Chemometric analysis of screen-printed biosensor chronoamperometric responses

Rojas, Juan; Tachon, A. Fontana; Chevalier, Dominique; Noguer, Thierry; Marty, Jean‐Louis; Ghommidh, Ch

doi:10.1016/j.snb.2004.04.034

Cited by 13 publications

(10 citation statements)

References 37 publications

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“…22 Contributing even more to the versatility of biosensor detection devices, the use of multivariate calibration methods allows the user to obtain additional information about the system under study and to collect information for simultaneous determination of similar compounds. 23 Generalizing, calibration is an operation that, for instance, correlates a signal with an entrance value for a determination system under specific conditions. 24 Calibration is based on the generation of mathematical models correlating the signal of a certain analytical device with a property of interest of the analyzed samples.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Different Phenolic Compounds Using Electrochemical Biosensor and Multivariate Calibration

Dantas

Nogueira

Etchegaray

et al. 2017

J. Braz. Chem. Soc.

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Phenolic compounds are important environmental contaminants due to their high toxicity and persistence in the environment. The use of enzyme-based electrochemical biosensors is a simple, sensitive and low-cost alternative for the determination of these pollutants in contaminated waters. However, in most cases, it is impossible to detect specific compounds in a mixture of phenols due to signal-overlap, as the instruments operate at very close potentials, given that the system is based on a single enzyme to detect similar structures. In order to overcome this problem, in the present work we have successfully used multivariate calibration with partial least squares (PLS) for the simultaneous determination of hydroquinone and guaiacol by a tyrosinase-based biosensor that was assembled using an enzyme extract from yam. The use of PLS allowed us to work with a large number of voltammograms, leading to a single mathematical model for the simultaneous determination of phenols of similar structure in real samples with concentration values of mmol L -1 .

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Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Different Phenolic Compounds Using Electrochemical Biosensor and Multivariate Calibration

Dantas

Nogueira

Etchegaray

et al. 2017

J. Braz. Chem. Soc.

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“…Acceptable models should have low RMSEC and RMSECV and high correlation coefficients. Besides, the differences between RMSECV and PRESS should be small [13, 14]. The parameters of the PLS calibration models are shown in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Application of Multivariate Statistical Analysis to Simultaneous Spectrophotometric Enzymatic Determination of Glucose and Cholesterol in Serum Samples

Torres-Gamez

Rodríguez

Páez-Hernández

et al. 2019

International Journal of Analytical Chemistry

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A method using UV-Vis spectroscopy and multivariate tools for simultaneous determination of glucose and cholesterol was developed in this paper. The method is based on the development of the reaction between the analytes (cholesterol and glucose) and enzymatic reagents. The spectra were analyzed by partial least squares regression and artificial neural networks. The precision estimated between nominal and calculate concentration demonstrate that artificial neural network model was adequate to quantify both analytes in serum samples, since the % relative error obtained was in the interval from 5.1 to 8.3. The proposed model was applied to analyze blood serum samples, and the results are similar compared to those obtained employing the reference method.

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“…PLS has been successfully applied to a microfluidic system with a 1 H NMR-based metabolomic footprint, named as “metabolomics-on-a-chip”, to identify metabolomic markers and to develop a small-molecule toxicity-oriented database. PLS demonstrated to reduce the coefficient of variation for the determination of propionaldehyde in wine from 33 to 15%, using an electrochemical biosensor . The combination of PLS-DA with a microfluidic paper-based device, allowed to overcome the limitation of univariate approaches, that were not able to simultaneously detect acetate, cyanide, fluoride, and phosphate ions in aqueous solution .…”

Section: Discussionmentioning

confidence: 99%

How Can Chemometrics Support the Development of Point of Need Devices?

Tortorella

Cinti

2021

Anal. Chem.

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The necessity to establish novel solutions for decentralized monitoring is attracting attention in all fields of analytical chemistry, i.e., clinical, pharmaceutical, environmental, agri-food. The research around the terms "point-of-need", "point-of-care", "lab-on-chip", "biosensor", "microfluidics", etc. is/has been always aimed at the possibility to produce easy-to-use and fast-response devices to be used by nonspecialists. However, the routes to produce the optimal device might be time-consuming and costly. In this Feature, we would like to highlight the role of chemometric-based approaches that are useful in the conceptualization, production, and data analysis in developing reliable portable devices and also decrease the amount of experiments (thus, costs) at the same time. Readers will be provided a concise overview regarding the most employed chemometric tools used for target identification, design of experiments, data analysis, and digitalization of results applied to the development of diverse portable analytical platforms. This Feature provides a tutorial perspective regarding all the major methods and applications that have been currently developed. In particular, the presence of a concise and informative table assists analytical chemists in utilizing the right chemometrics-based tool depending on the architectures and transduction.

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Chemometric analysis of screen-printed biosensor chronoamperometric responses

Cited by 13 publications

References 37 publications

Simultaneous Determination of Different Phenolic Compounds Using Electrochemical Biosensor and Multivariate Calibration

Simultaneous Determination of Different Phenolic Compounds Using Electrochemical Biosensor and Multivariate Calibration

Application of Multivariate Statistical Analysis to Simultaneous Spectrophotometric Enzymatic Determination of Glucose and Cholesterol in Serum Samples

How Can Chemometrics Support the Development of Point of Need Devices?

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