Chemogenetic suppression of macaque V4 neurons produces retinotopically specific deficits in downstream IT neural activity patterns and core object recognition behavior

Kar, Kohitij; Schrimpf, Martin; Schmidt, Kailyn; DiCarlo, James J.

doi:10.1167/jov.21.9.2489

Cited by 2 publications

(1 citation statement)

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“…Our next goals are to add a low cost eye tracking system (as mentioned in Figure 3B), and to release the code-base and material for the electronics that we are using. Our kiosks are fully compatible with behavioral testing of macaques paired with chemogenetic perturbations (currently used in this study: Kar et al, 2021), and wireless electrophysiological recordings. As we further develop those studies and techniques at York University, we shall update the system details through this article (or other similar documents).…”

Section: Discussionmentioning

confidence: 99%

Low-cost, portable, easy-to-use kiosks to facilitate home-cage testing of non-human primates during vision-based behavioral tasks

Giverin¹,

Ramezanpour²,

Kar

2023

Preprint

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Non-human primates, especially rhesus macaques, have played a significant role in our current understanding of the neural computations underlying human vision. Apart from the established homologies in the visual brain areas between these two species, and our extended abilities to probe detailed neural mechanisms in monkeys at multiple scales, one major factor that makes NHPs an extremely appealing animal model of human-vision is their ability to perform human-like visual behavior. Traditionally such behavioral studies have been conducted in the controlled laboratory settings. Such in-lab studies offer the experimenter a tight control over many experimental variables. However, typical constraints related to such experiments include, 1) limited total experimental time, 2) requirement of dedicated human experimenters for the NHPs, 3) requirement of additional lab-space, 4) additional time and training required for chairing and head restraints of monkeys, 5) NHPs often need to undergo invasive surgeries for a head-post implant. To overcome these limitations, many laboratories have now adapted home-cage behavioral training and testing of NHPs. Home-cage behavioral testing enables the administering of many vision-based behavioral tasks simultaneously across multiple monkeys with much reduced human personnel requirements, no NHP head restraint, and provide NHPs access to the experiments without specific time constraints. Here, we provide the details of operating and building a portable, easy-to-use kiosk for conducting home-cage vision-based behavioral tasks in NHPs.

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Section: Discussionmentioning

confidence: 99%

Low-cost, portable, easy-to-use kiosks to facilitate home-cage testing of non-human primates during vision-based behavioral tasks

Giverin¹,

Ramezanpour²,

Kar

2023

Preprint

View full text Add to dashboard Cite

show abstract

Low-cost, portable, easy-to-use kiosks to facilitate home-cage testing of nonhuman primates during vision-based behavioral tasks

Ramezanpour,

Giverin,

Kar

2024

Journal of Neurophysiology

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Non-human primates (NHPs), especially rhesus macaques, have significantly contributed to our understanding of the neural computations underlying human vision. Besides the established homologies in the visual brain areas between these species and our ability to probe detailed neural mechanisms in monkeys at multiple scales, NHPs' ability to perform human-like visual behavior makes them an extremely appealing animal model of human vision. Traditionally, such behavioral studies have been conducted in controlled laboratory settings, offering experimenters tight control over variables like luminance, eye movements, and auditory interference. However, in-lab experiments have several constraints, including limited experimental time, the need for dedicated human experimenters, additional lab space requirements, invasive surgeries for head-post implants, and extra time and training for chairing and head restraints. To overcome these limitations, we propose adopting home-cage behavioral training and testing of NHPs, enabling the administration of many vision-based behavioral tasks simultaneously across multiple monkeys with reduced human personnel requirements, no NHP head restraint, and monkeys' unrestricted access to experiments. In this article, we present a portable, low-cost, easy-to-use kiosk system developed to conduct home-cage vision-based behavioral tasks in NHPs. We provide details of its operation and build to enable more open-source development of this technology. Furthermore, we present validation results using behavioral measurements performed in the lab and in NHP home cages, demonstrating the system's reliability and potential to enhance the efficiency and flexibility of NHP behavioral research.

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Chemogenetic suppression of macaque V4 neurons produces retinotopically specific deficits in downstream IT neural activity patterns and core object recognition behavior

Cited by 2 publications

References 0 publications

Low-cost, portable, easy-to-use kiosks to facilitate home-cage testing of non-human primates during vision-based behavioral tasks

Low-cost, portable, easy-to-use kiosks to facilitate home-cage testing of non-human primates during vision-based behavioral tasks

Low-cost, portable, easy-to-use kiosks to facilitate home-cage testing of nonhuman primates during vision-based behavioral tasks

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