Chemistry of Antimony in Radiopharmaceutical Development: Unlocking the Theranostic Potential of Sb Isotopes
Aivija Grundmane,
Valery Radchenko,
Caterina F. Ramogida
Abstract:Antimony‐119 (119Sb) holds promise for radiopharmaceutical therapy (RPT), emitting short‐range Auger and conversion electrons that can deliver cytotoxic radiation on a cellular level. While it has high promise theoretically, experimental validation is necessary for 119Sb in vivo applications. Current 119Sb production and separation methods face robustness and compatibility challenges in radiopharmaceutical synthesis. Limited progress in chelator development hampers targeted experiments with 119Sb. This review … Show more
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