Chemo-directed specific targeting of nanoparticle-doxorubicin complexes to tumor in animal model

Sreeja, S.; Nair, Cherupally Krishnan Krishnan

doi:10.1016/j.jddst.2016.01.003

Cited by 7 publications

(4 citation statements)

References 31 publications

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“…204,205 Specific targeting of neoplastic drug doxorubicin to tumors have been achieved by complexing them with nanoparticles of iron-oxide and silver-oxide together with a hypoxic sensitizer Sanazole. 206,207 Targeting of the tumor by external magnetic field is effective in case of peripheral accessible tumors but this method is not suitable for deep seated internal tumors and for these chemotargeting could be effective. Chemotargeting of cytotoxic drugs to tumor could be achieved by utilizing the peculiar properties of tumour microenvironment, particularly the hypoxia in malignant tumors.…”

Section: Combination Therapy and Chemotargetingmentioning

confidence: 99%

“…In tumour bearing mice, oral administration of a complex containing chemotherapeutic doxorubicin (DOX) or the cytotoxic phytoceutical, berberine (BBN) along with iron oxide nanoparticles (NP) and the nitrotriazole compound, sanazole (SAN) result in accumulation of the nanocomplexes (NP-DOX-SAN) and (NP-BBN-SAN) specifically in the tumor site resulting in reduction of tumor volumes in tumor bearing mice. [206][207][208] Thus nanoparticles can be effectively used for chemo-targeting cytotoxic drugs to cancer cells and achieve better therapeutic outcome. However, more studies are needed to initiate clinical trials.…”

Section: Combination Therapy and Chemotargetingmentioning

confidence: 99%

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Strategies for targeted cancer therapy

Krishnan Krishnan Nair,

Sreeja

2024

MOJBM

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Numerous therapeutic measures have been developed in oncology to combat various types of cancer, which is a leading cause of death worldwide. These therapies range from conventional approaches to high-end precision medicines, all aimed at ensuring therapeutic efficacy and the patient's survival. However, drug resistance and off-target side effects continue to hinder treatment efficacy. In the case of solid tumors that have hypoxic regions that cause treatment resistance and a high risk of tumor recurrence. To address this, advanced therapies have been designed or under pipeline to specifically target cancer cells by considering their unique features. This review article primarily focuses on different treatment methods developed using the peculiar properties of the tumor microenvironment.

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Section: Combination Therapy and Chemotargetingmentioning

confidence: 99%

Section: Combination Therapy and Chemotargetingmentioning

confidence: 99%

Strategies for targeted cancer therapy

Krishnan Krishnan Nair,

Sreeja

2024

MOJBM

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“…This quality promotes the efficiency of nanoparticles in tumor therapy [81]. Iron oxide nanoparticle-doxorubicin complexed with hypoxic cell radiosensitizer SAN (sanazole) induced downregulation of HIF-1α [82]. The associated genes, vascular endothelial growth factor (VEGF), and Akt are also downregulated.…”

Section: Hypoxia-inducible Factor-1α (Hif-1α) Pathwaymentioning

confidence: 99%

Mitophagy Induced by Metal Nanoparticles for Cancer Treatment

Mundekkad

Cho

2022

Pharmaceutics

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Research on nanoparticles, especially metal nanoparticles, in cancer therapy is gaining momentum. The versatility and biocompatibility of metal nanoparticles make them ideal for various applications in cancer therapy. They can bring about apoptotic cell death in cancer cells. In addition to apoptosis, nanoparticles mediate a special type of autophagy facilitated through mitochondria called mitophagy. Interestingly, nanoparticles with antioxidant properties are capable of inducing mitophagy by altering the levels of reactive oxygen species and by influencing signaling pathways like PINK/Parkin pathway and P13K/Akt/mTOR pathway. The current review presents various roles of metal nanoparticles in inducing mitophagy in cancer cells. We envision this review sheds some light on the blind spots in the research related to mitophagy induced by nanoparticles for cancer treatment.

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“…The mechanism of sensitization is ascribed to the bioactivation through xanthine oxidase and microsomal NADPH/cytochrome P450 reductase, leading to increased DNA damage 48. Sreeja et al49 composed a nanoparticle formulation containing chemotherapeutic doxorubicin, iron oxide nanoparticles (Fe 3 O 4 NP), together with a hypoxic cell radiosensitizer (SAN) for specific targeting to the tumor sites 50. This complex can specifically target the tumor site, thereby enhancing the efficacy of doxorubicin.…”

Section: Hypoxic-active Nanoparticles As Radiosensitizersmentioning

confidence: 99%

<p>Hypoxia-active nanoparticles used in tumor theranostic</p>

Wang¹,

Shang²,

Niu³

et al. 2019

IJN

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Hypoxia is a hallmark of malignant tumors and often correlates with increasing tumor aggressiveness and poor treatment outcomes. Therefore, early diagnosis and effective killing of hypoxic tumor cells are crucial for successful tumor control. There has been a surge of interdisciplinary research aimed at developing functional molecules and nanomaterials that can be used to noninvasively image and efficiently treat hypoxic tumors. These mainly include hypoxia-active nanoparticles, anti-hypoxia agents, and agents that target biomarkers of tumor hypoxia. Hypoxia-active nanoparticles have been intensively investigated and have demonstrated advanced effects on targeting tumor hypoxia. In this review, we present an overview of the reports published to date on hypoxia-activated prodrugs and their nanoparticle forms used in tumor-targeted therapy. Hypoxia-responsive nanoparticles are inactive during blood circulation and normal physiological conditions but are activated by hypoxia once they extravasate into the hypoxic tumor microenvironment. Their use can enhance the efficiency of tumor chemotherapy, radiotherapy, fluorescence and photoacoustic intensity, and other imaging and therapeutic strategies. By targeting the broad habitats of tumors, rather than tumor-specific receptors, this strategy has the potential to overcome the problem of tumor heterogeneity and could be used to design diagnostic and therapeutic nanoparticles for a broad range of solid tumors.

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Chemo-directed specific targeting of nanoparticle-doxorubicin complexes to tumor in animal model

Cited by 7 publications

References 31 publications

Strategies for targeted cancer therapy

Strategies for targeted cancer therapy

Mitophagy Induced by Metal Nanoparticles for Cancer Treatment

<p>Hypoxia-active nanoparticles used in tumor theranostic</p>

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