Chemoembolization with CalliSpheres drug-eluting beads loaded with irinotecan in the treatment of unresectable colorectal cancer liver metastases: preliminary results in 16 cases

Kong, Jian; Li, Yong; Bian, Yin-Jian; Jian-xi, Guo; Zhang, Yanfang

doi:10.21037/tcr.2019.05.14

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…Left 921 [30] 455 [25] 466 [37] 876 [29] 45 [41] 747 [28] 174 [44] 916 [30] 5 [29] Right Large intestine NOS 227 [7] 126 [7] 101 [8] 213 [7] 14 [13] 179 [7] 48 [12] 226 [7] 1 [6] Grade <0.001 <0.001 <0.001 0.5 Grade I 390 [13] 304 [17] 86 [7] 386 [13] 4 [4] 363 [14] 27 [7] 388 [13] 2 [12] Grade II 4 [24] Grade III 506 [16] 311 [17] 195 [15] 488 [16] 18 [17] 456 [17] 50 [13] 502 [16] 4 [24] Grade IV 155 [5] 95 [5] 60 [5] 153 [5] 2 [2] 142 [5] 13 [3] 154 [5] 1 [6] Unknown 785 [25] 449 [25] 336 [26] 731 [25] 54...…”

Section: Multivariate Analysismentioning

confidence: 99%

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Pattern of distant metastases and predictive nomograms in colorectal mucinous adenocarcinoma: a SEER analysis

Lian¹,

Xu²,

Xiang‐dong³

et al. 2021

J Gastrointest Oncol

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Background: We evaluated the metastatic patterns and explored the prognostic value of distant metastasis pattern in patients with metastatic colorectal mucinous adenocarcinoma (MC) using the Surveillance, Epidemiology, and End Results (SEER) database.Methods: Between 2010 and 2015, newly diagnosed colorectal MC patients were selected using the SEER database. Patient prognosis was compared based on the clinicopathological parameters, treatment method, and the site and number of metastatic organs. Cox analyses were used to identify factors associated with overall survival (OS). A nomogram was built to predict the patient's survival. Harrell's concordance index (c-index) and calibration curves were used to analyze the discriminative ability of the prognostic factors.Results: Of 3,088 patients diagnosed with colorectal MC, the liver was the only metastatic organ in 78.4% (997/1,271) of all liver metastasis cases, the lung was the only metastatic organ in 41.0% (164/400) of all lung metastasis cases, bone was the only metastatic organ in 26.6% (29/109) of all bone metastasis cases, and the brain was the only metastatic organ in 23.5% (4/17) of all brain metastasis cases. Compared with the untreated cases, those treated with chemotherapy, surgery, and radiotherapy had better OS (P<0.001).There were marked OS differences (P<0.001) between patients with and without liver and bone metastases.Patients with bone metastasis had the best survival, while those with brain metastasis had the worst survival (P<0.001). Patients with one metastatic site had better prognosis compared to those with two or three (P<0.001). Patients with liver metastasis had the best survival, while those with bone and brain metastasis had the worst survival (P<0.001). Multivariate analysis showed that age <65 years, non-black race, grade I, N0 stage, chemotherapy, radiation, surgery, liver metastasis, and bone metastasis were independent prognostic factors. A nomogram was constructed to predict survival probability. The c-index value was up to 0.745. The calibration plot showed that the nomogram was clinically useful.Conclusions: Metastatic MC (mMC) patients had a characteristic distant metastasis pattern. This study constructed a new and sufficiently accurate prognostic model of mMC based on population-based data.These findings can be utilized to predict prognosis and guide mMC patient management.

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Section: Multivariate Analysismentioning

confidence: 99%

“…Colorectal cancer (CRC) is a leading cause of morbidity and mortality worldwide (1). There is mounting evidence that the incidence of CRC is increasing, and approximately half of CRC patients develop distant metastasis (2). CRC classification is based on histology.…”

Section: Introductionmentioning

confidence: 99%

Pattern of distant metastases and predictive nomograms in colorectal mucinous adenocarcinoma: a SEER analysis

Lian¹,

Xu²,

Xiang‐dong³

et al. 2021

J Gastrointest Oncol

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Embolization in Interventional Oncology: Science, Technology, and Theory

Brown

2023

Interventional Oncology

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Drug-Eluting Bead, Irinotecan (DEBIRI) Therapy for Refractory Colorectal Liver Metastasis: A Systematic Review

Soomro,

Osman,

Haridi

et al. 2023

Cureus

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Colorectal cancer and related mortality present a profound challenge in its management, even in this modern age. Even today, colorectal cancer-related deaths rank third in the world. Despite having multiple lines of chemotherapy, combined with radiotherapy and chemoembolization techniques, after or before surgical resection, the five-year survival rate is approximately 20%. Drug-eluting bead, irinotecan (DEBIRI) is a new technique that involves embolization of the feeding vessels to the tumour and delivering irinotecan for its chemotherapeutic effects. A significant amount of literature compares DEBIRI as an adjunct to various lines of chemotherapy. However, so far, not much data are available on DEBIRI as a singular treatment for those patients who have had multiple chemotherapies and still progressing and are not fit for liver resection. In this systematic review, we aim to highlight and bring together the results of those studies that focused on this specific patient group. A systematic search of the literature involving three large databases (published between January 2017 and July 2022), excluding languages other than English, was conducted to identify articles documenting patients who had disease progression despite chemotherapy and were not fit for surgical resection. The level of evidence and the quality check were assessed by two independent reviewers, and consensus with the senior author resolved disagreements. Out of seven studies that met the final criteria, we found a pooled cohort of 302 patients. The mean age of the patients was 61.2 years, ranging from 40.7 to 84 years. The most commonly used DEBIRI beads were M1 (70-150 um) and M2 (100-300 um), but two studies reported the use of 40 um as well. The total number of DEBIRI treatments performed in our pooled cohort was 904. The majority of the studies reported only G1/G2 toxicities among the patients, with maximal toxicity of G4 in a few selected patients. The median overall survival in our pooled cohort was 19.52 months. The median progression-free survival in our data was 5.76 months. Our systematic review concludes that DEBIRI is undoubtedly a useful treatment modality with an acceptable toxicity profile. This treatment offers a good overall survival benefit for refractory colorectal liver metastasis.

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Chemoembolization with CalliSpheres drug-eluting beads loaded with irinotecan in the treatment of unresectable colorectal cancer liver metastases: preliminary results in 16 cases

Cited by 3 publications

References 24 publications

Pattern of distant metastases and predictive nomograms in colorectal mucinous adenocarcinoma: a SEER analysis

Pattern of distant metastases and predictive nomograms in colorectal mucinous adenocarcinoma: a SEER analysis

Embolization in Interventional Oncology: Science, Technology, and Theory

Drug-Eluting Bead, Irinotecan (DEBIRI) Therapy for Refractory Colorectal Liver Metastasis: A Systematic Review

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