Chemodynamic/photothermal synergistic therapy based on Ce-doped Cu–Al layered double hydroxides

Wang, Zhengdi; Fu, Liyang; Zhu, Yuxiang; Wang, Sa; Shen, Guohong; Liu, Jin; Liang, Ruizheng

doi:10.1039/d0tb02547j

Cited by 49 publications

(38 citation statements)

References 60 publications

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“…In addition, other metal elements have also been exploited for realizing two‐metal‐ion‐based CDT. [ 371–388 ] Yang et al. designed ancient pigment nanosheets (SrCuSi 4 O 10 NSs, abbreviated as SC NSs) and functionalized them with GOx to afford SC@G NSs for the synergistic action of ST, PTT, and CDT ( Figure a).…”

Section: Applications Of Cdt In Anticancer and Antibacterial Therapiesmentioning

confidence: 99%

“…constructed Ce‐doped Cu–Al layered double hydroxide (CAC‐LDH) ultrathin nanosheets through a bottom‐up synthetic method, which were further loaded with ICG to obtain ICG/CAC‐LDH composite. [ 379 ] First, Cu 2+ and Ce 4+ of ICG/CAC‐LDH could be reduced by intracellular GSH to Cu + and Ce 3+ , respectively, leading to the GSH depletion. The produced Cu + and Ce 3+ could further react with local H 2 O 2 to generate •OH through the Fenton‐like reactions.…”

Section: Applications Of Cdt In Anticancer and Antibacterial Therapiesmentioning

confidence: 99%

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Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Jia

Guo

2021

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341

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Chemodynamic therapy (CDT), a novel cancer therapeutic strategy defined as the treatment using Fenton or Fenton‐like reaction to produce •OH in the tumor region, was first proposed by Bu, Shi, and co‐workers in 2016. Recently, with the rapid development of Fenton and Fenton‐like nanomaterials, CDT has attracted tremendous attention because of its unique advantages: 1) It is tumor‐selective with low side effects; 2) the CDT process does not depend on external field stimulation; 3) it can modulate the hypoxic and immunosuppressive tumor microenvironment; 4) the treatment cost of CDT is low. In addition to the Fe‐involved CDT strategies, the Fenton‐like reaction‐mediated CDT strategies have also been proposed, which are based on many other metal elements including copper, manganese, cobalt, titanium, vanadium, palladium, silver, molybdenum, ruthenium, tungsten, cerium, and zinc. Moreover, CDT has been combined with other therapies like chemotherapy, radiotherapy, phototherapy, sonodynamic therapy, and immunotherapy for achieving enhanced anticancer effects. Besides, there have also been studies that extend the application of CDT to the antibacterial field. This review introduces the latest advancements in the nanomaterials‐involved CDT from 2018 to the present and proposes the current limitations as well as future research directions in the related field.

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Section: Applications Of Cdt In Anticancer and Antibacterial Therapiesmentioning

confidence: 99%

Section: Applications Of Cdt In Anticancer and Antibacterial Therapiesmentioning

confidence: 99%

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Jia

Guo

2021

Small

341

212

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“…This result was achieved due to the enhanced cell membrane permeability and increased uptake of doxorubicin. Recently, Wang et al described a novel modality combining chemodynamic therapy (CDT) with PTT 124 . The results from in vitro studies showed remarkable CDT/PTT efficacy, with complete apoptosis of the cancer cells.…”

Section: Sonodynamic Therapymentioning

confidence: 99%

Magnetic mediators for ultrasound theranostics

Józefczak¹,

Kaczmarek²,

Bielas³

2021

Theranostics

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“…Further, the coordinating hydroxide groups can be protonated, providing a pH-responsive property which can be utilized in cancer diagnosis and treatment. A number of Gd-doped LDHs have been developed as multifunctional platforms for both bioimaging and treatment [22][23][24]. Other ions have also been explored.…”

Section: Introductionmentioning

confidence: 99%

Gadolinium Doped Layered Double Hydroxides for Simultaneous Drug Delivery and Magnetic Resonance Imaging

et al. 2022

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In this study, gadolinium (Gd) doped MgAl layered double hydroxides (LDHs) were synthesized via a ‘bottom-up’ method and fully characterized by X-ray diffraction, infrared spectroscopy and relaxivity measurements. Two cytotoxic agents were then intercalated via ion-exchange. X-ray diffraction patterns exhibit expanded interlayer spacings as a result of successful drug intercalation. Infrared spectra also showed characteristic peaks of the incorporated methotrexate (MTX) or 5-fluorouracil (5-FU). The LDHs were found to be highly stable under physiological conditions, while in acidic conditions a small proportion of Gd was freed into the immersion medium. Dissolution tests revealed that both 5FU and MTX were rapidly released from the LDH carrier. The longitudinal relaxivity of Gd-LDHs remains largely stable during drug release over 24 h, and was higher in acidic environments. Overall, the drug-loaded Gd-LDH systems prepared in this study could serve as pH-sensitive theranostic platforms for MRI-guided anti-cancer therapy.

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Chemodynamic/photothermal synergistic therapy based on Ce-doped Cu–Al layered double hydroxides

Abstract: The combination of chemodynamic therapy (CDT) with photothermal therapy (PTT) is an efficacious strategy in cancer treatment to acquire satisfactory therapy efficiency under endogenous redox reaction and external laser induction....

Cited by 49 publications

References 60 publications

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Magnetic mediators for ultrasound theranostics

Gadolinium Doped Layered Double Hydroxides for Simultaneous Drug Delivery and Magnetic Resonance Imaging

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