Chemokines in stored platelet concentrates

Bubel, S.; Wilhelm, D.; Entelmann, Mathias; Kirchner, Holger; Klüter, Harald

doi:10.1046/j.1537-2995.1996.36596282589.x

Cited by 106 publications

(100 citation statements)

References 23 publications

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“…Platelets release of chemokines may be one such role, i.e., RANTES is a major chemokine released from concentrated platelet preparation for transfusion and thus might be present in higher concentrations in the SPG-treated supernatant. 31) Furthermore, it is reported that IL-8 receptor exists on platelets. 32) Therefore SPG/SPG-OH-mediated IL-8 synthesis by leukocytes may be due to the synergistic action of the secreted products, RANTES, and membranous receptor, P-selectin, of platelets as well as released IL-8.…”

Section: Discussionmentioning

confidence: 99%

Synergistic Action of .BETA.-Glucan and Platelets on Interleukin-8 Production by Human Peripheral Blood Leukocytes.

Suzuki

Tsuzuki

Ohno

et al. 2002

Biological & Pharmaceutical Bulletin

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b-D-Glucans are major structural components of the fungal cell wall and mainly consist of (1→3)-linked and (1→6)-linked b-D-glucopyranosyl residues.1,2) The ratio of (1→3)-/ (1→6)-linkages and architecture of the b-glucan network vary significantly depending on the species as well as specimens, such as from mycelium, fruit body, and yeast. It is well known that fungal (1→3)-b-D-glucans exhibit various immunomodulating activities, such as antitumor activity, adjuvant activity, hematopoietic activity, complement activation, and cytokine production. [3][4][5][6][7][8] We have been studying the relationship between the structure and activity of fungal b-glucans and suggested that the activity of b-glucan was significantly different depending on the molecular weight, degree of branching, solubility, and conformation. Even though bglucans are the major component of the fungal cell wall, the structure and content of immunomodulating b-glucans are also significantly different depending on the species and specimens. It is difficult to discriminate between the immunomodulating versus inert b-glucans in fungi, and b-glucans may show a variety of immunomodulating spectra. On the other hand, (1→3)-b-D-glucans are detected in the sera of patients with systemic fungal infections and are clinically approved for the diagnostic limulus G test. 9) Recently, several investigators have suggested the presence of the b-glucan receptor on human monocytes and murine peritoneal macrophages, and these proteins could be candidates for the functional b-glucan receptor.10-12) However, this is not sufficient to understand the entire mechanism of b-glucan mediated biological activity because of the diversity of b-glucanmediated activity.Platelets are anucleate blood cells that are required for hemostasis and they participate in pathologic thrombotic syndromes. Platelets are one of the primary defense barriers against the invasion of bacteria and fungi and are important for the induction of inflammatory responses, mediated mainly by preformed granular components such as chemokines, cytokines, growth factors, and microbicidal proteins. 16) It was also demonstrated that this process continues for hours after stimulation with thrombinor integrin-mediated adhesion. It was also reported that human platelets bind to phagocytes via P-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) and modulate the function of these cells, i.e., by cytokine production, superoxide anion production, etc. [17][18][19][20] Elstad et al. suggested that P-selectin primes monocytes for increased platelet-activating factor (PAF) synthesis through regulation of the b-glucan receptor or regulation of signal transduction mechanisms that are linked to the receptor, and that P-selectin expressed on endothelial cells or platelets may serve both to localize monocytes at sites of vascular inflammation or thrombosis and to prime the cells for subsequent responses to augment inflammation. Recently, we have demonstrated that human leukocytes as well as cell lines were activated in...

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Section: Discussionmentioning

confidence: 99%

Synergistic Action of .BETA.-Glucan and Platelets on Interleukin-8 Production by Human Peripheral Blood Leukocytes.

Suzuki

Tsuzuki

Ohno

et al. 2002

Biological & Pharmaceutical Bulletin

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“…Activated platelets produce high quantities of chemokines, especially RANTES (45)(46)(47)(48)(49). Other studies performed by analyzing plasma͞serum levels of ␤-chemokines that did not show a positive effect of chemokines in HIV infection (50)(51)(52)(53)(54)(55)(56) probably were affected by this unspecific release.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous and antigen-induced production of HIV-inhibitory β-chemokines are associated with AIDS-free status

Garzino-Demo

Moss

Margolick

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

129

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The ␤-chemokines RANTES, macrophage inflammatory protein (MIP)-1␣, and MIP-1␤ suppress infection by macrophage-tropic strains of HIV and simian immunodeficiency virus (SIV) by binding and down-regulating the viral coreceptor, CCR5. Accordingly, we have examined whether higher levels of CCR5 ligands are associated with a more favorable clinical status in AIDS. A cross-sectional study of 100 subjects enrolled in the Multicenter AIDS Cohort Study at the Baltimore site was conducted to measure chemokine production and lymphocyte proliferation by peripheral blood mononuclear cells (PBMC). Statistical analyses of the data revealed that the production of HIV-suppressive ␤-chemokines by HIV antigenstimulated PBMC was significantly higher in HIV-positive subjects without AIDS compared with subjects with clinical AIDS. Increased chemokine production was also correlated with higher proliferative responses to HIV antigens. Both parameters were significantly lower in the AIDS versus non-AIDS group. Notably, significantly higher levels of MIP-1␣ were also observed with unstimulated PBMC from seronegative subjects at risk for HIV infection released as compared with seropositive and non-Multicenter AIDS Cohort Study seronegative subjects. The association of chemokine production with antigen-induced proliferative responses, more favorable clinical status in HIV infection, as well as with an uninfected status in subjects at risk for infection suggests a positive role for these molecules in controlling the natural course of HIV infection.lymphocyte proliferation

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“…To date, neither MIP-1a nor MIP-1b serum concentration has ever been correlated with HIV-1-related outcomes, 37 whereas circulating CCL5 (RANTES), especially as measured in plasma depleted of CCL5-rich platelets, 38,39 may be a useful biomarker in HIV-1 patients. 37,40,41 The elevated concentrations of serum CCL5 in our HIV-1-seropositive patients were quite consistent with all earlier observations.…”

Section: African Americans Othersmentioning

confidence: 99%

CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection

et al. 2007

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As members of the chemokine family, macrophage inflammatory protein 1 alpha (MIP-1a) and MIP-1b are unique in that they both consist of non-allelic isoforms encoded by different genes, namely chemokine (C-C motif) ligand 3 (CCL3), CCL4, CCL3-like 1 (CCL3L1) and CCL4L1. The products of these genes and of CCL5 (encoding RANTES, i.e., regulated on activation, normal T expressed and secreted) can block or interfere with human immunodeficiency virus type 1 (HIV-1) infection through competitive binding to chemokine (C-C motif) receptor 5 (CCR5). Our analyses of 411 adolescents confirmed that CCL3 and CCL4 genes occurred invariably as single copies (two per diploid genome), whereas the copy numbers of CCL3L1 and CCL4L1 varied extensively (0-11 and 1-6 copies, respectively). Neither CCL3L1 nor CCL4L1 gene copy number variation showed appreciable impact on susceptibility to or control of HIV-1 infection. Within individuals, linear correlation between CCL3L1 and CCL4L1 copy numbers was moderate regardless of ethnicity (Pearson correlation coefficients ¼ 0.63-0.65, Po0.0001), suggesting that the two loci are not always within the same segmental duplication unit. Persistently low serum MIP-1a and MIP-1b (in the pg/ml range) compared with high CCL5 concentration (ng/ml range) implied that multi-copy genes CCL3L1 and CCL4L1 conferred little advantage in the intensity of expression among uninfected or infected adolescents.

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Chemokines in stored platelet concentrates

Cited by 106 publications

References 23 publications

Synergistic Action of .BETA.-Glucan and Platelets on Interleukin-8 Production by Human Peripheral Blood Leukocytes.

Synergistic Action of .BETA.-Glucan and Platelets on Interleukin-8 Production by Human Peripheral Blood Leukocytes.

Spontaneous and antigen-induced production of HIV-inhibitory β-chemokines are associated with AIDS-free status

CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection

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