Chemokines as markers of local inflammation and angiogenesis in patients with chronic subdural hematoma: a prospective study

Stanišić, Milo; Lyngstadaas, Ståle Petter; Pripp, Are Hugo; Aasen, Ansgar O.; Lindegaard, Karl-Fredrik; Ivanović, Jugoslav; Ilstad, Eivind; Konglund, Ane; Sandell, Tiril; Ellingsen, Omar; Sæhle, Terje

doi:10.1007/s00701-011-1203-2

Cited by 74 publications

(50 citation statements)

References 60 publications

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“…It is difficult to know the relevance of each individual cytokine as it is well recognised that they work in cascades, influence one another, can compete for receptors and act antagonistically or synergistically. A gross analysis of pro- and anti-inflammatory cytokines in CSDH shows they are both raised in CSDH fluid compared with serum, but that the balance is significantly more pro- than anti-inflammatory [61, 62]. It is important to consider the balance of both the pro- and anti-inflammatory molecules and how this changes over time.…”

Section: Inflammationmentioning

confidence: 99%

“…Both IL-6 and IL-8 have been identified as being significantly elevated in CSDH fluid [53, 61, 73, 74, 80]. More significantly, high levels of these cytokines have been correlated with increased risk of CSDH recurrence and the related imaging features of recurrence [53, 73].…”

Section: Inflammationmentioning

confidence: 99%

“…A lower risk of recurrence has been correlated with increased levels of anti-inflammatory cytokines (e.g. IL-10) [61, 62]. Therefore, overall cytokine profiles certainly appear useful in being able to predict the risk of recurrence.…”

Section: Inflammationmentioning

confidence: 99%

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Pathophysiology of chronic subdural haematoma: inflammation, angiogenesis and implications for pharmacotherapy

Edlmann

Giorgi-Coll

Whitfield

et al. 2017

J Neuroinflammation

417

360

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Chronic subdural haematoma (CSDH) is an encapsulated collection of blood and fluid on the surface of the brain. Historically considered a result of head trauma, recent evidence suggests there are more complex processes involved. Trauma may be absent or very minor and does not explain the progressive, chronic course of the condition. This review focuses on several key processes involved in CSDH development: angiogenesis, fibrinolysis and inflammation. The characteristic membrane surrounding the CSDH has been identified as a source of fluid exudation and haemorrhage. Angiogenic stimuli lead to the creation of fragile blood vessels within membrane walls, whilst fibrinolytic processes prevent clot formation resulting in continued haemorrhage. An abundance of inflammatory cells and markers have been identified within the membranes and subdural fluid and are likely to contribute to propagating an inflammatory response which stimulates ongoing membrane growth and fluid accumulation. Currently, the mainstay of treatment for CSDH is surgical drainage, which has associated risks of recurrence requiring repeat surgery. Understanding of the underlying pathophysiological processes has been applied to developing potential drug treatments. Ongoing research is needed to identify if these therapies are successful in controlling the inflammatory and angiogenic disease processes leading to control and resolution of CSDH.

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Section: Inflammationmentioning

confidence: 99%

Section: Inflammationmentioning

confidence: 99%

See 1 more Smart Citation

Pathophysiology of chronic subdural haematoma: inflammation, angiogenesis and implications for pharmacotherapy

Edlmann

Giorgi-Coll

Whitfield

et al. 2017

J Neuroinflammation

417

360

View full text Add to dashboard Cite

show abstract

“…A similar imbalance between anti- and pro-inflammatory molecules has been found in the CSDH fluid and this imbalance could influence the vascular permeability of the hematoma neomembrane and angiogenesis [7, 8, 44, 45]. Recent reports revealed that inflammatory factors, such as TNF-α, IL-6 and IL-10 are highly expressed in the hematoma fluid of patients with CSDH [44, 46].…”

Section: Introductionmentioning

confidence: 80%

Statins in conditions other than hypocholesterolemic effects for chronic subdural hematoma therapy, old drug, new tricks?

et al. 2017

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Chronic subdural hematoma (CSDH) is one of the most common intracranial hematomas worldwide with a high incidence in the general population. However, the optimum treatment for CSDH is Burr-hole drainage with or without rinse Considering the poor outcomes of CSDH in aged patients, and ambiguous prediction of recurrence in many sides of recurrent CSDHs who have been analyzed, new effective therapies are needed for those CSDHs who are predicated to have poor prognosis for surgery and/or have a higher risk of recurrence. Statins, which is the first-line treatment for patients with high cholesterol and coronary heart disease. However, statins are still not solely limited in the treatment of these diseases. It has been demonstrated that statins could improve CSDH due to its effect of regulation of angiogenesis and inflammation. In this review, in order to provide potential new treatment for CSDH we summarize the recent findings of statins in CSDH in order to try to clarify the mechanisms of this effect.

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“…Some studies of intracranial chronic subdural hematoma found an association with various factors including vascular endothelial growth factor, basic fibroblast growth factor, chemokines, and cytokines. [23][24][25] By clarifying the mechanisms of subdural hematoma formation, we may be able to develop innovative treatments that can prevent chronic hematoma formation and promote tissue healing responses to absorb hematomas within the acute phase.…”

Section: Discussionmentioning

confidence: 99%

Hemorrhagic lumbar facet cysts accompanying a spinal subdural hematoma at the same level

Ikeda

Minami

Yamazaki³

et al. 2014

The Journal of Spinal Cord Medicine

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Context: We present a rare and interesting case of hemorrhagic lumbar facet cysts accompanying a spinal subdural hematoma at the same level suggesting a possible mechanism by which spinal subdural hematomas can arise. Findings: A 71-year-old man presented with persistent sciatic pain and intermittent claudication. Magnetic resonance imaging demonstrated a multilocular mass lesion that showed high signal intensity in both T1-and T2-weighted images, and was located both inside and outside of the spinal canal. Computed tomographic myelography showed a cap-shaped block of the dural tube at L5 and computed tomography with L5-S facet arthrography demonstrated cystic masses. The patient was diagnosed with lumbar radiculopathy caused by hemorrhagic facet cysts, and then progressed to surgical treatment. Surgery revealed that the cysts contained blood clots, and intraoperative findings that the inside of the dural tube appeared blackish and that the dural tube was tensely ballooned after removal of the cysts led us to explorative durotomy. The durotomy demonstrated concentrated old blood pooling both in the dorsal and ventral subdural space, and these spaces were subsequently drained. After surgery, his sciatic pain and intermittent claudication resolved. There was no evidence of cyst mass recurrence at 2 years of follow-up. Conclusion: We propose a newly described mechanism for the formation of spinal subdural hematomas. We recommend surgeons be alert to epidural lesions causing repeated acute compression of the dural tube, which can cause spinal subdural hematoma, and consider the possible coexistence of these lesions in diagnosis and strategic surgical decisions.

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Chemokines as markers of local inflammation and angiogenesis in patients with chronic subdural hematoma: a prospective study

Cited by 74 publications

References 60 publications

Pathophysiology of chronic subdural haematoma: inflammation, angiogenesis and implications for pharmacotherapy

Pathophysiology of chronic subdural haematoma: inflammation, angiogenesis and implications for pharmacotherapy

Statins in conditions other than hypocholesterolemic effects for chronic subdural hematoma therapy, old drug, new tricks?

Hemorrhagic lumbar facet cysts accompanying a spinal subdural hematoma at the same level

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