Chemistry of the Genus Dorstenia

Abegaz, Berhanu M.; Ngadjui, Bonaventure T.; Dongo, Étienne; Bezabih, Merhatibeb

doi:10.2174/1385272003375905

Cited by 42 publications

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“…The plants of the genus Dorstenia are traditionally used in African and South American folk medicine in the treatment of many illnesses such as snakebite, rheumatic, infectious diseases, arthritis ( [Bouquet, 1969], [Adjanohoun et al, 1996], [Abegaz et al, 2000] and [Kuete et al, 2007a]). In Cameroon, the leaves and twigs of Dorstenia barteri Bureau are used as decoction in the treatment of mumps, yaws and infected wounds ([Thomas et al, 1989], [Abegaz et al, 1998] and [Tsopmo et al, 1999]).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of the crude extracts and five flavonoids from the twigs of Dorstenia barteri (Moraceae)

Mbaveng

Ngameni

Kuete

et al. 2008

Journal of Ethnopharmacology

148

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The aim of this study was to evaluate the antimicrobial activity of the crude extract of the twigs of Dorstenia barteri (DBT) as well as that of four of the five flavonoids isolated from this extract. Gram-positive bacteria (six species), Gram-negative bacteria (12 species) and fungi (four species) were used. The agar disc diffusion test was used to determine the sensitivity of the tested samples while the well micro-dilution was used to determine the minimal inhibition concentrations (MIC) and the minimal microbicidal concentration (MMC) of the active samples. The results of the disc diffusion assay openUP (May 2008) showed that DBT, isobavachalcone (1), and kanzonol C (4) prevented the growth of all the 22 tested microbial species. Other compounds showed selective activity. The inhibitory activity of the most active compounds namely compounds 1 and 4 was noted on 86.4% of the tested microorganisms and that of 4-hydroxylonchocarpin (3) Abbreviations

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Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of the crude extracts and five flavonoids from the twigs of Dorstenia barteri (Moraceae)

Mbaveng

Ngameni

Kuete

et al. 2008

Journal of Ethnopharmacology

148

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“…The isolation and characterization of secondary metabolites like coumarins and flavonoids, from a plant prove scientifically that the plant contains antibiotic healing substances is a discipline of phytochemistry (Abegaz et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

In-vitro evaluation of the anti-bacterial properties of crude extracts of Dorstenia mannii (Moraceae)

Fokunang¹,

Mejane²,

Noumie³

et al. 2012

J. Microbiol. Antimicrob.

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Bacterial resistance to classical antibiotics nowadays is becoming a health concern in Cameroon. Patients suffering from bacteria attack spend money to carry out laboratory tests for effective diagnosis, with very little positive results. This is due to the fact that most of our hospitals lack the up to date laboratory equipments, to detect the real antibiotic that will kill a particular bacterium. This has led to more patients spending a lot of money on bacterial infection treatment, and some even end up dying with the disease. It is on this basis that this work was designed to research the antibacterial properties of the extracts namely crude extract, hexane-acetate 25%, hexane-acetate 50%, hexaneacetate 75%, hexane, acetate and methanol of the leaves of Dorstenia mannii, a plant that is readily available from our natural environment at little or no cost. These extracts were tested on the following bacteria species namely; Gram-negative bacteria; Enterobacter aerogenes, Escherichia coli, Klebsiella sp., Proteus mirabilis, Pseudomonas aeruginosa, Salmonella enterica; Gram-positive bacteria; Staphylococcus aureus and Bacillus sp. After some laboratory analysis using the antibiogramme sensitivity test, it was discovered that the extracts of the leaves of D. mannii were only sensitive on three of the eight bacteria used which were, E. coli, S. enterica and Klebsiella sp. The other five namely; P. aeruginosa, E. aerogenes, P. mirabilis, S. aureus and Bacillus sp, were resistant to the extract. The sensitivity level of the three bacteria, that showed positive response where however low. Therefore, more research has to be carried out using different concentrations of the leaves extract for a more conclusive result. This concentration could permit to appreciate the degree of sensitivity and also to see if other bacteria that have not manifested any sensitivity can show some positive response to the extracts. Also, different laboratory methods and more bacteria should be used to prove that the leaves of D. mannii have the potential as a promising antibacterial medicinal plant to either render bacteria inactive or kill them completely.

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“…1 They have shown a variety of biological properties including antibacterial, 2 antifungal, 3 antitumor, 4 antimetastatic, 5 cancer chemopreventive, 6 anti-HIV, 7 anti-vasoconstriction, 8 and antidiabetic activities 9 and have been used in traditional medicines. 10 Interestingly, it was reported that the presence of the geranyl group in chalcone skeleton leads to a remarkable increase in corresponding bioactivities. 11 These important biological activities and properties have aroused interest in the synthesis of naturally occurring geranylated chalcones.…”

Section: Introductionmentioning

confidence: 99%

First Total Synthesis of Prorepensin with a Bis-Geranylated Chalcone

2009

Bulletin of the Korean Chemical Society

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Chemistry of the Genus Dorstenia

Cited by 42 publications

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Antimicrobial activity of the crude extracts and five flavonoids from the twigs of Dorstenia barteri (Moraceae)

Antimicrobial activity of the crude extracts and five flavonoids from the twigs of Dorstenia barteri (Moraceae)

In-vitro evaluation of the anti-bacterial properties of crude extracts of Dorstenia mannii (Moraceae)

First Total Synthesis of Prorepensin with a Bis-Geranylated Chalcone

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