Chemokines and their receptors in the pathogenesis of allergic asthma: progress and perspective

Bisset, Leslie R.; Schmid‐Grendelmeier, Peter

doi:10.1097/01.mcp.0000144502.50149.e0

Cited by 187 publications

(146 citation statements)

References 82 publications

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“…Chemokines are essential mediators for allergic asthma (1,21,54). The progression of lung chemokine production during the development of allergic airway inflammation is well documented (22,55,56), and the requirement of chemokines MDC, TARC, CXCR2, and CCR6 for disease manifestation has been described previously (29,(31)(32)(33).…”

Section: Discussionmentioning

confidence: 99%

Diverse and Potent Chemokine Production by Lung CD11bhigh Dendritic Cells in Homeostasis and in Allergic Lung Inflammation

Beaty

Rose

Sung

2007

The Journal of Immunology

164

156

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Lung CD11chigh dendritic cells (DC) are comprised of two major phenotypically distinct populations, the CD11bhigh DC and the integrin αEβ7+ DC (CD103+ DC). To examine whether they are functionally distinguishable, global microarray studies and real-time PCR analysis were performed. Significant differences between the two major CD11chigh DC types in chemokine mRNA expression were found. CD11bhigh DC is a major secretory cell type and highly expressed at least 16 chemokine mRNA in the homeostatic state, whereas CD103+ DC highly expressed only 6. Intracellular chemokine staining of CD11chigh lung cells including macrophages, and ELISA determination of sort-purified CD11chigh cell culture supernatants, further showed that CD11bhigh DC produced the highest levels of 9 of 14 and 5 of 7 chemokines studied, respectively. Upon LPS stimulation in vitro and in vivo, CD11bhigh DC remained the highest producer of 7 of 10 of the most highly produced chemokines. Induction of airway hyperreactivity and lung inflammation increased lung CD11bhigh DC numbers markedly, and they produced comparable or higher amounts of 11 of 12 major chemokines when compared with macrophages. Although not a major producer, CD103+ DC produced the highest amounts of the Th2-stimulating chemokines CCL17/thymus and activation-related chemokine and CCL22/monocyte-derived chemokine in both homeostasis and inflammation. Significantly, CCL22/monocyte-derived chemokine exhibited regulatory effects on CD4+ T cell proliferation. Further functional analysis showed that both DC types induced comparable Th subset development. These studies showed that lung CD11bhigh DC is one of the most important leukocyte types in chemokine production and it is readily distinguishable from CD103+ DC in this secretory function.

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Section: Discussionmentioning

confidence: 99%

Diverse and Potent Chemokine Production by Lung CD11bhigh Dendritic Cells in Homeostasis and in Allergic Lung Inflammation

Beaty

Rose

Sung

2007

The Journal of Immunology

164

156

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“…TARC is one of the few chemokines with demonstrable Th2 cell chemoattractant activity (57)(58)(59). We were interested in determining whether the presence of Th2 cytokines (as can occur in an asthmatic's lung or in individuals who have been previously infected with RSV) would have any effect on the production of IP-10 and TARC.…”

Section: The Th2 Cytokines Il-4 and Il-13 Both Significantly Enhance mentioning

confidence: 99%

Respiratory Syncytial Virus Synergizes with Th2 Cytokines to Induce Optimal Levels of TARC/CCL17

Monick

Powers

Hassan

et al. 2007

The Journal of Immunology

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Respiratory syncytial virus (RSV) is a ubiquitous virus that preferentially infects airway epithelial cells, causing asthma exacerbations and severe disease in immunocompromised hosts. Acute RSV infection induces inflammation in the lung. Thymus- and activation-regulated chemokine (TARC) recruits Th2 cells to sites of inflammation. We found that acute RSV infection of BALB/c mice increased TARC production in the lung. Immunization of BALB/c mice with individual RSV proteins can lead to the development of Th1- or Th2-biased T cell responses in the lung after RSV infection. We primed animals with a recombinant vaccinia virus expressing either the RSV fusion (F) protein or the RSV attachment (G) protein, inducing Th1- and Th2-biased pulmonary memory T cell responses, respectively. After RSV infection, TARC production significantly increased in the vaccinia virus G-primed animals only. These data suggest a positive feedback loop for TARC production between RSV infection and Th2 cytokines. RSV-infected lung epithelial cells cultured with IL-4 or IL-13 demonstrated a marked increase in the production of TARC. The synergistic effect of RSV and IL-4/IL-13 on TARC production reflected differential induction of NFκB and STAT6 by the two stimuli (both are in the TARC promoter). These findings demonstrate that RSV induces a chemokine TARC that has the potential to recruit Th2 cells to the lung.

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“…In addition, LPS is a potent inducer of 474 E.L. Thacker CXCL8 [63]. Other chemokines such as CCL2, 3, 4 and 11 have similar functions with monocytes, macrophages, or eosinophils, but less is known about their role in respiratory inflammation in domestic animal species [23]. Research has been performed to investigate the use of anti-CXCL-8 antibodies as an intervention strategy to block neutrophilic infiltration into lung tissues.…”

Section: Chemokinesmentioning

confidence: 99%

Lung inflammatory responses

Thacker

2006

Vet. Res.

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Chemokines and their receptors in the pathogenesis of allergic asthma: progress and perspective

Cited by 187 publications

References 82 publications

Diverse and Potent Chemokine Production by Lung CD11bhigh Dendritic Cells in Homeostasis and in Allergic Lung Inflammation

Diverse and Potent Chemokine Production by Lung CD11bhigh Dendritic Cells in Homeostasis and in Allergic Lung Inflammation

Respiratory Syncytial Virus Synergizes with Th2 Cytokines to Induce Optimal Levels of TARC/CCL17

Lung inflammatory responses

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