Chemogenetic activation of astrocytic Gi signaling promotes spinogenesis and motor functional recovery after stroke
Chaoran Wu,
Yu Li,
Xinran He
et al.
Abstract:Ischemic stroke is the leading cause of adult disability. The rewiring of surviving neurons is the fundamental process for functional recovery. Accumulating evidence implicates astrocytes in synapses and neural circuits formation, but few studies have further studied how to enhance the effects of astrocytes on synapse and circuits after stroke and its impacts on post‐stroke functional recovery. In this study, we made use of chemogenetics to specifically activate astrocytic Gi signaling in the peri‐infarcted se… Show more
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