Chemokine Gene Silencing in Decidual Stromal Cells Limits T Cell Access to the Maternal-Fetal Interface

Nancy, Patrice; Tagliani, Elisa; Tay, Chin Siean; Asp, Patrik; Levy, David E.; Erlebacher, Adrian

doi:10.1126/science.1220030

Cited by 361 publications

(293 citation statements)

References 27 publications

(23 reference statements)

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“…61 Chemokines were also reported as important factors as their epigenetic silencing blocks the access of classical T cells to the fetal-maternal interface. 62 The review by Drs. Perez Leiros and Ramhorst concentrates on the recruitment of immune cells that contribute to tolerance by immune polypeptides that also contribute to tolerance maintenance.…”

Section: Modulators Of the Immune Responses During Pregnancymentioning

confidence: 99%

Adaptive Immune Responses During Pregnancy

Zenclussen

2013

American J Rep Immunol

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It has long been believed that there is no immune interaction between mother and conceptus during pregnancy. This concept changed after evidence was provided that the maternal immune system is aware of the semiallogeneic conceptus and develops strategies to tolerate it. Since then, finely regulated mechanisms of active tolerance toward the fetus have been described. This Special Issue of the American Journal of Reproductive Immunology deals with these mechanisms. It begins with the description of minor histocompatibility antigens in the placenta; it further goes through adaptive immune responses toward paternal fetal antigens, mostly concentrating on regulatory T cells and molecules modulating the Th1/Th2 balance. The participation of antibody‐producing B cells in normal and pathological pregnancies is also discussed. This introductory chapter resumes the concepts presented throughout the Issue and discusses the clinical applications raised from these concepts.

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Section: Modulators Of the Immune Responses During Pregnancymentioning

confidence: 99%

Adaptive Immune Responses During Pregnancy

Zenclussen

2013

American J Rep Immunol

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“…2 DSCs are also important for the development of feto-maternal tolerance. 3,4 Stromal cells have immunosuppressive capacity, [5][6][7] which paved the way for using them in the treatment of inflammatory diseases. Owing to their low immunostimulatory effect, allogeneic third-party stromal cells are often used.…”

Section: Introductionmentioning

confidence: 99%

Stromal cells–are they really useful for GVHD?

Kaipe

Erkers

Sadeghi

et al. 2014

Bone Marrow Transplant

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Mesenchymal stromal cells (MSCs) have immunomodulatory effects and are increasingly being used for the treatment of acute and chronic GVHD. Although they seem immuno-privileged, they induce alloresponses, but the risk of immunization is poorly characterized. After infusion, they first reach the lungs, liver and spleen, and are then difficult to trace. Several mechanisms are involved in stromal cells suppressing alloreactivity, such as induction of regulatory T cells, but whether or not this will also affect leukemic relapse or increase infections is not known. Although several encouraging pilot studies have been published, there have been few prospective randomized trials. There may be a bias in the literature, as negative results are seldom published, and there have been few comparative studies with other immunosuppressive regimens. Most animal models have failed to show any effect on GVHD. Several questions remain to be answered for optimization of stromal cell therapy. Which source is optimal-BM, fat, cord or decidua? Can stromal cells be replaced by exosomes, which culture conditions are most appropriate and at what passage and how frequently should cells be administered? More research is required to move stromal cell therapy forward to become an established treatment for acute and chronic GVHD.

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“…Studies over the past few decades have suggested the presence of progenitor stem cells in the uterus that differentiate during early pregnancy 20 and/or that immune cells are recruited from the peripheral blood by conceptus-dependent or -independent signals. [21][22][23][24] The underlying mechanisms associated with placental development and functions are complex and comprise of intricate regulatory pathways. 25,26 Previous studies have documented the role of many protein-coding genes in the context of pregnancy, reviewed in.…”

Section: Introductionmentioning

confidence: 99%

MicroRNAs, immune cells and pregnancy

et al. 2014

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MicroRNAs (miRNAs) are a recently discovered class of non-coding RNAs that are expressed in many cell types, where they regulate the expression of complementary RNAs, thus modulating the stability and translation of mRNAs. miRNAs are predicted to regulate the expression of ,50% of all protein coding genes in mammals. Therefore, they participate in virtually all cellular processes investigated so far. Altered miRNAs expressions are associated with both physiological (pregnancy) and pathological processes (cancer). As the dynamic maternal-fetal interface plays a critical role in the maintenance of successful pregnancy, it is not surprising that the miRNAs that are unique to reproductive tissues are abundantly expressed. Research in this field has demonstrated the presence and dysregulation of a distinct set of pregnancy-associated miRNAs; however, most studies have centered on localizing various miRNAs in reproductive microdomains associated with normal or complicated pregnancies. Although several independent miRNA regulatory mechanisms associated with endometrial receptivity, immune cells, angiogenesis and placental development have been studied, miRNA-mediated regulation of pregnancy remains poorly understood. This review provides a summary of the current data on miRNA regulation as well as functional profiles of miRNAs that are found in the uterus, in immune cells associated with maternal tolerance to the fetus, and those involved in angiogenesis and placental development.

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Chemokine Gene Silencing in Decidual Stromal Cells Limits T Cell Access to the Maternal-Fetal Interface

Cited by 361 publications

References 27 publications

Adaptive Immune Responses During Pregnancy

Adaptive Immune Responses During Pregnancy

Stromal cells–are they really useful for GVHD?

MicroRNAs, immune cells and pregnancy

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