Chemometric analysis of gas chromatographic peaks measured with a microsensor array: Methodology and performance assessment

Jin, Chunguang; Zellers, Edward T.

doi:10.1016/j.snb.2009.03.010

Cited by 21 publications

(21 citation statements)

References 32 publications

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“…Various MCR algorithms have been introduced and applied, such as AutoBTEM for FT-IR, Raman, and IR imaging data (Xu et al, 2009), PARAFAC for GC×GC-TOFMS (Hoggard et al, 2009 and, Evolving factor analysis (EFA) for hyphenated chromatography-spectrometer methods (Manne, 1995;Maeder, 1987;Gampp et al, 1985), and alternating least square (ALS) for multiple applications (Loszano et al, 2009;Szymanska et al, 2009;Carneiro et al, 2008). The study of Jin and Zellers (2009) was the first to consider using an MCR method to deconvolute overlapping peaks in GC-microsensor array systems.…”

Section: Multivariate Curve Resolutionmentioning

confidence: 99%

“…In their adaptation of such MCR methodology to chromatographic data obtained from microsensor arrays, Jin and Zellers (2009) used experimental sensitivity data derived from a previous study (Zhong, et al, 2007), but the peak shapes, relative responses, and resolutions they examined were generated by simulation assuming idealized Gaussian peaks. Here, the EFA-ALS method has been applied for the first time to a set of experimental data generated from an array of microsensors used as the detector in a µGC.…”

Section: Multivariate Curve Resolutionmentioning

confidence: 99%

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Application of Advanced Sensor Technology to DoD Soil Vapor Intrusion Problems

Reisinger¹,

Burris²,

Zellers³

2012

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The public reporting burden for this coll.etion of infOfmatlon is tstlm attd to av..-a~ 1 hour per response, including the time for reviewing in.ttnJction:, :earching exi:ting data :ourcc:. gathering and maintaining dle data needed, and COt'Tl)letiog and revtewing the collection of information. Send commtntc regarding thic burden utima1e or any other aspect of thic co llection of inform.-bon, including suggestions for reducing the burden, to the Department of Defense. Executive Servitas and Commu nie.ations Oir.etorate (0704•0188). R"pondents c.hould be aware that notwithstanding any othet prov1sion of law, no .,.,uon shall be subject to any penalty fo r failng to comply with a col!ection of information if it does not d isplay a curtentfy valid OMS control number. This study demonstrated the use of a unique prototype gas chromatograph with sensor array detection, the analytical components of which are microfabricated from Si (micro-GC), for analysis of indoor air concentrations of trichloroethylene (TCE) at low-and sub•ppb levels, related to vapor intrusion (VI) applications. The objectives of this study were to demonstrate the performance of the prototype micro-GC in two operating modes: portable mode for forensic and spatial monitoring; and fixedlocation mode for longer term temporal monitoring (exposure estimation). Results from the micro•GC and from T0-15 reference samples were compared. Above the mitigation action level (MAL; 2.3 ppb), the micro-GC accurately determined TCE under complex field matrix conditions. Below the MAL, TCE micro-GC determinations were positively biased due to unresolved interferences. This study stands as the first of its kind, where micro-GC instrumentation was shown capable of sustained, reliable , automated measurements of a trace-level component (TCE) in a complex VOC mixture in real-world environments. 15. SUBJECT TERMS vapor intrusion, micro-gas chromatograph, indoor air analysis 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF a.

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Section: Multivariate Curve Resolutionmentioning

confidence: 99%

Section: Multivariate Curve Resolutionmentioning

confidence: 99%

Application of Advanced Sensor Technology to DoD Soil Vapor Intrusion Problems

Reisinger¹,

Burris²,

Zellers³

2012

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“…3,5,9 However, as with all sorption-based vapor sensor arrays, the diversity of response patterns achievable is quite limited, and the components of VOC mixtures cannot generally be quantitatively determined. [10][11][12][13] This has led to the use of MPN-coated CR arrays as detectors in meso-scale and micro-scale gas chromatographic (GC) instrumentation, [14][15][16][17][18][19][20] which has proven to be quite effective. The small size, low power consumption, simple fabrication and supporting electronics as well as favorable scaling laws favor the use of these devices as mGC detectors.…”

Section: Introductionmentioning

confidence: 99%

A nanoparticle-coated chemiresistor array as a microscale gas chromatograph detector for explosive marker compounds: flow rate and temperature effects

Wright

Zellers

2013

Analyst

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The effects of flow rate and temperature on the performance of a microscale gas chromatographic (μGC) detector consisting of a chemiresistor (CR) array coated with different thiolate-monolayer-protected gold nanoparticles (MPNs) are described with respect to the analysis of three gas-phase markers of the explosive trinitrotoluene (TNT): 2,4-dinitrotoluene (2,4-DNT), 2,6-dinitrotoluene (2,6-DNT), and 2,3-dimethyl-2,3-dinitrobutane (DMNB). In chamber tests, sensors were stable at 70 °C for several days in air, with <2% sensitivity drift per day and virtually no change in the array response patterns. In tests with a conventional upstream GC column, increasing the array temperature from 55-80 °C (1.2 mL min(-1)) led to similar (i.e., 4-6.6-fold) decreases in sensitivity, increases in the limits of detection (LODs), and increases in (estimated) chromatographic resolution. Increasing the flow rate from 1.1-3.7 mL min(-1) (70 °C) led to ∼1.3-2-fold decreases in sensitivity and LOD for 2,4-DNT and 2,6-DNT, a ∼2-fold net increase in LOD for DMNB (passes through a maximum), and a <2-fold increase in resolution. Results indicate that the rates of desorption of the marker vapors out of the MPN films are important determinants of observed trends. With Si-micromachined focuser/injector and separation column devices placed upstream of a CR array held at 70 °C, a mixture of the two primary markers, 2,4-DNT and DMNB, and four similarly volatile alkane interferents was separated in 1.5 min at 3 mL min(-1).

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“…Moreover, these systems can provide a selective detection of a wide range of toxic compounds (Terry et al 1979;Reston and Kolesar 1994;Matzke et al 1998;Wiranto et al 1999;Lambertus et al 2005;Lu et al 2006;Zellers et al 2007;Ohira and Toda 2008;Radadia et al 2008;Jin and Zellers 2009;Zhong et al 2009;Kim et al 2009;Serrano et al 2009). …”

Section: Introductionmentioning

confidence: 99%

A planar micro-concentrator/injector for low power consumption microchromatographic analysis of benzene and 1,3 butadiene

et al. 2012

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In the present study, we present the first steps of the development of a low power consumption GC microsystem for the analysis of benzene in the presence of butadiene, involved in petrochemical industrial applications. This system is made by coupling a low power consumption planar microhotplate based on a preconcentrator with good preconcentration capability and a spiral microchromatographic column that presents a separation capability of both compounds at room temperature, when tested in front of a gas sensor. The first characterization results of the device showed a successful injection of benzene and butadiene when placed in front of the micro-separation module.

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Chemometric analysis of gas chromatographic peaks measured with a microsensor array: Methodology and performance assessment

Cited by 21 publications

References 32 publications

Application of Advanced Sensor Technology to DoD Soil Vapor Intrusion Problems

Application of Advanced Sensor Technology to DoD Soil Vapor Intrusion Problems

A nanoparticle-coated chemiresistor array as a microscale gas chromatograph detector for explosive marker compounds: flow rate and temperature effects

A planar micro-concentrator/injector for low power consumption microchromatographic analysis of benzene and 1,3 butadiene

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