“…[1] This serendipitous C aminoacylation of amino acids could allow the straightforward synthesis of highly valuable pharmacological scaffolds. Analogous structures to those of the pyrrolidine-2,4-dione derivatives are present in various natural and synthetic compounds, such as ascorbic acid, [2,3] which displays a broad range of well-known biological properties, and tetramic acid, [4] which exhibits antibacterial and antiviral activities. Furthermore, pyrrolidine-2,4-diones serve as significant intermediates in the synthesis of statins, [5][6][7][8][9][10][11] a key structural motif found in peptidomimetic inhibitors of proteases, such as aspartic proteases.…”