Chemogenomics for drug discovery: clinical molecules from open access chemical probes

Abstract

In recent years chemical probes have proved valuable tools for the validation of disease-modifying targets, facilitating investigation of target function, safety, and translation. Whilst probes and drugs often differ in...

Advances in the Exploration of the Epigenetic Relevant Chemical Space

“…1 Epigenetic target inhibitors are attractive not only for drug development but also as chemical tools to understand the underlying mechanisms of epigenetic regulation. 2 Currently, there are 10 Food and Drug Administration (FDA)-approved drugs related to epigenetic targets, and there are several others under clinical development. 3 Likewise, there are several chemical probes focused on epigenetic targets.…”

“…Several conditions are currently associated with the misregulation of epigenetic targets, such as depressive disorders, multiple sclerosis, diabetes, or Alzheimer’s disease . Epigenetic target inhibitors are attractive not only for drug development but also as chemical tools to understand the underlying mechanisms of epigenetic regulation . Currently, there are 10 Food and Drug Administration (FDA)-approved drugs related to epigenetic targets, and there are several others under clinical development .…”

Target 2035 – update on the quest for a probe for every protein

“…We recognised the lack of tools to study protein function as the main obstacle to progress in this area. Therefore, we launched Target 2035 as an ambitious open science initiative to discover and make available chemogenomic libraries, [8][9][10][11] chemical probes, and/or functional antibodies for nearly all human proteins by the year 2035. 2,12 Target 2035 provides a strategy for the global research community to work together to create the technologies and research tools required to interrogate the function and therapeutic potential of all human proteins.…”

A review on computer‐aided chemogenomics and drug repositioning for rationalCOVID‐19 drug discovery

“…Chemogenomics is different from the traditional pharmaceutical methods due to linking the widespread software library directly to the methodology of modern genomics. In order to achieve this purpose, chemogenomics, along with a contribution of several chemical disciplines, including synthetic chemistry, combinatorial chemistry, cheminformatics, bioinformatics, and genomics, screen synthetic compound libraries for their impact on biological targets (Bredel & Jacoby, 2004 ; Quinlan & Brennan, 2021 ). The ultimate goal of chemogenomics is the rapid screening as well as the rational development of target‐specific chemical ligands to decrease the cost and enhance the drug discovery period, especially in the case of COVID‐19 drug investigation (Jones & Bunnage, 2017 ).…”