Chemokine neutralization as an innovative therapeutic strategy for atopic dermatitis

Abboud, Dayana; Hanson, Julien

doi:10.1016/j.drudis.2016.11.023

Cited by 20 publications

(12 citation statements)

References 58 publications

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“…These chemokines will bind to corresponding receptors and attract more circulating immune cells into inflamed skin [22,24,26,34]. We have summarized the receptors and key functions of these chemokines in the context of AD milieus in Table 1, partly refers to two articles [35,36]. In general, upon TLR2 activation, CCL5, CCL8, and CCL13 Mann-Whitney U test was applied to compare the significant difference between two groups.…”

Section: Discussionmentioning

confidence: 99%

Enhancement of Chemokine mRNA Expression by Toll-Like Receptor 2 Stimulation in Human Peripheral Blood Mononuclear Cells of Patients with Atopic Dermatitis

Lin

Cai

et al. 2020

BioMed Research International

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Atopic dermatitis (AD) is a chronic inflammatory skin disease which is often associated with Staphylococcus aureus (S. aureus) colonization. S. aureus ingredients are potential ligands to activate the Toll-like receptor 2 (TLR2) and drive inflammatory cytokine or chemokine production. However, the role of TLR2-mediated chemokine expression in AD development has not been systematically investigated. In this study, we sought to determine the mode of TLR2-mediated chemokine expression in AD patients. Human peripheral blood mononuclear cells (PBMCs) were isolated from AD patients and healthy controls. Upon incubation with TLR2 ligands Pam3CSK4 and PGN, mRNA expression of chemokines, including CCL1, CCL5, CCL8, CCL13, CCL17, CCL18, CCL22, and CCL27, were determined by quantitative real-time polymerase chain reaction (qRT-PCR) analysis. The results showed that basal mRNA expression of CCL17 in PBMCs from AD patients was upregulated compared with healthy controls, while those of CCL8 and CCL13 were downregulated. When stimulated with TLR2 ligands, the mRNA expression of CCL5, CCL8, CCL13, CCL18, and CCL22 in PBMCs from AD patients was significantly higher than those from healthy controls. The different basal chemokine mRNA expression profiles indicate the different immune status in patients with AD compared with healthy controls. Excessive chemokine mRNA expression induced by TLR2 activation is associated with the development of AD.

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Section: Discussionmentioning

confidence: 99%

Enhancement of Chemokine mRNA Expression by Toll-Like Receptor 2 Stimulation in Human Peripheral Blood Mononuclear Cells of Patients with Atopic Dermatitis

Lin

Cai

et al. 2020

BioMed Research International

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“…mDCs that have been stimulated with TSLP can initiate the development and expansion of inflammatory Th2 cells through the expression of OX40L and can recruit memory Th2 cells through the CCL17 secretion . Thus, OX40L and CCL17 are key molecules in triggering and maintaining the inflammatory Th2 response in the allergic cascade and could be new targets for the treatment of allergic diseases . Although there is evidence indicating that statins have anti‐inflammatory effects on macrophages or monocyte‐derived DCs , there are no studies describing their effects on blood mDCs.…”

Section: Discussionmentioning

confidence: 99%

Statins can suppress DC‐mediated Th2 responses through the repression of OX40‐ligand and CCL17 expression

et al. 2019

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DCs and epithelial cell‐derived thymic stromal lymphopoietin (TSLP) have pivotal roles in allergic inflammation. TSLP stimulates myeloid DCs to express OX40‐ligand (OX40L) and CCL17, which trigger and maintain Th2 cell responses. We have previously shown that statins, which are HMG‐CoA reductase inhibitors, have the ability to suppress type I IFN production by plasmacytoid DCs. Here, we extended our previous work to examine the immunomodulatory effect of statins on allergic responses, particularly the TSLP‐dependent Th2 pathway induced by myeloid DCs. We found that treatment of TSLP‐stimulated DCs with either pitavastatin or simvastatin suppressed both the DC‐mediated inflammatory Th2 cell differentiation and CRTH2+CD4+ memory Th2 cell expansion and also repressed the expressions of OX40L and CCL17 by DCs. These inhibitory effects of statins were mimicked by treatment with either a geranylgeranyl‐transferase inhibitor or Rho‐kinase inhibitor and were counteracted by the addition of mevalonate, suggesting that statins induce geranylgeranylated Rho inactivation through a mevalonate‐dependent pathway. We also found that statins inhibited the expressions of phosphorylated STA6 and NF‐κB‐p50 in TSLP‐stimulated DCs. This study identified a specific ability of statins to control DC‐mediated Th2 responses, suggesting their therapeutic potential for treating allergic diseases.

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“…79 And more notably, dendrimers have also been used as vehicles for both imaging agents and therapeutic materials. 105 For example, Luong et al 106 designed a theranostic nanocarrier consisting of superparamagnetic iron oxide nanoparticle (SPION) core and FA-PAMAM dendrimer surface. Further to increase its therapeutic potentials, an anticancer agent 3,4-difluorobenzylidene-curcumin (CDF) was loaded in …”

Section: Dendrimers As Imaging Agentsmentioning

confidence: 99%

A review of molecular imaging of atherosclerosis and the potential application of dendrimer in imaging of plaque

Anwaier

Chen

Cao

et al. 2017

IJN

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Despite the fact that technological advancements have been made in diagnosis and treatment, cardiovascular diseases (CVDs) remain the leading cause of mortality and morbidity worldwide. Early detection of atherosclerosis (AS), especially vulnerable plaques, plays a crucial role in the prevention of acute coronary syndrome (ACS). Targeting the critical cytokines and molecules that are upregulated during the biological process of AS by in vivo molecular imaging has been widely used in plaque imaging. With their three-dimensional architecture, composition, and abundant terminal functional groups, dendrimers provide a platform for multitargeting and multimodal imaging. Thus, modified dendrimers with the key molecules upregulated in AS plaques will be an innovative attempt to achieve targeted imaging of AS plaques specifically and efficiently. This review was aimed to address some recent works on imaging of AS plaques using various types of image technology and further discuss the applications of dendrimers, an innovative yet seldom used method in imaging of AS plaques due to some limitations and challenges, and we highlight the bright future of the modified dendrimers in characterizing AS plaques.

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Chemokine neutralization as an innovative therapeutic strategy for atopic dermatitis

Cited by 20 publications

References 58 publications

Enhancement of Chemokine mRNA Expression by Toll-Like Receptor 2 Stimulation in Human Peripheral Blood Mononuclear Cells of Patients with Atopic Dermatitis

Enhancement of Chemokine mRNA Expression by Toll-Like Receptor 2 Stimulation in Human Peripheral Blood Mononuclear Cells of Patients with Atopic Dermatitis

Statins can suppress DC‐mediated Th2 responses through the repression of OX40‐ligand and CCL17 expression

A review of molecular imaging of atherosclerosis and the potential application of dendrimer in imaging of plaque

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