Chemistry of Some Organotin Compounds

Ghani, Hassan; Yousif, Emad

doi:10.22401/anjs.24.3.02

Cited by 6 publications

(6 citation statements)

References 22 publications

(19 reference statements)

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“…It is known that the presence of one or more covalent C-Sn bonds affects the activity of the compound and depends on the number and nature of alkyl substituents (R) associated with the Sn-center. The effect of RnSnX4-n compounds containing various R groups (R = Me, Et, Pr and Bu), as shown by a meta-analysis, depends on the type and number of R groups, and the biological activity decreases in the following series: n-Bu > Ph and Et > Me (Ghani and Yousif 2021). The chemical structure also explains the selectivity of the pharmacological action on various test systems in vitro.…”

Section: Introductionmentioning

confidence: 93%

Evaluation of the pharmacological activity of hybrid organotin compounds in a B16 melanoma model in the classical and metronomic administration modes

Додохова¹,

Сафроненко²,

Котиева³

et al. 2022

RRP

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Introduction: In modern medical chemistry, much attention is paid to the search for new antimetastatic agents based on metal compounds. Organotin compounds promise to be good candidates as the treatment of malignant neoplasms. In order to reduce a possible nonspecific toxic effect of tin compounds and to expand the intended therapeutic use, the paper presents hybrid tin (IV) complexes with Sn-S bond containing a fragment of 2,6-di-tert-butylphenol. The aim of the study was to evaluate the antitumor and antimetastatic effects of bis (3,5-di-tert-butyl-4-hydroxyphenylthiolate) dimethylolol (Me3) and (3,5-di-tert-butyl-4-hydroxyphenylthiolate) triphenylolol (Me5) in a model of transplanted melanoma tumor in B16 mice in classical and metronomic administration mode. Materials and methods: The efficacy of organotin compounds was studied in a model of a transplanted tumor with spontaneous metastasis of C57Bl/6 (female) melanoma B16 mice using the following indicators: average life expectancy, inhibition of tumor growth by weight, tumor mass, and metastasis inhibition index. Results and discussion: The most pronounced antimetastatic effect (54% and 36%) is achieved with a five-fold intraperitoneal injection of Me3 and Me5 at the total doses of 375 mg/kg and 250 mg/kg. The comparable results of the efficacy were obtained in the classical and metronomic modes of the injection of hybrid organotin compounds. With an increase in the injected dose, there is an effect of activating the tumor process with the generalized metastasis. Conclusion: Bis dimethylolol (Me3) and triphenylolol (Me5) compounds demonstrate both a pronounced antimetastatic activity and a multidirectional effect on the growth of the primary focus and the metastasis in lungs, depending on an injected dose.

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Section: Introductionmentioning

confidence: 93%

Evaluation of the pharmacological activity of hybrid organotin compounds in a B16 melanoma model in the classical and metronomic administration modes

Додохова¹,

Сафроненко²,

Котиева³

et al. 2022

RRP

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“…They are usually denoted by the formula RaSnX4-a (a = 1-3, R = aryl or alkyl, X = halogen ion or carboxylate, etc.) (Ghani & Yousif, 2021). (Ghani & Yousif, 2021).…”

Section: Anticancermentioning

confidence: 99%

Synthesis and Biological Activities of Acetaminophen and Ibuprofen Metal Complexes or Derivatives: A Review

Hamdan,

Sukmana,

Nordin

2024

MJS

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We reviewed scientific literature on the synthesis of acetaminophen and ibuprofen, as well as their derivatives and biological properties. The synthesis of acetaminophen involves the acetylation of 4-aminophenol and acetic anhydride, while ibuprofen is synthesised by reacting isobutyl benzene and acetic anhydride in four continuous reaction stages, which are Friedel-Crafts acylation, carbonyl reduction, chloride substitution, and Grignard reaction. To obtain their derivatives, modifications have been made either by complexing the main structure of the drug compound with metal elements or adding certain desired moieties, such as thiourea, amide, ammonium, halogen, silicon, and 1,3,4-oxadiazole. Ibuprofen and acetaminophen have been recognised as effective painkillers and anti-inflammatories. Recently, their derivatives have been implicated in a variety of biological effects. The biological activities of acetaminophen and ibuprofen derivatives have been reported to exhibit urease inhibition and inflammatory inhibition, as well as inhibit the proliferation of breast cancer cells MCF-7. Overall, this review article describes the synthesis of acetaminophen and ibuprofen derivatives, complete with their biological activities such as antimicrobial, antifungal, anti-inflammatory, urease inhibitors, and anticancer.

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“…Numerous industries, including those in the biological sciences, utilize organotin (IV) compounds in various applications [30][31][32][33]. Hence, it can be divided into three major fields of utilization: as thermal stabilizers to prevent degradation of several chlorinated substances, including transformer oils, polyvinyl chloride, chlorinated rubbers, paraffin, and modified plastics; industrial catalysts for a variety of chemical processes, such as the production of polyurethane foam goods and vulcanizing agents for silicone rubbers; and as biocidal properties for utilizing as agricultural fungicides, herbicides, bactericides such as hospital-use disinfectants and other applications [34,35].…”

Section: Applications Of Organotin (Iv) Compoundsmentioning

confidence: 99%

Synthesis and Applications of Organotin(IV) Compounds: Mini Review

Naoom¹,

Yousif²,

Zainulabdeen³

et al. 2023

JSMPM

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Organotin(IV) compounds have seen a marked increase in industry utilization over the years and exhibited enormous economic benefits as well as environmental costs due to their numerous industrial, medical, and agricultural uses and other applications. The present review is a continuation of aseries of reviews on the use of organotin(IV), chemicals, synthesis, characteristics and geometry as well as the industrial and biological applications.

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Chemistry of Some Organotin Compounds

Cited by 6 publications

References 22 publications

Evaluation of the pharmacological activity of hybrid organotin compounds in a B16 melanoma model in the classical and metronomic administration modes

Evaluation of the pharmacological activity of hybrid organotin compounds in a B16 melanoma model in the classical and metronomic administration modes

Synthesis and Biological Activities of Acetaminophen and Ibuprofen Metal Complexes or Derivatives: A Review

Synthesis and Applications of Organotin(IV) Compounds: Mini Review

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