Chemokine alterations in bipolar disorder: A systematic review and meta-analysis

Misiak, Błażej; Bartoli, Francesco; Carrà, Giuseppe; Małecka, Monika; Samochowiec, Jerzy; Jarosz, Konrad; Banik, Anna; Stańczykiewicz, Bartłomiej

doi:10.1016/j.bbi.2020.04.013

Cited by 64 publications

(25 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To date, various biological alterations associated with the coronavirus infection have been identified, and some of them, especially those related to the activation of microglia ( Li et al, 2004 ) and cytokine signaling ( Qing et al, 2020 ), might be of relevance to specific mental health outcomes. More and more often, cytokine alterations are being recognized as common findings in mood and psychotic disorders ( Misiak et al, 2020 ; Frydecka et al, 2018 ; Misiak et al, 2019 ); however, causal associations are poorly established and their perception as downstream effectors of the underlying pathology cannot be ruled out. Similarly, microglia activation has also been demonstrated in severe mental disorders ( Enache et al, 2019 ).…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

The SARS-CoV-2 and mental health: From biological mechanisms to social consequences

Szczęśniak

Gładka

Misiak

et al. 2021

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Self Cite

113

View full text Add to dashboard Cite

In December 2019, the first case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) infection was reported. In only few weeks it has caused a global pandemic, with mortality reaching 3.4%, mostly due to a severe pneumonia. However, the impact of SARS-CoV-2 virus on the central nervous system (CNS) and mental health outcomes remains unclear. Previous studies have demonstrated the presence of other types of coronaviruses in the brain, especially in the brainstem. There is evidence that the novel coronavirus can penetrate CNS through the olfactory or circulatory route as well as it can have an indirect impact on the brain by causing cytokine storm. There are also first reports of neurological signs in patients infected by the SARS-Cov-2. They show that COVID-19 patients have neurologic manifestations like acute cerebrovascular disease, conscious disturbance, taste and olfactory disturbances. In addition, there are studies showing that certain psychopathological symptoms might appear in infected patients, including those related to mood and psychotic disorders as well as post-traumatic stress disorder. Accumulating evidence also indicates that the pandemic might have a great impact on mental health from the global perspective, with medical workers being particularly vulnerable. In this article, we provide a review of studies investigating the impact of the SARS-CoV-2 on the CNS and mental health outcomes. We describe neurobiology of the virus, highlighting the relevance to mental disorders. Furthermore, this article summarizes the impact of the SARS-CoV-2 from the public health perspective. Finally, we present a critical appraisal of evidence and indicate future directions for studies in this field.

show abstract

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

The SARS-CoV-2 and mental health: From biological mechanisms to social consequences

Szczęśniak

Gładka

Misiak

et al. 2021

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Self Cite

113

View full text Add to dashboard Cite

show abstract

“…A recent meta-analysis evidenced significantly higher levels of chemokines (i.e., a subgroup of cytokines that can induce directed chemotaxis to the sites of inflammation or injuries) in BD patients than controls [ 11 ]. Interestingly, the increased levels of chemokines also persisted during the euthymic phase, suggesting that these inflammatory mediators could represent longstanding markers of the disorder [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte and Monocyte-to-Lymphocyte Ratio in Bipolar Disorder

et al. 2021

View full text Add to dashboard Cite

Background: Several inflammatory hypotheses have been suggested to explain the etiopathogenesis of bipolar disorder (BD) and its different phases. Neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), and monocyte-to-lymphocyte (MLR) ratios have been proposed as potential peripheral biomarkers of mood episodes. Methods: We recruited 294 patients affected by BD, of which 143 were experiencing a (hypo)manic episode and 151 were in a depressive phase. A blood sample was drawn to perform a complete blood count. NLR, PLR, and MLR were subsequently calculated. A t-test was performed to evaluate differences in blood cell counts between depressed and (hypo)manic patients and a regression model was then computed. Results: Mean values of neutrophils, platelets, mean platelet volume, NLR, PLR, and MLR were significantly higher in (hypo)manic than depressed individuals. Logistic regression showed that PLR may represent an independent predictor of (hypo)mania. Conclusions: Altered inflammatory indexes, particularly PLR, may explain the onset and recurrence of (hypo)manic episodes in patients with BD. As inflammatory ratios represent economical and accessible markers of inflammation, further studies should be implemented to better elucidate their role as peripheral biomarkers of BD mood episodes.

show abstract

“…The association of low levels of eotaxin and PDGF with physiological and cognitive features of ME/CFS is difficult to interpret. Evidence indicates that increased levels of eotaxin-1 and IP-10 are associated with euthymia (100). Platelet-derived growth-factor (PDGF) has been shown to promote blood vessel growth and neuronal survival (101, 102).…”

Section: Discussionmentioning

confidence: 99%

Discriminatory cytokine profiles predict muscle function, fatigue and cognitive function in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

Gusnanto

Earl

Sakellariou

et al. 2020

Preprint

View full text Add to dashboard Cite

Myalgic Encephalomyelitis (ME) /Chronic Fatigue Syndrome (CFS) is a severely debilitating and complex illness of uncertain aetiology, affecting the lives of millions and characterised by prolonged fatigue. The initiating factors and mechanisms leading to chronic debilitating muscle fatigue in ME/CFS are unknown and are complicated by the time required for diagnosis. Both mitochondrial dysfunction and inflammation have been proposed to be central to the pathogenesis of ME/CFS. This original and extensive study demonstrated that although there was little dysfunction evident in the muscle mitochondria of patients with ME/CFS, particular blood plasma and skeletal muscle cytokines, when adjusted for age, gender and cytokine interactions could predict both diagnosis and a number of measures common to patients with ME/CFS. These included MVC and perceived fatigue as well as cognitive indices such as pattern and verbal reaction times. We employed advanced multivariate analyses to cytokine profiles that leverages covariation and intrinsic redundancy to identify patterns of immune signaling that can be evaluated for their predictions of disease phenotype. The current study identified discriminatory cytokine profiles that can be sufficiently used to distinguish HCs from patients with ME/CFS and provides compelling evidence that a limited number of cytokines are associated with diagnosis and fatigue. Moreover, this study demonstrates significant potential of using multiplex cytokine profiles and bioinformatics as diagnostic tools for ME/CFS, potentiating the possibility of not only diagnosis, but also being able to individually personalise therapies.

show abstract

Chemokine alterations in bipolar disorder: A systematic review and meta-analysis

Cited by 64 publications

References 54 publications

The SARS-CoV-2 and mental health: From biological mechanisms to social consequences

The SARS-CoV-2 and mental health: From biological mechanisms to social consequences

Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte and Monocyte-to-Lymphocyte Ratio in Bipolar Disorder

Discriminatory cytokine profiles predict muscle function, fatigue and cognitive function in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

Contact Info

Product

Resources

About