Chemokine receptors: Key for molecular imaging of inflammation in atherosclerosis

Liu, Yongjian; Woodard, Pamela K.

doi:10.1007/s12350-018-1248-1

Cited by 10 publications

(5 citation statements)

References 18 publications

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“… (3) Inflammation-related studies. Since atherosclerosis is a chronic inflammatory disease, vulnerable plaques are also associated with inflammation; many studies focus on targeting vascular inflammatory cells to study the effects and mechanisms of inflammation inhibition or reversal ( Liu and Woodard, 2019 ; Xie et al, 2020 ; Sammartino et al, 2023 ). (4) PET-related studies.…”

Section: Discussionmentioning

confidence: 99%

Molecular imaging research in atherosclerosis: A 23-year scientometric and visual analysis

Pan

Chen

et al. 2023

Front. Bioeng. Biotechnol.

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Background: Cardiovascular and cerebrovascular diseases are major global health problems, and the main cause is atherosclerosis. Recently, molecular imaging has been widely employed in the diagnosis and therapeutic applications of a variety of diseases, including atherosclerosis. Substantive facts have announced that molecular imaging has broad prospects in the early diagnosis and targeted treatment of atherosclerosis.Objective: We conducted a scientometric analysis of the scientific publications over the past 23 years on molecular imaging research in atherosclerosis, so as to identify the key progress, hotspots, and emerging trends.Methods: Original research and reviews regarding molecular imaging in atherosclerosis were retrieved from the Web of Science Core Collection database. Microsoft Excel 2021 was used to analyze the main findings. CiteSpace, VOSviewer, and a scientometric online platform were used to perform visualization analysis of the co-citation of journals and references, co-occurrence of keywords, and collaboration between countries/regions, institutions, and authors.Results: A total of 1755 publications were finally included, which were published by 795 authors in 443 institutions from 59 countries/regions. The United States was the top country in terms of the number and centrality of publications in this domain, with 810 papers and a centrality of 0.38, and Harvard University published the largest number of articles (182). Fayad, ZA was the most productive author, with 73 papers, while LIBBY P had the most co-citations (493). CIRCULATION was the top co-cited journal with a frequency of 1,411, followed by ARTERIOSCL THROM VAS (1,128). The co-citation references analysis identified eight clusters with a well-structured network (Q = 0.6439) and highly convincing clustering (S = 0.8865). All the studies calculated by keyword co-occurrence were divided into five clusters: “nanoparticle,” “magnetic resonance imaging,” “inflammation,” “positron emission tomography,” and “ultrasonography”. Hot topics mainly focused on cardiovascular disease, contrast media, macrophage, vulnerable plaque, and microbubbles. Sodium fluoride ⁃PET, targeted drug delivery, OCT, photoacoustic imaging, ROS, and oxidative stress were identified as the potential trends.Conclusion: Molecular imaging research in atherosclerosis has attracted extensive attention in academia, while the challenges of clinical transformation faced in this field have been described in this review. The findings of the present research can inform funding agencies and researchers toward future directions.

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Section: Discussionmentioning

confidence: 99%

Molecular imaging research in atherosclerosis: A 23-year scientometric and visual analysis

Pan

Chen

et al. 2023

Front. Bioeng. Biotechnol.

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“…Modified peptides targeting chemokine receptors are also gaining interest as key targeting moieties for in vivo diagnostic imaging [77], as demonstrated by NP surface linking of d-Ala-peptide T-amide (DAPTA) peptides [78][79][80][81]. Detering et al [78] recently showed that polymer NPs functionalized with the CCR5 targeting peptide DAPTA can precisely detect CCR5 along the progression of atherosclerotic lesions.…”

Section: Figure 1 Schematic Representation Of Cellular Targeting Expl...mentioning

confidence: 99%

Chemokines and nanomaterials: interaction for useful immune-applications

Bardi

2022

Explor Immunol

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Chemokines are homeostatic or inflammatory small proteins regulating immune cell migration and are structurally characterized by cysteine disulfide bridges. Around 50 human chemokines binding almost 20 seven-transmembrane G-protein coupled receptors have been discovered. The finding that two of them were the main human immunodeficiency virus (HIV) co-receptors intensified the research on the binding mechanism to block the viral entrance. Blockade of chemokine/chemokine receptor signaling ultimately modulates cell migration, then immune responses. Particular nanotechnologies can be designed to interfere with chemokine signaling or to exploit the ligand-receptor interaction. Surface chemical modification of nanomaterials with chemokines or specific peptides can find several applications in bio-medicine, from tissue-specific drug delivery to reduced cell migration in pathological conditions. Recent highlights on peculiar chemokine-nanoparticle design and their potential to modulate immune responses will be discussed.

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“…In addition, studies with 64 Cu-DOTA-vMIP-II demonstrated an increased CXCR4 expression on plaque margins experiencing a high degree of endothelial dysfunction, thus exposing this tracer as a diagnostic tool for injuries to the endothelium [171]. Other chemokine receptors exploited for imaging of atherosclerotic lesions include CCR5 and CCR2 [172]. Wei et al established the CCR5-specific SPECT tracer 111 In-DOTA-DAPTA [168].…”

Section: Imaging As a Diagnostic Tool In Atherosclerosismentioning

confidence: 99%

Key Chemokine Pathways in Atherosclerosis and Their Therapeutic Potential

Márquez

Vorst

Maas

2021

JCM

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The search to improve therapies to prevent or treat cardiovascular diseases (CVDs) rages on, as CVDs remain a leading cause of death worldwide. Here, the main cause of CVDs, atherosclerosis, and its prevention, take center stage. Chemokines and their receptors have long been known to play an important role in the pathophysiological development of atherosclerosis. Their role extends from the initiation to the progression, and even the potential regression of atherosclerotic lesions. These important regulators in atherosclerosis are therefore an obvious target in the development of therapeutic strategies. A plethora of preclinical studies have assessed various possibilities for targeting chemokine signaling via various approaches, including competitive ligands and microRNAs, which have shown promising results in ameliorating atherosclerosis. Developments in the field also include detailed imaging with tracers that target specific chemokine receptors. Lastly, clinical trials revealed the potential of various therapies but still require further investigation before commencing clinical use. Although there is still a lot to be learned and investigated, it is clear that chemokines and their receptors present attractive yet extremely complex therapeutic targets. Therefore, this review will serve to provide a general overview of the connection between various chemokines and their receptors with atherosclerosis. The different developments, including mouse models and clinical trials that tackle this complex interplay will also be explored.

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Chemokine receptors: Key for molecular imaging of inflammation in atherosclerosis

Cited by 10 publications

References 18 publications

Molecular imaging research in atherosclerosis: A 23-year scientometric and visual analysis

Molecular imaging research in atherosclerosis: A 23-year scientometric and visual analysis

Chemokines and nanomaterials: interaction for useful immune-applications

Key Chemokine Pathways in Atherosclerosis and Their Therapeutic Potential

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