Chemokine IP-10 is correlated with cardiac responses and status of infection with HIV and HCV in methadone maintenance patients

Liu, Sheng Wen; Liu, Yu Li; Hwang, Ling Ling; Wang, Sheng Chang; Kuo, Hsu-Ko; Wu, Shiow Ling; Dai, Yu; Liu, Shu Chih; Ho, Ing K.; Chen, Andrew C. H.; Hsiao, Chin Fu; Tsou, Hsiao-Hui

doi:10.1016/j.ijcard.2015.05.055

Cited by 3 publications

(7 citation statements)

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“…High plasma or serum IP-10 was found in patients with lymphoproliferative disorder [ 11 ], systemic lupus erythematosus [ 12 ], HIV infection [ 16 ], or Kawasaki disease of acute vasculitis [ 15 ]. We previously also reported a high plasma IP-10 level in the MMT patients with HIV and HCV infection [ 5 ]. In the present study, we identified a pathway with genome-wide significance and pinpointed a candidate gene correlating the plasma levels of IP-10 in MMT patients.…”

Section: Discussionmentioning

confidence: 99%

“…We previously reported an elevated plasma IP-10 levels in MMT patients with HIV and HCV infection [ 5 ]. In this study, MMT patients without HIV or HCV infection also had a high plasma IP-10 level than the normal controls ( S3 Table ).…”

Section: Discussionmentioning

confidence: 99%

“…The clinical characteristics and methadone treatment courses, including the dose and treatment duration, and the treatment adherence over the previous week, were obtained from patients’ medical records. All the assessments including plasma IP-10 levels were reported in our previous study [ 5 ]. Chemokines IP-10 levels were determined using the Milliplex® MAP human cytokine/chemokine kit (Millipore, Billerica, MA).…”

Section: Methodsmentioning

confidence: 99%

“…We previously reported a high prevalence of hepatitis C viral (HCV, 95%) and human immunodeficiency virus (HIV, 23%) infection in a methadone maintenance treatment (MMT) population in Taiwan [ 4 ]. These HCV or HIV patients showed an increase in plasma levels of chemokine interferon gamma-inducible protein 10 (IP-10; also called chemokine CXC motif ligand 10; CXCL10) [ 5 , 6 ]. IP-10 is a chemoattractant of proinflammatory mediator for T cell activation and adhesion to endothelial cells [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…IP-10 is a chemoattractant of proinflammatory mediator for T cell activation and adhesion to endothelial cells [ 7 , 8 ]. High plasma IP-10 level correlated with the prolonged electrocardiogram (ECG) QTc interval, a potentially lethal side effect of methadone [ 9 , 10 ], in these patients [ 5 ]. High plasma IP-10 level is also associated with other inflammatory diseases.…”

Section: Introductionmentioning

confidence: 99%

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Missense mutation at CLDN8 associated with a high plasma interferon gamma-inducible protein 10 level in methadone-maintained patients with urine test positive for morphine

et al. 2017

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We previously reported a high plasma chemokine interferon gamma-inducible protein 10 (IP-10) level and prolonged electrocardiography QT-interval in methadone maintenance treatment (MMT) patients with HIV or HCV infection. The purpose of this study was to evaluate the genetic association of high plasma IP-10 level in the MMT patients. The gene-based and pathway-based association analyses were conducted using a genome-wide association study dataset in 344 MMT patients for identifying genes and pathways associated with plasma IP-10 level. We found that plasma IP-10 level was significantly associated with a pathway in the tight junction (P = 1.01x10-5), where the claudin 8 (CLDN8) gene had the most significant association (P = 6.8x10-5). A functional single nucleotide polymorphism (SNP) rs686364 at exon 1 of CLDN8 showed strong association with plasma IP-10 levels, in the MMT subjects with positive urine test for morphine (dominant model, P = 0.00004). The minor allele type carriers had higher plasma IP-10 levels than the major allele type carriers. Our data support that the tight junction protein claudin 8 exon 1 is a predictor for the plasma levels of IP-10 in MMT patients with urine test positive for morphine.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Missense mutation at CLDN8 associated with a high plasma interferon gamma-inducible protein 10 level in methadone-maintained patients with urine test positive for morphine

et al. 2017

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APBB2 is associated with amphetamine use and plasma beta-amyloids in patients receiving methadone maintenance treatment

Liu

Fang

Liu

et al. 2018

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Pharmacogenomics study on cadherin 2 network with regard to HIV infection and methadone treatment outcome

et al. 2017

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Heroin dependent patients have a high incidence of HIV infection. In contrast to the gene expression method, we developed a systemic correlation analysis method built upon the results of pharmacogenomics study in a methadone maintenance treatment (MMT) cohort consisting of 344 Taiwanese heroin dependent patients. We identified genetic variants and their encoding proteins that may be involved with HIV infection and MMT treatment outcome. Cadherin 2 (CDH2) genetic determinants were identified through the genome-wide pharmacogenomic study. We found significant correlations among HIV infection status, plasma levels of CDH2, cytokine IL-7, ADAM10, and the treatment responses to methadone. Two single nucleotide polymorphisms located within CDH2 gene showed associations with blood pressure and plasma CDH2 concentration. Plasma concentration of CDH2 showed correlations with the level of cytokine IL-7, status of HIV infection, and urine morphine test result. Plasma level of IL-7 was correlated with corrected QT interval (QTc) and gooseflesh skin withdrawal symptom score, while level of ADAM10 was correlated with plasma concentrations of vitamin D metabolite, nicotine metabolite, and R-methadone. The results suggest a novel network involving HIV infection and methadone treatment outcome.

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Chemokine IP-10 is correlated with cardiac responses and status of infection with HIV and HCV in methadone maintenance patients

Cited by 3 publications

References 10 publications

Missense mutation at CLDN8 associated with a high plasma interferon gamma-inducible protein 10 level in methadone-maintained patients with urine test positive for morphine

Missense mutation at CLDN8 associated with a high plasma interferon gamma-inducible protein 10 level in methadone-maintained patients with urine test positive for morphine

APBB2 is associated with amphetamine use and plasma beta-amyloids in patients receiving methadone maintenance treatment

Pharmacogenomics study on cadherin 2 network with regard to HIV infection and methadone treatment outcome

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