Chemokine receptor 4 expression is correlated with the occurrence and prognosis of gastric cancer

Abstract

Gastric cancer (GC) is a common tumor with a low 5‐year survival rate. The chemokine receptor 4 (CXCR4) protein contributes to the progression and prognosis of GC, but the relationship between CXCR4 and immune infiltration, somatic copy number alteration (SCNA), tumor purity, tumor mutation burden (TMB), cytolytic activity (CYT), and drug sensitivity in GC is poorly understood. This study aimed to systematically explore the role of CXCR4 in GC. Microarray and RNA‐seq data were collected from the Gene Expression Omnibus and The Cancer Genome Atlas. Our analysis shows that CXCR4 is correlated with various types of immune cells. Patients with high CXCR4 expression had a higher fraction of B cells and CD8+ T cells, and a lower fraction of CD4+ T cells. In addition, high CXCR4 expression was associated with more advanced tumor stage, worse prognosis and higher stromal score, immune score, and cytolytic activity (P < 0.05). High CXCR4 expression also correlated with lower tumor purity and TMB. In summary, our analyses suggest that CXCR4 may affect the progression and prognosis of GC by influencing immune infiltration, TMB, CYT, tumor purity, and drug sensitivity.

High expression of TREM2 promotes EMT via the PI3K/AKT pathway in gastric cancer: bioinformatics analysis and experimental verification

“…The link between inflammation and GC has been confirmed in many experiments [55]. For example, inflammation-related factors, consist of T lymphocytes, macrophages, cytokines, and pro-inflammatory chemokines, can promote the development of HP related GC [48,56]; Inflammatory fraction is associated with the prognosis of GC [57]; In addition, amplification of inflammatory response can advance the occurrence of GC in the animal model [58]. The above results are consistent with our idea inflammation related gene TREM2 can affects the malignant phenotype of gastric cancer.…”

Three Genes Predict Prognosis in Microenvironment of Ovarian Cancer

“…SCNA of GYPC was downregulated in various immune cells, and arm-level gain of GYPC was associated with neutrophils and dendritic cells ( Figures 5D,E ). CXCR4 was related to altered immune cells, which can affect the prognosis of gastric cancer ( Li et al, 2020 ). A previous study showed that CXCR4 was upregulated in naive CD4+ and CD8+ T cells and CD4+ central memory T cells, which have a crucial role in modulating immune dysfunction ( Ramonell et al, 2017 ).…”

The Role of Chemokines in the Development of Gastric Cancer—Diagnostic and Therapeutic Implications

“…Some clinical investigations have indicated the significance of the aberrant expression of chemokine receptors in GC, including copy number changes or upregulation of chemokine receptors mRNA. In recent years, several cancer parameters, such as immune infiltration, somatic copy number alterations (SCNA), tumor mutation burden (TMB), tumor purity, cytolytic activity (CYT), and drug sensitivity have been reported to be prognostic factors and potential therapeutic markers for various cancers, including GC [ 44 , 45 ]. There was a statistically significant correlation between CXCR4 levels and TMB, CYT, tumor purity, tumor immune infiltration, and drug sensitivity.…”

“…There was a statistically significant correlation between CXCR4 levels and TMB, CYT, tumor purity, tumor immune infiltration, and drug sensitivity. Moreover, elevated CXCR4 expression can affect the resistance of cancer cells to drugs [ 44 ]. What is more, a possible link between tumor immunity and aberrant expression of CCR4 in GC cells has been proved [ 46 ].…”