Chemo-profiling and bioassay of phytoextracts from Ageratum conyzoides for acaricidal properties against Rhipicephalus (Boophilus) microplus (Acari: Ixodidae) infesting cattle and buffaloes in India

Kumar, Karapparambu Gopalan Ajith; Tayade, Amol B.; Kumar, Rajesh; Gupta, Suman; Sharma, Anil Kumar; Nagar, Gaurav; Tewari, Shashi Shankar; Kumar, Bhanu; Rawat, Ajay Kumar Singh; Srivastava, Sharad; Kumar, Sachin; Ghosh, Srikant

doi:10.1016/j.ttbdis.2015.12.005

Cited by 28 publications

(17 citation statements)

References 40 publications

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“…aegypti with regard to lethal effects, chemical constituents and components of essential oils of the plant, and to elucidate the morphological changes in adult female mosquitoes following treatment with the plant extract and essential oils. In the literature, there has been considerable variability in the yields of essential oils from varied plant parts, which was consistent with the findings of the present study (Table 1) [22][23][24]. The highest number of chemical components of five out of six types of essential oils of this plant in Thailand (Table 5) was similar to those reported in previous studies, e.g., in Nigeria, hydrodistillation of fresh leaves and flowers yielded 0.25% v/w and 0.06%, with the major component as precocene I (57.2% and 82.2%, respectively) [22,25].…”

Section: Discussionsupporting

confidence: 92%

“…Alternatively, LP extract had precocene II as the predominant compound. Similarly, precocene II (25.89% in South China) was the most abundant in dry leaves and flower parts in South China and dry leaves and stem parts in India, with steam distillation yielding 0.4% (v/w) and 0.1% oil [24,28]. Chemical constituents and major components of essential oils can vary, not only owing to numerous environmental factors such as climates, seasons, soil compositions, plant organs, ages, harvesting times, nutritional status and method of extraction, but also by region [29,30].…”

Section: Discussionmentioning

confidence: 99%

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Insecticidal and Histopathological Effects of Ageratum conyzoides Weed Extracts against Dengue Vector, Aedes aegypti

Pintong

Ampawong

Komalamisra

et al. 2020

Insects

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Crude extracts and essential oils of A. conyzoides were tested with larva and adult stages of Ae. aegypti mosquitoes to determine their insecticidal properties. The crude extracts and essential oils came from three varieties of A. conyzoides (with white flowers, purple flowers, or white-purple flowers) and from two places on each plant (leaves and flowers), giving six types overall: leaf-white (LW); leaf-purple (LP); leaf white-purple (LW-P); flower-white (FW); flower-purple (FP); and flower white-purple (FW-P). Chemical constituents and components of the essential oils were identified using gas chromatography-mass spectrometry (GC-MS). Electron microscopic and histopathological studies were performed to determine the toxicological effects on mosquitoes in terms of morphological alterations. The six types of crude extracts exhibited no activity against individuals in the larval stages. However, six types of essential oils were effective against adult Ae. aegypti females. The mortality of adult Ae. aegypti females was higher from leaf extracts, particularly LP (median lethal dose, LD50 = 0.84%). The number of chemical constituents identified by GC-MS was high in flowers, especially W-P. Precocene I was the most abundant chemical component among the five types of essential oils, except in LP, in which precocene II was the most abundant. Histopathological alterations in adult Ae. aegypti females included compound eye degeneration, muscular damage with cellular infiltration, gut epithelial degeneration and necrosis, pyknotic nuclei in the malpighian epithelium and ovarian cell degeneration. FW and FP plant types exhibited the highest severity of histopathological alterations in mosquitoes compared with other plants, probably owing to the presence of monoterpene compounds in their tissues. The present study demonstrated LP plant extracts from A. conyzoides could be effective adulticides against adult Ae. aegypti. As natural products are biodegradable and exhibit low toxicity to mammalian and non-target organisms, they are suitable candidates for use in vector control programmes.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Insecticidal and Histopathological Effects of Ageratum conyzoides Weed Extracts against Dengue Vector, Aedes aegypti

Pintong

Ampawong

Komalamisra

et al. 2020

Insects

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show abstract

“…Kumar et al () studied the chemical profiling and bioassay of phytoextracts from A . conyzoides for acaricidal properties against Rhipicephalus ( Boophilus ) microplus (Acari: Ixodidae), which infests cattle and buffaloes in India.…”

Section: Pharmacologymentioning

confidence: 99%

“…Kumar et al (2016) studied the chemical profiling and bioassay of phytoextracts from A. conyzoides for acaricidal properties against Rhipicephalus (Boophilus) microplus (Acari: Ixodidae), which infests cattle and buffaloes in India. Various studies have been conducted by different groups to decipher the pharmacology of crude plant extracts…”

mentioning

confidence: 99%

Phytochemical constituents and ethnopharmacological properties of Ageratum conyzoides L.

Yadav

Ganie

Singh

et al. 2019

Phytotherapy Research

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Ageratum conyzoides L. (Asteraceae) is an invasive aromatic herb with immense therapeutic importance. The herb is distributed in tropical and subtropical regions. A. conyzoides has imparted numerous ethnomedicinal uses because it has been used to cure various ailments that include leprosy, skin disorders, sleeping sickness, rheumatism, headaches, dyspnea, toothache, pneumonia and many more. A number of phytoconstituents have been scrutinized such as alkaloids, flavonoids, terpenes, chromenes, and sterols from almost every part of this plant. These phytoconstituents have shown diverse pharmacological properties including antimicrobial, anti‐inflammatory, analgesic, antioxidant, anticancer, antiprotozoal, antidiabetic, spasmolytic, allelopathy, and many more. The plant A. conyzoides has provided a platform for doing pharmaceutical and toxicological research in order to isolate some promising active compounds and authenticate their safety in clinical uses. A. conyzoides provides principal information for advanced studies in the field of pharmaceutical industries and agriculture. Present review article describes the cytogenetics, ethnobotany, phytochemistry, pharmacology, and toxicological aspects of A. conyzoides.

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“…Globally; however, use of synthetic drugs for animal health and production is facing challenges due to a variety of factors, e.g., because of their high costs (Mondal et al, 2013), general toxicity (Patel et al, 2013), drug residual problems in milk and meat (Elmanama and Albayoumi, 2016;Tochi et al, 2016) and development of drug resistance in ticks (Abbas et al, 2014;Coles and Dryden, 2014;Heath and Levot, 2015;Kumar and Partap, 2015;Muyobela et al, 2015;Vudriko et al, 2016) and GIN (Playford et al, 2014;Alonso-Diaz et al, 2008;Borges et al, 2015;Geurden et al, 2015;Muniz-Lagunes et al, 2015;Ramos et al, 2016). In addition, quality of antiparasitic drugs, particularly in developing countries, has led to attention of the stakeholders to find alternatives, may be as a part of drug resistance management programs (Zaman et al, 2012a,b;Sindhu et al, 2014;Ghosh et al, 2015a;Kumar et al, 2016). Prospects of using plants as alternates to synthetic antiparasitic drugs have been discussed in the following paragraphs.…”

Section: Control Of Parasitismmentioning

confidence: 99%

An Overview of Plants with Acaricidal and Anthelmintic Properties

Zaman¹

2017

IJAB

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Geo-climatic and socio-economic conditions provide a favourable environment for parasitic population of livestock in Pakistan. Hard ticks (Ixodidae) and gastrointestinal nematodes pose most serious threats to livestock industry. Stackholders rely on synthetic drugs to control these parasites. Emergence of drug resistance in these parasites; however, has provoked interest in alternate of synthetic drugs. Testing of plants used in ethnoveterinary medicine for their antiparasitic activity employing standard procedures has been reported to be promising. Plants have been most frequently used for deworming purposes followed by as acaricides and insecticides; whereas, reports as to their antiprotozoal use are relatively less. Use of plants as antiparasitics is more frequent in developing countries having low accessability to the modern parasite control practices. Likewise, validation studies on the use of plants as antiparasitics have been more frequently carried out in the developing countries compared with those having livestock farming as commercial enterprise. This article presents an overview of the plants having acaricidal and anthelmintic activity, limitations as to the application of phytotherpay to control parasites and future prospects of the use of plants as antiparasitics.

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Chemo-profiling and bioassay of phytoextracts from Ageratum conyzoides for acaricidal properties against Rhipicephalus (Boophilus) microplus (Acari: Ixodidae) infesting cattle and buffaloes in India

Cited by 28 publications

References 40 publications

Insecticidal and Histopathological Effects of Ageratum conyzoides Weed Extracts against Dengue Vector, Aedes aegypti

Insecticidal and Histopathological Effects of Ageratum conyzoides Weed Extracts against Dengue Vector, Aedes aegypti

Phytochemical constituents and ethnopharmacological properties of Ageratum conyzoides L.

An Overview of Plants with Acaricidal and Anthelmintic Properties

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