Chemistry of 3-Oxo-<i>N</i>-(pyridin-2-yl)butanamide and Related Compounds

Fadda, Ahmed A.; Abdel‐Galil, Ebrahim; Elattar, Khaled M.

doi:10.1080/00397911.2015.1048369

Cited by 13 publications

(5 citation statements)

References 60 publications

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“…3‐oxo‐ N ‐(pyridin‐2‐yl)butanamide was synthesized and used as a ligand by Fadda et al. [ 84 ] On this basis, Saad et al. develop an iron(III) complex combines iron metal ion and 3‐oxo‐ N ‐(pyridin‐2‐yl)butanamide ligand that may be effective with less toxicity toward healthy tissues.…”

Section: Traditional Drugs Desiderate Improvements By Nanotechnologymentioning

confidence: 99%

“…activity. 3-oxo-N-(pyridin-2-yl)butanamide was synthesized and used as a ligand by Fadda et al [84] On this basis, Saad et al develop an iron(III) complex combines iron metal ion and 3-oxo-N-(pyridin-2-yl)butanamide ligand that may be effective with less toxicity toward healthy tissues. [85] In the meantime, there are iron(III) complexes with decreased anticancer activities compared with parent/reference compounds.…”

Section: Iron(iii) Complexesmentioning

confidence: 99%

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Ferroptosis: The Entanglement between Traditional Drugs and Nanodrugs in Tumor Therapy

Liu

Huang

et al. 2023

Adv Healthcare Materials

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Ferroptosis is a non‐apoptotic programmed cell death caused by the accumulation of lipid peroxide. System Xc‐/glutathione peroxidase 4 (GPX4) axis and iron axis are two main pathways regulating ferroptosis. Simultaneously, multiple pathways are also involved in the ferroptosis regulation. Ferroptosis is an intense area of the current study. With the improvement of the regulatory mechanisms that underlie ferroptosis, a variety of drugs associated with ferroptosis have been discovered and developed for cancer therapy. Among them, traditional drugs were developed initially. Small molecule compounds that regulate ferroptosis signaling pathway and iron complexes that promote the Fenton reaction have become important drugs for inducing ferroptosis. In recent years, the emerging development of nanotechnology has promoted the research of ferroptosis nanodrugs. Iron‐based nanomaterials are extensively tested as ferroptosis‐inducing agents. Furthermore, nanoscale drug delivery systems offer a suitable scaffold for traditional drug therapies. Traditional drugs and nanodrugs are complementary, each with their own strengths and limitations. This review describes the latest studies on the regulation of ferroptosis in tumor cells and focuses on the entanglement between traditional drugs and nanodrugs. To conclude, the challenges and perspectives in this field are put forward.

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Section: Traditional Drugs Desiderate Improvements By Nanotechnologymentioning

confidence: 99%

Section: Iron(iii) Complexesmentioning

confidence: 99%

Ferroptosis: The Entanglement between Traditional Drugs and Nanodrugs in Tumor Therapy

Liu

Huang

et al. 2023

Adv Healthcare Materials

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“…Woodward and co‐workers [43] used air‐stable AlMe 3 and DABCO adduct (DABAL‐Me 3 , 29 ), to promote the aminolysis of methyl 3‐oxohexanoate to β ‐keto amide 30 in 89 % yield (Scheme 6d). Besides, AgOTf‐catalyzed, [44] microwave‐assisted, [45] and hexafluoroisopropanol‐promoted [46] procedures have also been developed.…”

Section: Synthesis Of β‐Keto Amidesmentioning

confidence: 99%

β‐Keto Amides: A Jack‐of‐All‐Trades Building Block in Organic Chemistry

Zheng

et al. 2021

Eur J Org Chem

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β‐Keto amides are a versatile class of compounds that find wide applications in organic chemistry owing to the juxtaposition of multiple reaction sites within their molecular structures. Due to the importance of β‐keto amides in modern organic chemistry, numerous novel preparation methods, synthetic applications and unprecedented reactivities have been recorded over the past decade. Taking advantage of transition‐metal‐catalysis and organocatalysis, β‐keto amides have emerged into a jack‐of‐all‐trades building block for many stereoselective or tandemized multicomponent reactions. But so far, no reviews have been documented on these recent achievements with β‐keto amides. Our Review aims to provide a thorough summary regarding: (a) the synthesis of β‐keto amides, (b) the reactivities of β‐keto amides, (c) the synthetic applications of β‐keto amides in various important heterocyclic compounds, and (d) the coordination of β‐keto amides with main group elements and transition metals and the relevant applications.

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“…Propelled by our interest in the synthesis of medicinally active heterocyclic molecules, [38][39][40][41][42][43][44][45] and in a continuation of our previous reviews into the chemistry of 1,2,4-and 1,2,5-triazepines, 36,37 herein, we report a deep and schematic study of the chemistry and applications of 1,3,5-triazepine heterocycles.…”

Section: Introduction and Scopementioning

confidence: 99%