Chemoimmunotherapy for Disseminated Malignant Melanoma With Dtic, Acnu, VCR and Ok432

Chiba, M; Jimbow, Kowichi; Kizukuri, Kei; Homma, Kouichi

doi:10.1111/j.1346-8138.1982.tb02599.x

Cited by 10 publications

(2 citation statements)

References 4 publications

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“…16) Chemoimmunotherapy using dacarbazine and vincristine with OK432 was effective in the treatment of metastatic malignant melanoma of the brain. 4) Therefore, we administered dacarbazine, the most common chemotherapeutic agent currently used for melanoma, in combination with cisplatin, vindesine, and interferon-b every other month according to the treatment regimen for advanced malignant melanoma. 18,24) Eleven courses of this chemoimmunotherapy were administered.…”

Section: Discussionmentioning

confidence: 99%

Neurocutaneous Melanosis Associated With Malignant Leptomeningeal Melanoma in an Adult: Clinical Significance of 5-S-Cysteinyldopa in the Cerebrospinal Fluid -Case Report-

Shinno

Saijo

Uno

et al. 2003

Neurol. Med. Chir.(Tokyo)

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A 35-year-old male presented with a variant of neurocutaneous melanosis with leptomeningeal malignant melanoma. He had three pigmented nevi from birth. He suffered diplopia followed by headache. T1-weighted magnetic resonance (MR) imaging revealed hydrocephalus and a small linear hyperintense lesion in the right frontal cortex. Several parts of the cortical sulci and the brain surface were slightly enhanced by gadolinium. Ventriculoperitoneal shunting was performed and extensive pigmented leptomeninges were recognized. Open biopsy established the diagnosis of leptomeningeal malignant melanoma. Combined chemoimmunotherapy was repeated every other month with monitoring of the 5-S-cysteinyldopa (5-S-CD) level in the cerebrospinal fluid (CSF). The 5-S-CD level decreased after each treatment, but the basal level steadily increased prior to the next treatment. Two years after the onset, he showed paraplegia caused by an extramedullary mass at the T-6 level. MR imaging showed that melanoma had involved the entire subarachnoid space including the whole spine. He underwent emergent removal of the spinal tumor and showed transient marked improvement. Further intensive chemotherapy was given. However, he died 31 months after the onset of massive proliferation of intracranial leptomeningeal melanoma. Measurement of CSF 5-S-CD levels is valuable for evaluating the therapeutic efficacy and for monitoring the progression of melanoma.

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Section: Discussionmentioning

confidence: 99%

Neurocutaneous Melanosis Associated With Malignant Leptomeningeal Melanoma in an Adult: Clinical Significance of 5-S-Cysteinyldopa in the Cerebrospinal Fluid -Case Report-

Shinno

Saijo

Uno

et al. 2003

Neurol. Med. Chir.(Tokyo)

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“…Chiba et al used this agent in combination with cytostatics in metastasizing melanoma. In a treatment of 15 patients, two achieved a complete and one a partial regres sion [20]. In an adjuvant setting, Hayasaka combined this substance with DTIC (Dacarbacin) and compared it to a group treated only with DTIC.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Advanced Malignant Melanoma by a Pyrogenic Bacterial Lysate. A Pilot Study

Kölmel

Vehmeyer

Göhring³

et al. 1991

Oncol Res Treat

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Fifteen patients (8 female, 7 male) with advanced melanoma received intravenous injections of a pyrogenic bacterial lysate consisting of streptococci and serratia marcescens. In three cases with skin metas-tases, this kind of treatment resulted in a total and long lasting remission. In another case with inguinal lymphnode metastases, a five month period of stability was achieved. The remaining eleven patients showed further progression of their disease. Side-effects of therapy included fever, nausea, headache, back pain, and – occasionally – herpes labialis. Laboratory analysis revealed a marked increase in the blood counts of monocytes 24 and 48 hours after injection of the bacterial lysate, while other hemopoietic cells did not show significant alterations. During peak temperatures four to six hours after injection, TNF-alpha serum levels were elevated correlating with the increase in body temperature. The increase in concentration of complexes of thrombin-antithrombin III, prothrombin fragments and soluble fibrin during peak temperatures indicate an activation of the coagulation system without evidence, however, of consumption coagulopathy.

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Immunotherapy

Dabski¹,

Helm²

1988

Skin Cancer

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Chemoimmunotherapy for Disseminated Malignant Melanoma With Dtic, Acnu, VCR and Ok432

Cited by 10 publications

References 4 publications

Neurocutaneous Melanosis Associated With Malignant Leptomeningeal Melanoma in an Adult: Clinical Significance of 5-S-Cysteinyldopa in the Cerebrospinal Fluid -Case Report-

Neurocutaneous Melanosis Associated With Malignant Leptomeningeal Melanoma in an Adult: Clinical Significance of 5-S-Cysteinyldopa in the Cerebrospinal Fluid -Case Report-

Treatment of Advanced Malignant Melanoma by a Pyrogenic Bacterial Lysate. A Pilot Study

Immunotherapy

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