Chemokine (C-C motif) ligand 2 and coronary artery disease: Tissue expression of functional and atypical receptors

Hernández-Aguilera, Anna; Fibla, Montserrat; Cabré, Noemí; Luciano-Mateo, Fedra; Camps, Jordi; Fernández-Arroyo, Salvador; Martín‐Paredero, Vicente; Menendez, Javier A.; Sirvent, Juan J.; Joven, Jorge

doi:10.1016/j.cyto.2019.154923

Cited by 14 publications

(13 citation statements)

References 55 publications

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“…Not only eotaxin, but also MCP‐1 expression is upregulated in atherosclerotic plaques 28,29 . MCP‐1 has been found in atherosclerotic coronary arteries 30 and has been suggested to have a non‐cholesterol‐mediated effect on atherogenesis 31 . Interestingly, a recent Mendelian randomization study showed an association between a genetic predisposition to elevated circulating levels of MCP‐1 and increased risk of ischemic stroke, in particular with LAA stroke and cardioembolic stroke, and with CHD and myocardial infarction 32 .…”

Section: Discussionmentioning

confidence: 99%

Proinflammatory protein signatures in cryptogenic and large artery atherosclerosis stroke

et al. 2020

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Objectives The cause of ischemic stroke remains unknown, cryptogenic, in 25% of young and middle‐aged patients. We hypothesized that if atherosclerosis is prominent in cryptogenic stroke, it would have a similar proinflammatory protein signature as large artery atherosclerosis (LAA) stroke. Materials & Methods Blood was collected in the acute phase and after 3 months from cryptogenic (n = 162) and LAA (n = 73) stroke patients aged 18–69 years and once from age‐matched controls (n = 235). Cryptogenic stroke was divided into Framingham Risk Score (FRS) quartiles to compare low and high risk of atherosclerosis. Plasma concentrations of 25 proteins were analyzed using a Luminex multiplex assay. The discriminating properties were assessed with discriminant analysis and C‐statistics. Results We identified proteins that separated cryptogenic and LAA stroke from controls (area under the curves, AUCs ≥ 0.85). For both subtypes, RANTES, IL‐4, and IFN‐γ contributed the most at both time points. These associations were independent of risk factors of atherosclerosis. We also identified proteins that separated cryptogenic strokes in the lowest quartile of FRS from those in the highest, and from LAA stroke (AUCs ≥ 0.76), and here eotaxin and MCP‐1 contributed the most. Conclusions The protein signature separating cases from controls was different from the signature separating cryptogenic stroke with low risk of atherosclerosis from those with high risk and from LAA stroke. This suggests that increased RANTES, IL‐4, and IFN‐γ in stroke may not be primarily related to atherosclerosis, whereas increased eotaxin and MCP‐1 in cryptogenic stroke may be markers of occult atherosclerosis as the underlying cause.

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Section: Discussionmentioning

confidence: 99%

Proinflammatory protein signatures in cryptogenic and large artery atherosclerosis stroke

et al. 2020

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“…7 Subsequently, sequestered LDL-cholesterol is modified to oxidized LDL-cholesterol and taken up by the monocytes that turn into foam cells. 10 Apart from lipid accumulation, there are numerous inflammatory cells and molecules involved in the atherosclerotic process, such as macrophages, monocytes, adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), E-selectin and P-selectin, Nod-like receptor protein 3 (NLRP3) inflammasome, cytokines, and CRP. 11 In a large meta-analysis including patients without known cardiovascular disease, interleukin (IL)-18, IL-6, tumor necrosis factor (TNF)-a, soluble CD40 ligand, and matrix metalloproteinase-9 were significantly associated with CAD incidence.…”

Section: Myocardial Infarction: Beyond Thrombosismentioning

confidence: 99%

“…15 Moreover, a recent autopsy study concluded that CCL2 levels were significantly increased in both coronary arteries and perivascular tissue of patients with CAD. 10 NLRP3 inflammasome is a complex of intracellular proteins that is activated by a wide variety of stimuli. In atherosclerosis, this complex appears to be activated by cholesterol crystals, hypoxia, and turbulent flow.…”

Section: Myocardial Infarction: Beyond Thrombosismentioning

confidence: 99%

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Colchicine Use in Acute Coronary Syndromes: An Update

Țăpoi¹,

Benchea²,

Siriopol

et al. 2021

Angiology

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Coronary artery disease is the leading cause of death worldwide, and its main pathological substrate is represented by atherosclerosis. Inflammation is a major promoter of the atherosclerotic process and is involved in both the initiation and progression of atherosclerosis, as well as in the occurrence of fatal complications. Until the present moment, Colchicine Cardiovascular Outcomes Trial is the largest trial to demonstrate a major benefit of low-dose colchicine on major adverse cardiac events in patients with recent myocardial infarction (MI), but the mechanisms behind this relation are not completely known. The purpose of this review is to emphasize the possible pathways through which colchicine improves the clinical outcomes in the acute setting of acute coronary syndromes by referring to the results of the studies published in the past 5 years. Aside from its stated systemic anti-inflammatory effect, colchicine could be a valuable addition to the therapeutic approach of acute MI by reducing the infarct size, stabilizing the coronary plaque, as well as reducing platelet aggregation. Moreover, colchicine may improve endothelial function, reduce the transcoronary release of cytokines, and prevent a rise in inflammatory markers after percutaneous coronary intervention, thus diminishing the residual inflammatory risk.

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“…Many researches revealed the association of type 2 diabetes and acutephase proteins or proinflammatory cytokines, much less is known about the probable role of chemokines in the development of type II diabetes [12]. Chemokines are a superfamily of secreted lowmolecular weight proteins with decisive roles in pathophysiological and physiological processes such as angiogenesis, hematopoiesis, atherosclerosis, inflammation and infectious, autoimmune or allergic diseases [13] . Previous studies lack the data on the role of chemokines in type II diabetes among Egyptian Journal of Chemistry http://ejchem.journals.ekb.eg/ ________________________________________________ Egypt.…”

Section: Introductionmentioning

confidence: 99%

RANTES as a novel biomarker for atherogenic dyslipidemia and metabolic disturbances in patients with Type 2 Diabetes

et al. 2021

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RANTES (Regulated upon Activation, Normal T cell Expressed and presumably Secreted) is a chemokine engaged in the pathophysiology of diabetes type 2 (T2DM), related cardiovascular complications, dyslipidemia and hypertension that are major modifiable risk factors of T2DM. VEGF (Vascular endothelial growth factor) plays a role in diabetic vascular complications. Atherogenic dyslipidemia (AD) is a lipid aberration defined as the incidence of raised triglycerides (TG) and dimished high-density lipoprotein cholesterol (HDL-C) and associated with residual cardiovascular risk. However, the association between chemokine and type 2 diabetes (T2DM) and metabolic disturbances is still unclear, and few data are available. The aim of this study was to estimate serum RANTES, serum lipid composition, VEGF, and metabolic syndrome (MS) in patients with T2DM and elucidate their relationship in a sample of Egyptian premenopausal women. Serum level of RANTES, VEGF, lipids and body composition were assessed in 100 premenopausal women with T2DM (mean age 35 years old) and 100 healthy controls. Significant increase in serum RANTES level and VEGF was observed in T2DM compared to the control group. Positive correlations between elevated RANETS and increased values of VEGF, body mass index (BMI), waist circumference (WC), fat mass, LDL-C, TG, total cholesterol and presence of MS were observed in T2DM patients. Elevated RANTES concentration is associated with AD risk, abnormal metabolic components and VEGF levels. This study pinpoints the importance of RANTES as a novel biomarker for dyslipidemia and metabolic disturbance in T2DM patients.

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Chemokine (C-C motif) ligand 2 and coronary artery disease: Tissue expression of functional and atypical receptors

Cited by 14 publications

References 55 publications

Proinflammatory protein signatures in cryptogenic and large artery atherosclerosis stroke

Proinflammatory protein signatures in cryptogenic and large artery atherosclerosis stroke

Colchicine Use in Acute Coronary Syndromes: An Update

RANTES as a novel biomarker for atherogenic dyslipidemia and metabolic disturbances in patients with Type 2 Diabetes

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