solid (colloidal) analytes. The samples considered will range from food chemistry and environmental chemistry to bio/pharmaceutical science.

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Section: Gas Chromatography (Gc) and Chemometricsmentioning

confidence: 99%

Extracting Information and Enhancing the Quality of Separation Data: A Review on Chemometrics-Assisted Analysis of Volatile, Soluble and Colloidal Samples

et al. 2023

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Canine-Inspired Chemometric Analysis of Volatile Organic Compounds in Urine Headspace to Distinguish Prostate Cancer in Mice and Men

Woollam

Siegel

Munshi

et al. 2023

Cancers

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Canines can identify prostate cancer with high accuracy by smelling volatile organic compounds (VOCs) in urine. Previous studies have identified VOC biomarkers for prostate cancer utilizing solid phase microextraction (SPME) gas chromatography–mass spectrometry (GC-MS) but have not assessed the ability of VOCs to distinguish aggressive cancers. Additionally, previous investigations have utilized murine models to identify biomarkers but have not determined if the results are translatable to humans. To address these challenges, urine was collected from mice with prostate cancer and men undergoing prostate cancer biopsy and VOCs were analyzed by SPME GC-MS. Prior to analysis, SPME fibers/arrows were compared, and the fibers had enhanced sensitivity toward VOCs with a low molecular weight. The analysis of mouse urine demonstrated that VOCs could distinguish tumor-bearing mice with 100% accuracy. Linear discriminant analysis of six VOCs in human urine distinguished prostate cancer with sensitivity = 75% and specificity = 69%. Another panel of seven VOCs could classify aggressive cancer with sensitivity = 78% and specificity = 85%. These results show that VOCs have moderate accuracy in detecting prostate cancer and a superior ability to stratify aggressive tumors. Furthermore, the overlap in the structure of VOCs identified in humans and mice shows the merit of murine models for identifying biomarker candidates.

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Storage of Documents as a Function of Sustainability

Mirković

Bolanča

2023

Sustainability

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Sustainability is a premise that has been implemented in all technologies, industries, and service activities to have as little impact on the environment as possible. Typography as a profession made its contribution by creating eco fonts. In each country, the law regulates the lifespan of the storage of everyday business documents. One of the ways to reduce the impact on the environment is to reduce the consumption of ink, which can be achieved by printing the document with more sustainable fonts. By using the mentioned fonts when creating documents, the user should not notice a visual difference, and the document should have the same level of readability. Earlier research on ecological standards was only related to the environmental acceptability of materials, i.e., inks or printing substrates. Using eco fonts, each ink can have a reduced environmental impact. The more environmentally friendly fonts, Ryman Eco and Ecofont Sans, were tested in this experiment. Arial as a standard sans serif font and Times New Roman as a standard serif font were used as reference fonts. In the research, coverage data of different document samples created with different types of typeface and spacing are interpreted to investigate the possibility of saving ink. As eco fonts have been used since the end of the previous and beginning of this century, some stored documents are certainly ready for waste management, which is almost always recycled. By recycling document samples, the optical characteristics of laboratory paper sheets obtained by chemical deinking flotation were investigated. Another aim of the investigation is to provide insight into the quality of recycled fibres after the recycling process.

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Chemometric Analysis of Urinary Volatile Organic Compounds to Monitor the Efficacy of Pitavastatin Treatments on Mammary Tumor Progression over Time

Cited by 3 publications

References 34 publications

Extracting Information and Enhancing the Quality of Separation Data: A Review on Chemometrics-Assisted Analysis of Volatile, Soluble and Colloidal Samples

Extracting Information and Enhancing the Quality of Separation Data: A Review on Chemometrics-Assisted Analysis of Volatile, Soluble and Colloidal Samples

Canine-Inspired Chemometric Analysis of Volatile Organic Compounds in Urine Headspace to Distinguish Prostate Cancer in Mice and Men

Storage of Documents as a Function of Sustainability

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