Chemogenetic Inhibition of Dopamine D1-expressing Neurons in the Dorsal Striatum does not alter Methamphetamine Intake in either Male or Female Long Evans Rats

Sex differences in methamphetamine use disorder perused from pre-clinical and clinical studies: Potential therapeutic impacts

“…Using a similar dose of METH (0.08 mg/kg/inf), Ruda-Kucerova et al (2015) reported that male rats exhibited higher METH intake during the last 5 days of SA than females. These findings are consistent with the report from our group showing that male Long-Evans rats showed more escalation of their METH intake during the first 9 days of METH SA ( Daiwile et al, 2019 ; Job et al, 2020 ) and greater METH intake than female rats ( Daiwile et al, 2019 ). Venniro et al (2017) also observed steeper escalation of METH SA in males compared to females.…”