Chemokine CX3CL1 (Fractalkine) Signaling and Diabetic Encephalopathy
Mateusz Wątroba,
Anna D. Grabowska,
Dariusz Szukiewicz
Abstract:Diabetes mellitus (DM) is the most common metabolic disease in humans, and its prevalence is increasing worldwide in parallel with the obesity pandemic. A lack of insulin or insulin resistance, and consequently hyperglycemia, leads to many systemic disorders, among which diabetic encephalopathy (DE) is a long-term complication of the central nervous system (CNS), characterized by cognitive impairment and motor dysfunctions. The role of oxidative stress and neuroinflammation in the pathomechanism of DE has been… Show more
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