Chemistry of α-Oxoesters: A Powerful Tool for the Synthesis of Heterocycles

Transition‐Metal‐Catalyzed Hydrogen‐Transfer Annulations: Access to Heterocyclic Scaffolds

“…Oxygen-and sulfur-containing heterocycles are frequently used in materials and biological chemistry. [37] Cyclic carboxylates are present in large number of natural products and biologically important compounds,a nd it is auseful building block in organic synthesis and polymer synthesis. [38] Over the past decades,t here has been considerable attention focused on the asymmetric synthesis of chiral lactones.T ransitionmetal-catalyzed hydrogen transfer provides access to lactones in an environmentally friendly approach.…”

A Convenient Synthesis of 1,2‐Disubstituted‐cis‐3,4‐Dihydroxypyrrolidines via an Ugi‐Four‐Component‐Reaction/Cycloisomerization/Dihydroxylation Protocol

“…To achieve this goal, we considered the use of ethyl glyoxalate (an α-oxoester) [42] as a key component for the formation of the Ugi adduct. [43] This should increase the acidity of the hydrogen at the position α to the peptide carbonyl group, [44][45][46] and and in turn, this should mean that treatment with a weak base would favor 5-endo-dig cycloisomerization.…”

Pyridylmethylaminoacetic acid functionalized Fe3O4 magnetic nanorods as an efficient catalyst for the synthesis of 2-aminochromene and 2-aminopyran derivatives

“…In continuing our research on nanocatalysts [10,11,40,41] and heterocyclic chemistry [42][43][44] To a preheated mixture of FeCl 3 6H 2 O (4.8 mmol, 1.3 g) and FeCl 2 4H 2 O (2.4 mmol, 0.48 g) in 20 mL of DI water at 40 C, glycine (6.1 mmol, 0.46 g) was added and the pH was adjusted to 11 using ammonia solution, and it was re uxed for 6 h under N 2 ow. By separation of the obtained precipitate using an external magnetic eld and then washing with DI water, and drying in oven at 60 C for 3 h, glycine capped Fe 3 O 4 magnetic nanoparticles were obtained.…”