Chemoenzymatic Installation of Site-Specific Chemical Groups on DNA Enhances the Catalytic Activity
Ze Zhang,
Wanqing Wei,
Siqi Chen
et al.
Abstract:Functional
DNAs are valuable molecular tools in chemical biology
and analytical chemistry but suffer from low activities due to their
limited chemical functionalities. Here, we present a chemoenzymatic
method for site-specific installation of diverse functional groups
on DNA, and showcase the application of this method to enhance the
catalytic activity of a DNA catalyst. Through chemoenzymatic introduction
of distinct chemical groups, such as hydroxyl, carboxyl, and benzyl,
at specific positions, we achieve si… Show more
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