Chemokines Ccl17 and Ccl22 in Sarcoidosis

Лазарева, Н. М.; Baranova, Olga; Kudryavtsev, I. V.; Isakov, Dmitry V.; Arsentieva, Natalia A.; Любимова, Н. Е.; Сесь, Т. П.; Ilkovich, Mikhail M.; Тотолян, Арег А.

doi:10.15789/1563-0625-cca-2340

Cited by 2 publications

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“…В настоящее время принято также обращать внимание на потенциальное участие Th2 в гранулемообразовании [42]. Данное предположение подтверждается не только результатами собственных исследований, но и клиническими наблюдениями, которые указывают на прирост уровня CCR4 + CD4 + клеток в периферической крови больных саркоидозом, равно как и на увеличение концентрации хемокина лиганда для этого хемокиного рецептора CCL17 как в сыворотке крови больных [23], так и локально в очаге формирования гранулемы [31]. Более того, в классических экспериментальных работах на in vivo моделях фиброза легких была показана ключевая роль лигандов CCR4 (в первую очередь, CCL17, но и CCL22) в фиброзировании тканей, когда блокада эффектов CCL17 у мышей приводила к уменьшению очага поражения [6].…”

Section: Discussionunclassified

“…thymus and activation-regulated chemokine) и CCL22 или MDC (от англ. macrophage-derived chemokine), уровни которых были повышены в периферической крови больных саркоидозом [23]. Для Th22 характерна не только экспрессия CCR6 и CCR4 на поверхностной мембране, но и наличие CCR10, отвечающего за направленную миграцию клеток в дерму кожи [12].…”

Section: Discussionunclassified

“…Так, для пациентов с хроническим и острым дебютами саркоидоза наблюдалось увеличение доли DP Th17 c 23,72% (19,(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)90) до 31,83% (24,05-41,00) и 36,12% (27,01)) соответственно (в обоих случаях р < 0,001), а также снижения «не классических» Th17 c 45,89% (41,96-51,87) до 34,86% (28,52-43,77) и 41,57% (31,86) соответственно (при р < 0,001 и р = 0,015 соответственно). При остром дебюте заболевания имело место снижение DN Th17 относительно контроля (р = 0,004), тогда как уровень «классических» Th17 был достоверно ниже не только при сравнении с контрольными показателями (18,54% (13,08-27,16) против 24,71% (20,(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)43), р = 0,004), но и значений, полученных для пациентов с хроническим саркоидозом (18,54% (13,08-27,16) против 26,67% (18,(16)(17)…”

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Peripheral blood T helper cell subsets in Löfgren’s and non-Löfgren’s syndrome patients

et al. 2022

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Sarcoidosis is a multisystemic granulomatous disorder of unknown cause, characterized by formation of immune granulomas in various organs, mainly in lungs. Currently, two main phenotypes of pulmonary sarcoidosis are described, i.e., Lofgren’s syndrome (LS) is an acute form with favorable outcome, and non-Lofgren’s syndrome (nLS) is a chronic type of disease with a high risk of pulmonary fibrosis. Our study was aimed to investigate the balance of main “polarized” CD4+ central and effector memory T cells from treatment-naive patients with pulmonary sarcoidosis (LS (n = 19) and nLS (n = 63)) compared to healthy volunteers (HC, n = 48). This marker might be used as immunological markers for predicting severity of this disorder. Multicolor flow cytometry analysis demonstrated that the patients with nLS showed significantly low levels of relative and absolute numbers of CD3+CD4+ lymphocytes if compared to patients with LS and control group (38.94% (31.33-44.24) versus 48.96% (43.34-53.54) and 47.63% (43.82-52.73), p < 0.001 in both cases). Moreover, patients with nLS had reduced frequencies and absolute numbers of “naive”, CM and EM Th cells if compared with healthy controls. Furthermore, the patients with LS showed increased relative and absolute numbers of peripheral blood EM Th cells, capable for migration to peripheral inflamed tissues, when compared with nLS. Finally, patients with LS had increased frequencies and absolute numbers of effector TEMRA Th cells as compared to HC and nLS. Next, significant differences Th1 and Th2 cells frequencies were shown between the patients with nLS and HC (9.64% (7.06-13.65) versus 13.80% (11.24-18.03) with p < 0.001, and 11.96% (9.86-14.78) versus 10.67% (9.13-12.98) with p = 0.048, respectively). But there were no significant differences in the relative numbers of CXCR5-CCR6+Th17 and CXCR5+ follicular T helper cells (Tfh) between the groups. Finally, both groups of patients with pulmonary sarcoidosis contained low proportions of “non-classical” Th17 and DN Th17 cell, but increased levels of DP Th17 cells within total CXCR5-CCR6+ CM Th if compared with HC. Nevertheless, patients with nLS had increased frequency of “classical” Th17 in comparison with healthy controls. A very similar imbalance between different Th17 cell subsets was observed within total CXCR5CCR6+ effector memory Th, that were able to migrate from the bloodstream to the sites of infection, or tissue injury. Taken together, the data suggest that the proportions of Th17 cell subsets in pulmonary sarcoidosis can be evaluated as a diagnostic and/or prognostic marker in clinical practice and these cells could serve as a new therapeutic target.

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Peripheral blood T helper cell subsets in Löfgren’s and non-Löfgren’s syndrome patients

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Autoimmune disorders in patients with granulomatosis diseases after COVID-19: T- and B-cells subsets function

Starshinova,

Kudryavtsev,

Rubinstein

et al. 2024

Russian Journal of Infection and Immunity

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Sarcoidosis and tuberculosis are both granulomatous diseases that have many similarities, making the differential diagnosis of sarcoidosis and tuberculosis difficult, as well as leading to inappropriate treatment selection of both diseases. Autoimmune inflammation (AI) is one of the processes identified tuberculosis and sarcoidosis. Current evidences about the risk and clinical outcomes of COVID-19 infection in patient with sarcoidosis and M. tuberculosis co-infection are still not well understood. SARS-CoV-2 has direct damage to the epithelial cells of the respiratory system, and in-directly due to circulatory disorders. Materials and methods. In the study we analyzed characteristics of autoimmune response in patients with granulomatosis diseases (tuberculosis and sarcoidosis) after COVID-19. We have analyzed articles for the period of December 2019 to March 2023, published in international database (“Medline”, “PubMed”, “Scopus”). The keywords we used “COVID-19”, “SARS-CoV-2”, “tuberculosis”, “sarcoidosis”, “granulomatosis diseases”, “T cells”, “B cells”, “Treg”, “follicular Treg” and “Treg subsets”. The narrative review was carried out in accordance with the PRISMA protocol (http://www.prisma-statement.org) used for this type of study (ID-423604). Results. The influence of COVID-19 infection can also make a significant contribution to the violation of the T- and B-cell immune response, the violation of the nature of cellular metabolism, which will affect the course of granulomatous inflammation in various ways. According to the different researches, autoimmune inflammation can be an important protective mechanism in sarcoidosis and, at the same time, exacerbates the course of tuberculosis infection with the disease progression and pathogen drug resistance formation subsequently. The study of immune response features in patients with COVID-19 showed the presence of several similar characteristics in cellular components of the immune response. Conclusion. Evidence of the presence of autoimmune inflammation in patients with these granulomatous lung diseases, the development of patient immunotypes, including the transferred COVID-19, will be a significant contribution to the development of personalized patient management tactics, taking into account the identified violations of the immune response mechanisms.

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Chemokines Ccl17 and Ccl22 in Sarcoidosis

Cited by 2 publications

References 27 publications

Peripheral blood T helper cell subsets in Löfgren’s and non-Löfgren’s syndrome patients

Peripheral blood T helper cell subsets in Löfgren’s and non-Löfgren’s syndrome patients

Autoimmune disorders in patients with granulomatosis diseases after COVID-19: T- and B-cells subsets function

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