Chemistry of silver(III) and some of its compounds: A review

Ghosh, Rajarshi

doi:10.1016/j.jics.2021.100238

Cited by 4 publications

(8 citation statements)

References 80 publications

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“…95 The 109 Ag NMR spectrum showed two resonances: a singlet at 368.2 ppm and a septet at 2232.6 ppm. The septet exhibits a coupling constant of 40.7 Hz, which is identical with that observed in the 19 F NMR spectrum, indicating that this signal is due to the CF 3 -bound Ag center. Because 109 Ag NMR is sensitive to the oxidation state, 60 these assignments are consistent with known chemical shifts of Ag(III) (δ > 2000).…”

Section: ■ Discussionsupporting

confidence: 70%

“…The silver complex Ag-1 and the 2,3,17,18tetrabromo derivative Ag-1-Br 4 were prepared by treating the free-base corrole 33 with Ag(OAc) in pyridine, following literature procedures. 22 The 1 H and 19 F NMR spectra of both compounds exhibit sharp, well-resolved signals, which indicate that the compounds are diamagnetic. Interestingly, coupling of the β-pyrrole protons to the 107/109 Ag center is observed in the 1 H NMR spectrum (Figure S1).…”

Section: Synthesis and Characterization Of Monomeric Silvermentioning

confidence: 99%

“…The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.inorgchem.2c02285. Summary of the crystallographic data, 1 H and 19 F NMR spectra, other characterization data, and results of DFT calculations (PDF)…”

Section: ■ Associated Contentmentioning

confidence: 99%

“…While argentophilic interactions are pervasive for Ag(I) centers, they have only recently been identified for Ag(III) species. The rarity of Ag(III) complexes has hampered the observation of such interactions. , Double oxidation of a Ag(II) porphyrin dimer with a flexible ethane linker (−CH 2 –CH 2 −) furnishes the Ag(III) dimer (Chart ), which exhibits a short Ag···Ag distance of 3.659 Å in the solid state for the [SbF 6 ] − salt or 3.463 Å for the [PF 6 ] − salt. At 77 K, this complex exhibits an emission feature at 546 nm, suggestive of a metallophilic interaction.…”

Section: Introductionmentioning

confidence: 99%

“…1 H NMR (500 MHz, CDCl 3 , 23 °C): δ 1.03 (t, J = 7.4 Hz, 12H), 1.43 (sextet, J = 7.5 Hz, 8H), 1.60 (m, 8H), 3.08 (m, 8H). 19 The CVs were internally referenced to ferrocene. X-ray photoelectron spectroscopy (XPS) data were recorded using a Thermo Scientific K-Alpha XPS system.…”

Section: ■ Introductionmentioning

confidence: 99%

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Ag(III)···Ag(III) Argentophilic Interaction in a Cofacial Corrole Dyad

et al. 2022

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Metallophilic interactions between closed-shell metal centers are exemplified by d10 ions, with Au(I) aurophilic interactions as the archetype. Such an interaction extends to d8 species, and examples involving Au(III) are prevalent. Conversely, Ag(III) argentophilic interactions are uncommon. Here, we identify argentophilic interactions in silver corroles, which are authentic Ag(III) species. The crystal structure of a monomeric silver corrole is a dimer in the solid state, and the macrocycle exhibits an atypical domed conformation. In order to evaluate whether this represents an authentic metallophilic interaction or a crystal-packing artifact, the analogous cofacial or “pacman” corrole was prepared. The conformation of the monomer was recapitulated in the silver pacman corrole, exhibiting a short 3.67 Å distance between metal centers and a significant compression of the xanthene backbone. Theoretical calculations support the presence of a rare Ag(III)···Ag(III) argentophilic interaction in the pacman complex.

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Section: ■ Discussionsupporting

confidence: 70%

Section: Synthesis and Characterization Of Monomeric Silvermentioning

confidence: 99%

Section: ■ Associated Contentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

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Ag(III)···Ag(III) Argentophilic Interaction in a Cofacial Corrole Dyad

et al. 2022

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Oxidation by Silver(III) Complex: Synthesis, Characterisation and Mechanisms of Un-catalysed and Catalysed Reactions

Bagoji,

Malaganvi,

Gowda

et al. 2024

Chemistry Africa

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Arrest of mouse preterm labor until term delivery by combination therapy with atosiban and mundulone, a natural product with tocolytic efficacy

Siricilla,

Hansen,

Rogers

et al. 2023

Preprint

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There is a lack of FDA-approved tocolytics for the management of preterm labor (PL). In prior drug discovery efforts, we identified mundulone and mundulone acetate (MA) as inhibitors of in vitro intracellular Ca2+-regulated myometrial contractility. In this study, we probed the tocolytic potential of these compounds using human myometrial samples and a mouse model of preterm birth. In a phenotypic assay, mundulone displayed greater efficacy, while MA showed greater potency and uterineselectivity in the inhibition of intracellular-Ca2+. Cell viability assays revealed that MA was significantly less cytotoxic. Organ bath and vessel myography studies showed that only mundulone exerted inhibition of myometrial contractions and that neither compounds affected vasoreactivity of ductus arteriosus. A high-throughput combination screen identified that mundulone exhibits synergism with two clinical-tocolytics (atosiban and nifedipine), and MA displayed synergistic efficacy with nifedipine. Of these combinations, mundulone and atosiban demonstrated a significant improvement in the in vitro therapeutic index compared to mundulone alone. The ex vivo and in vivo synergism of mundulone and atosiban was substantiated, yielding greater tocolytic efficacy and potency on myometrial tissue and reduced preterm birth rates in a mouse model of PL compared to each single agent. Treatment with mundulone after mifepristone administration dose-dependently delayed the timing of delivery. Importantly, the combination of mundulone and atosiban permitted long-term management of PL, allowing 71% dams to deliver viable pups at term (> day 19, 4-5 days post-mifepristone exposure) without visible maternal and fetal consequences. Collectively, these studies provide a strong foundation for the development of mundulone as a single or combination tocolytic for management of PL.

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Chemistry of silver(III) and some of its compounds: A review

Cited by 4 publications

References 80 publications

Ag(III)···Ag(III) Argentophilic Interaction in a Cofacial Corrole Dyad

Ag(III)···Ag(III) Argentophilic Interaction in a Cofacial Corrole Dyad

Oxidation by Silver(III) Complex: Synthesis, Characterisation and Mechanisms of Un-catalysed and Catalysed Reactions

Arrest of mouse preterm labor until term delivery by combination therapy with atosiban and mundulone, a natural product with tocolytic efficacy

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