Chemokines and atherosclerosis

Reape, Theresa J.; Groot, P.H.E.

doi:10.1016/s0021-9150(99)00346-9

Cited by 452 publications

(316 citation statements)

References 119 publications

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“…Circulating levels of MCP-1 and IL-8 have also been shown to be high in atherosclerosis patients 31 and both chemokines are Chemokines and obesity-related parameters C-S Kim et al implicated in the development of atherosclerosis by stimulating vascular endothelial cells and trafficking macrophages into arterial intima. 13 We also observed that the levels of MCP-1 were negatively correlated to the levels of HDLcholesterol and positively to CRP in obese, and IL-8 showed the similar tendency. Considering the fact that HDLcholesterol or CRP is a strong predictor of cardiovascular disease, 32,33 the chemokines may be implicated in the development of vascular complications in obesity.…”

Section: Discussionsupporting

confidence: 60%

“…11 Chemokines such as MCP-1, IL-8 and leukotactin-1 also play a pivotal role in the development of atherosclerosis by enhancing adhesion molecules on leukocytes and endothelial cells, as well as inducing leukocyte infiltration into the vascular subendothelial area. 13,14 Recent studies have shown that visceral adipose tissue releases more than the subcutaneous and circulating IL-8 is elevated in obesity. 15,16 These findings suggest the possibility that the elevation of chemokines with expanding adiposity contributes to obesity-related pathologies such as diabetes and atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

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Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters

et al. 2006

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Background: Chemotactic cytokines, referred to as chemokines, play an important role in leukocyte trafficking. The circulating levels of chemokines have been shown to increase in inflammatory processes including obesity-related pathologies (e.g. atherosclerosis and diabetes). However, little is currently known about the relationship between chemokines and human obesity. In the present study, we investigated the circulating levels of selected chemokines (monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1a (MIP-1a), leukotactin-1, interleukin-8 (IL-8)) and the association between the chemokine levels and obesity-related parameters: body mass index (BMI), waist circumference, fasting glucose and insulin levels, lipids profile, and the level of C-reactive protein (CRP). Methods: A total of 100 subjects, 50 obese (BMIX25 kg/m 2 ) and 50 who were not obese (BMIo25 kg/m 2 ) participated in the present study. The levels of chemokines and CRP were measured in a fasting state serum by sandwich enzyme-linked immunosorbent assay. Total cholesterol, high-density lipoprotein (HDL)-cholesterol, triglyceride, glucose, and insulin levels were measured by enzymatic analysis and immunoassay. Results: The circulating levels of MCP-1 and IL-8 in the serum were significantly (Po0.05) higher in obese subjects (BMI430 kg/ m 2 ) compared with those of nonobese controls (BMIo25 kg/m 2 ). The levels of CRP were positively correlated with BMI (Po0.001) or waist circumference (Po0.0001). The levels of MCP-1 and IL-8 were positively related to BMI (MCP-1, Po0.02; IL-8, Po0.01) and/or waist circumference (MCP-1, Po0.009; IL-8, Po0.03). The levels of MCP-1 were positively related to the levels of CRP (Po0.007) or interleukin-6 (IL-6) (Po0.0001), and negatively related to the levels of HDL-cholesterol (Po0.01). Homeostasis model assessment (HOMA) score was positively related to the levels of MCP-1 (Po0.02) or IL-8 (Po0.03) in obese subject. Discussion: Our data demonstrated that the circulating levels of MCP-1 and IL-8 are related to obesity-related parameters such as BMI, waist circumference, CRP, IL-6, HOMA and HDL-cholesterol. These findings suggest that the circulating MCP-1 and/or IL-8 may be a potential candidate linking obesity with obesity-related metabolic complications such as atherosclerosis and diabetes.

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Section: Discussionsupporting

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters

et al. 2006

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“…2 migration and proliferation contribute to the pathogenesis of atherosclerosis and restenosis (1)(2)(3). It has been shown that 15-lipoxygenase 1 (15-Lox1) and its murine ortholog 12/15-Lox mediate the oxidation of low density lipoprotein, an important factor in the disease process of atherosclerosis (4,5).…”

Section: Vascular Smooth Muscle Cell (Vsmc)mentioning

confidence: 99%

15-Lipoxygenase-1-enhanced Src-Janus Kinase 2-Signal Transducer and Activator of Transcription 3 Stimulation and Monocyte Chemoattractant Protein-1 Expression Require Redox-sensitive Activation of Epidermal Growth Factor Receptor in Vascular Wall Remodeling

Singh

Wang

Kundumani‐Sridharan

et al. 2011

Journal of Biological Chemistry

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To understand the mechanisms by which 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) activates signal transducer and activator of transcription 3 (STAT3), we studied the role of epidermal growth factor receptor (EGFR). 15(S)-HETEwhereas dominant negative Src blocked BI-induced 15-Lox1-enhanced Jak2 phosphorylation, dnJak2 had no effect on Src phosphorylation. Together, these observations demonstrate for the first time that the 15-Lox1-15(S)-HETE axis activates EGFR via redox-sensitive manner, which in turn mediates Src-Jak2-STAT3-dependent MCP-1 expression leading to vascular wall remodeling.

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“…Accumulated evidence demonstrates that atherosclerosis is closely related to the inflammatory and proliferative responses of the endothelium after injury [1] . During the early stages of atherosclerosis, adhesion molecules, including intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), are secreted by activated endothelial cells in atherosclerotic lesions, stimulating immune cell and monocyte recruitment and migration into the intimal area of the vascular wall [2] . Tumor necrosis factor (TNF)-α, one of the most potent pro-inflammatory cytokines [3] , is critically implicated not only in the induction of endothelial # These authors contributed equally to this work.…”

Section: Introductionmentioning

confidence: 99%

Astragalus polysaccharides suppress ICAM-1 and VCAM-1 expression in TNF-α-treated human vascular endothelial cells by blocking NF-κB activation

et al. 2013

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Aim: To investigate the effects of Astragalus polysaccharides (APS) on tumor necrosis factor (TNF)-α-induced inflammatory reactions in human umbilical vein endothelial cells (HUVECs) and to elucidate the underlying mechanisms. Methods: HUVECs were treated with TNF-α for 24 h. The amounts of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were determined with Western blotting. HUVEC viability and apoptosis were detected using cell viability assay and Hoechst staining, respectively. Reactive oxygen species (ROS) production was measured by DHE staining. Monocyte and HUVEC adhesion assay was used to detect endothelial cell adhesive function. NF-κB activation was detected with immunofluorescence. Results: TNF-α (1-80 ng/mL) caused dose-and time-dependent increases of ICAM-1 and VCAM-1 expression in HUVECs, accompanied by significant augmentation of IκB phosphorylation and NF-κB translocation into the nuclei. Pretreatment with APS (10 and 50 µg/mL) significantly attenuated TNFα-induced upregulation of ICAM-1, VCAM-1, and NF-κB translocation. Moreover, APS significantly reduced apoptosis, ROS generation and adhesion function damage in TNF-α-treated HUVECs. Conclusion: APS suppresses TNFα-induced adhesion molecule expression by blocking NF-κB signaling and inhibiting ROS generation in HUVECs. The results suggest that APS may be used to treat and prevent endothelial cell injury-related diseases.

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Chemokines and atherosclerosis

Cited by 452 publications

References 119 publications

Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters

Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters

15-Lipoxygenase-1-enhanced Src-Janus Kinase 2-Signal Transducer and Activator of Transcription 3 Stimulation and Monocyte Chemoattractant Protein-1 Expression Require Redox-sensitive Activation of Epidermal Growth Factor Receptor in Vascular Wall Remodeling

Astragalus polysaccharides suppress ICAM-1 and VCAM-1 expression in TNF-α-treated human vascular endothelial cells by blocking NF-κB activation

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