Chemistry of Crotononitrile

Elkholy, Yehya M.; Elnagdi, Μ. H.

doi:10.1002/prac.19983400602

Cited by 11 publications

(4 citation statements)

References 124 publications

(7 reference statements)

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“…Furthermore, it has been shown that heterocyclic compounds bearing electron-withdrawing substituents (nitro, acid function, etc.) have shown lower antimicrobial activity against Gram-positive and Gram-negative bacteria than compounds carrying electron-donor substituents such as O-alkyl, O-aryl, and chlorophenyl [16]. In our study, we note that compounds bearing electron-donor substituents on the benzene ring linked to the pyranic nucleus exert a positive antimicrobial activity against some Gram-positive and Gram-negative bacteria such as Staphylococcus aureus, Vibrio parahaemolyticus, and Escherichia coli.…”

Section: Discussionmentioning

confidence: 53%

Synthesis, characterization, and in vitro antimicrobial investigation of novel pyran derivatives based on 8-hydroxyquinoline

Rbaa

Hichar

Bazdi

et al. 2019

Beni-Suef Univ J Basic Appl Sci

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Background: 8-Hydroxyquinoline derivatives are known for their extensive applications in the field of analytical chemistry and separation techniques; their complexes with transition metals also exhibit antibacterial and antifungal activity. Results: In the present study, we synthesized a new series of pyranoquinoline derivatives and evaluated their antibacterial activities. The structures of the synthesized compounds were characterized by Fourier transform infrared (FT-IR), hydrogen-1 nuclear magnetic resonance, carbon-13 nuclear magnetic resonance, and elemental analysis. All the prepared compounds were evaluated in vitro as antimicrobial agents against Gram-positive and Gram-negative bacterial strains (Escherichia coli (ATCC35218), Staphylococcus aureus (ATCC29213), Vibrio parahaemolyticus (ATCC17802), and Pseudomonas aeruginosa (ATCC27853)). The screening test was determined by using the standard protocol of disc diffusion method (DDM). Conclusion: We have synthesized new pyranic compounds bearing an 8-hydroxyquinoline moiety on their structure. The preliminary screening results showed that all the tested compounds have a remarkable inhibitory effect on the growth of the majority of the tested bacterial strains compared to the standard antibiotic (penicillin G), and the chlorinated compound (Q 1) is more active against Gram-positive bacteria than Gram-negative bacteria such as the Staphylococcus aureus strain which is the most sensitive. Gram-positive bacteria are responsible for a wide range of infectious diseases, and rising resistance in this group is causing increasing concern. Thus, this study develops novel heterocyclic compound derivatives of 8-hydroxyquinoline that have demonstrated good antibacterial activity against Gram-positive bacteria.

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Section: Discussionmentioning

confidence: 53%

Synthesis, characterization, and in vitro antimicrobial investigation of novel pyran derivatives based on 8-hydroxyquinoline

Rbaa

Hichar

Bazdi

et al. 2019

Beni-Suef Univ J Basic Appl Sci

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“…Very recently, we reported an efficient synthesis of 2-arylhydrazono-3-oxoalkanonitrile 3 by reacting 2 with hydroxylamine hydrochloride in a domestic microwave oven. 14 Since this synthesis is more general in its scope than the established routes to 3 either from reaction of hydrazonyl halides 4 and cyanide ion 15 or via coupling 3-oxoalkanonitriles 5 with aromatic diazonium salts [16][17][18] (Scheme 1), it seemed of value to investigate further the scope of this synthesis. The investigation was further prompted by an interest in 2 as precursors to 4-arylazo-5-aminopyrazoles that are of potential use in D 2 T 2 printing dyes, and in hair, fur and leather dyes.…”

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confidence: 99%

Chemistry of 2-Arylhydrazonals: Utility of Substituted 2-Arylhydrazono-3-Oxoalkanals as Precursors for 3-Oxoalkanonitriles, 3-Aminoisoxazole and 1,2,3- and 1,2,4-Triazoles

El‐Dusouqui

Abdelkhalik

Al‐Awadi

et al. 2006

Journal of Chemical Research

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“…The usefulness of aliphatic nitriles as solvents as well as intermediates has been known in the preparation of polymers, plastics, fibers, resins, and pharmaceuticals . Of the many aliphatic nitriles that are commonly employed, crotononitrile is versatile owing to its reactivity towards nucleophiles as well as electrophiles . In addition, crotonic acid, which can be prepared by hydrolysis of crotononitrile, is a useful industrial chemical.…”

Section: Introductionmentioning

confidence: 99%

“…[13] Of the many aliphatic nitriles that are commonly employed, crotononitrile is versatile owing to its reactivity towards nucleophilesa sw ella se lectrophiles. [14] In addition, crotonic acid, which can be prepared by hydrolysis of crotononitrile, is au seful industrial chemical. During the course of the present study,w eo bserved that I·DMF(Zn) appearst oa bsorbs cis-crotononitrile selectively over trans-crotononitrile.…”

Section: Introductionmentioning

confidence: 99%

Selective Separation of Aliphatic Nitriles by Employing a Two‐Dimensional Interdigitated Coordination Polymer

Mistry

Hota

Natarajan

2017

Chemistry An Asian Journal

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A room-temperature slow diffusion reaction of the metal nitrates [M=Zn and Co ] with 5-azido isophthalic acid (AIPA) and 1,4-bis(4-pyridyl)-2,3-diaza-1,3-butadiene (BPDB) resulted in a new two-dimensional interdigitated coordination polymer, [M(C H N O )(C H N )]⋅DMF [DMF=dimethyl formamide (C H NO)]. The non-bonded DMF molecules were found to exchange through a single-crystal to single-crystal (SCSC) fashion with many aliphatic nitrile compounds. More importantly, the present compound, I⋅DMF(Zn) appears to absorb cis-crotononitrile selectively from the cis/trans mixture as well as a mixture containing the structural isomer (allylnitrile). It also preferentially absorbs propionitrile from an equimolar mixture of acetonitrile, propionitrile, and butyronitrile (1:2:1). The cobalt compound exhibits anti-ferromagnetic behavior.

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Chemistry of Crotononitrile

Cited by 11 publications

References 124 publications

Synthesis, characterization, and in vitro antimicrobial investigation of novel pyran derivatives based on 8-hydroxyquinoline

Synthesis, characterization, and in vitro antimicrobial investigation of novel pyran derivatives based on 8-hydroxyquinoline

Chemistry of 2-Arylhydrazonals: Utility of Substituted 2-Arylhydrazono-3-Oxoalkanals as Precursors for 3-Oxoalkanonitriles, 3-Aminoisoxazole and 1,2,3- and 1,2,4-Triazoles

Selective Separation of Aliphatic Nitriles by Employing a Two‐Dimensional Interdigitated Coordination Polymer

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