Chemokines accentuating protumoral activities in oral cancer microenvironment possess an imperious stratagem for therapeutic resolutions

Panda, Swagatika; Padhiary, Subrat Kumar; Routray, Samapika

doi:10.1016/j.oraloncology.2016.06.008

Cited by 18 publications

(12 citation statements)

References 133 publications

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“…Chemokines can modulate tumor invasion and metastasis by promoting epithelial mesenchymal transition (EMT), upregulating the expression of proteases and downregulating the expression of E-cadherin and integrin through a series of signaling pathways, including the MAPK/ERK/PI3K/ Akt signaling pathways. Furthermore, chemokine receptors expressed by tumor cells can make a response to their corresponding chemokine ligands and migrate directionally towards concentration gradients of chemokine ligands to achieve organ-specific metastases (32,33). Another potential mechanism is that the binding of chemokine ligands to their receptors may induce membrane wrinkling and the formation Chemokine-induced signal transduction in cancer with perineural invasion.…”

Section: Chemokines Promote the Progression Of Cancermentioning

confidence: 99%

Functions of chemokines in the perineural invasion of tumors (Review)

et al. 2018

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The perineural invasion (PNI) of malignant tumors is a form of tumor progression in which cancer cells encroach along nerves. PNI hinders curative resection. Residual tumor cells in or around nerves can bring about local recurrence, infiltration and metastasis. This behavior is usually associated with a poor clinical prognosis. Therefore, it is necessary to investigate novel ligand-receptor crosstalk between nerves and tumor cells that promote the process of PNI. Chemokines are regarded as one of pivotal factors involved in the process of PNI. The present review collates information provided by previous studies with regard to the role of chemokines in PNI. The study presents a definition of PNI in cancer, generalizes the biological characteristics and the expression of chemokines and their receptors in cancer types associated with PNI, and discusses the underlying molecular mechanisms of chemokines, the reciprocal interactions between chemokines and other factors in PNI, and the interconnectivity of the microenvironment and chemokines. The aim of the review is to thoroughly illustrate the molecular cues of chemokines in cancer with PNI and to identify novel antitumor targets.

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Section: Chemokines Promote the Progression Of Cancermentioning

confidence: 99%

Functions of chemokines in the perineural invasion of tumors (Review)

et al. 2018

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“…Several chemokines derived from bone-tropic tumor cells act as osteolytic factors by inducing bone resorption of osteoclasts and promoting the recruitment and differentiation of osteoclast precursors (14)(15)(16), and the levels of these chemokines in serum or bone marrow are associated with cancer-mediated osteolysis in humans (17,18). In the case of OSCC, various chemokines, including CXCL12/CXCR4, CCL5/CCR5, CXCL8, and CCL2, are known to play critical roles in invasion and metastasis by promoting EMT, MMP expression, and cell dissemination (19)(20)(21). OSCC cell-derived CXCL2 and CXCL13 induce RANKL expression in osteoblastic/stromal cells (22,23), and serum levels of CXCL9 and tissue expression of CCL2 are positively correlated with OSCC bone invasion (24,25).…”

Section: Introductionmentioning

confidence: 99%

CCL28-induced RARβ expression inhibits oral squamous cell carcinoma bone invasion

Park¹,

Zhang²,

Lee³

et al. 2019

Journal of Clinical Investigation

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“…Chemokines belong to a superfamily of small molecules (8–14 kDa), which could be classified into the four subfamilies: CXC, CC, C, and CX3C based on the sequence of conserved N-terminal cysteine residues 8 . Many studies have proven that chemokines and chemokine receptors are frequently associated with tumor metastases, such as CXCR4, CCR7 and CCR10 in breast and gastric cancer 9 – 11 , CXCR1 and CXCR5 in pancreatic cancer 12 .…”

Section: Introductionmentioning

confidence: 99%

Up-regulation of chemokine receptor CCR4 is associated with Human Hepatocellular Carcinoma malignant behavior

Cheng

Jin

et al. 2017

Sci Rep

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Studies indicate that the chemokine receptor is responsible for poor prognosis of hepatocellular carcinoma (HCC) patients. In this study, we initially demonstrated that CCR4 is overexpressed in HCC specimens, and its elevation in HCC tissues positively correlates with tumor capsule breakthrough and vascular invasion. Although overexpression of CCR4 failed to influent proliferation of HCC cells in vitro apparently, the prominent acceleration on HCC tumor growth in vivo was remarkable. The underlying mechanism may be involved in neovascularization. Interestingly, different from effect on proliferation, CCR4 overexpression could trigger HCC metastasis both in vitro and in vivo also induced HCC cell epithelial-mesenchymal transition (EMT) as well. Then we identified matrix metalloproteinase 2 (MMP2) as a direct target of CCR4 which plays an important role in CCR4-mediated HCC cell invasion, which was up-regulated by ERK/AKT signaling. Positive correlation between CCR4 and MMP2 expression was also observed in HCC tissues. In conclusion, our study suggested that chemokine receptor CCR4 promotes HCC malignancy and facilitated HCC cell metastases via ERK/AKT/MMP2 pathway. These findings suggest that CCR4 may be a potential new diagnostic and prognostic marker in HCC, and targeting CCR4 may be a potential therapeutic option for blocking HCC metastasis.

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Chemokines accentuating protumoral activities in oral cancer microenvironment possess an imperious stratagem for therapeutic resolutions

Cited by 18 publications

References 133 publications

Functions of chemokines in the perineural invasion of tumors (Review)

Functions of chemokines in the perineural invasion of tumors (Review)

CCL28-induced RARβ expression inhibits oral squamous cell carcinoma bone invasion

Up-regulation of chemokine receptor CCR4 is associated with Human Hepatocellular Carcinoma malignant behavior

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