Chemistry, natural sources, dietary intake and pharmacokinetic properties of ferulic acid: A review

Zhao, Zhaohui; Moghadasian, Mohammed H.

doi:10.1016/j.foodchem.2008.02.039

Cited by 527 publications

(376 citation statements)

References 97 publications

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“…2), which indicated ferulic acid derivatives synthesized by solid phase synthesis on wang Fig (3). 1 HNMR of F-Tyr.…”

Section: Synthesesmentioning

confidence: 99%

“…Ferulic acid, a hydroxycinnamic acid, is an abundant phenolic phytochemical component, and has many medical functions, such as anti-platelet aggregation, inhibiting the generation of platelet thromboxane A2(TXA2), anti-inflammatory, analgesic and regulating immune system [1,2]. Some studies also suggest that ferulic acid is an antioxidant reacting with free radicals and involving DNA damage, cancer and cell aging [3,4].…”

Section: Introductionmentioning

confidence: 99%

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Solid Phase Syntheses of Ferulic Acid Derivatives Acetyl Feruloyl Tyrosine and Acetyl Feruloyl Valyl Tyrosine

Zhao¹,

Ma²,

Lü³

et al. 2015

TOBIOTJ

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Ferulic acid was used as a common drug for cardia-cerebrovascular disease and leukopenia, but the application of ferulic acid was inhibited by the poor absorption and stability. The improvement of these defects can be realized by modifying ferulic acid by amino acids, because the amido bond can increase the bioavailability and therapeutic effect of some drugs based on the peptide transporter system of mammalian which can transport the peptidyl drugs. The peptidyl derivatives of ferulic acid, namely acetyl feruloyl tyrosine and acetyl feruloyl valyl tyrosine, were synthesized using Fmoc solid-phase synthesis method. The synthesized ferulic acid amide derivatives were purified by RP-HPLC, and characterized by IR, 1 HNMR and ESI-MS. The results indicated that Fmoc solid phase synthesis was a convenient method for the amide bond modification of ferulic acid and the further property research on ferulic acid derivatives.

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“…2), which indicated ferulic acid derivatives synthesized by solid phase synthesis on wang Fig (3). 1 HNMR of F-Tyr.…”

Section: Synthesesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Solid Phase Syntheses of Ferulic Acid Derivatives Acetyl Feruloyl Tyrosine and Acetyl Feruloyl Valyl Tyrosine

Zhao¹,

Ma²,

Lü³

et al. 2015

TOBIOTJ

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show abstract

“…Although in vitro studies can give some information about the antioxidant activity and possible biological effects of rice phenolics, the relevance of this information to antioxidant effectiveness in the organism is very limited without data on their bioavailability and metabolism (Collins, 2005). The bioavailability differs greatly from one polyphenol to another due to several factors, such as food matrix, concentration of the polyphenol in the food, background diet and interindividual variations, affecting the concentration of active metabolites in the organism (Manach et al, 2005;Zhao and Moghadasian, 2008). However, few studies have been developed to evaluate the antioxidant properties of rice phenolics in vivo, and most of them used animal models instead of humans.…”

Section: Antioxidant Activity and Biological Effectmentioning

confidence: 99%

Phenolic compounds and antioxidant activity of rice

Walter

Marchesan

2011

Braz. arch. biol. technol.

128

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“…Corn bran represents one of the best possible source of ferulic acid among agricultural crops, with up to 26 mg/g substrate reported for refined maize bran (Zhao and Moghadasian 2008). In this study, treatment with a crude A. niger D15[AtfaeA] extract released 26.56 mg/g ferulic acid from maize bran to, whereas 8.86 mg/g ferulic acid was released from triticale bran (Table 3).…”

Section: Release Of Phenolic Acids From Maize and Triticale Branmentioning

confidence: 65%

Enrichment of maize and triticale bran with recombinant Aspergillus tubingensis ferulic acid esterase

Zwane

Zyl²,

Duodu

et al. 2017

J Food Sci Technol

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Ferulic acid is a natural antioxidant found in various plants and serves as a precursor for various fine chemicals, including the flavouring agent vanillin. However, expensive extraction methods have limited the commercial application of ferulic acid, in particular for the enrichment of food substrates. A recombinant Aspergillus tubingensis ferulic acid esterase Type A (FAEA) was expressed in Aspergillus niger D15#26 and purified with anion-exchange chromatography (3487 U/mg, K m = 0.43 mM, K cat = 0.48/min on methyl ferulate). The 36-kDa AtFAEA protein showed maximum ferulic acid esterase activity at 50°C and pH 6, suggesting potential application in industrial processes. A crude AtFAEA preparation extracted 26.56 and 8.86 mg/g ferulic acid from maize bran and triticale bran, respectively, and also significantly increased the levels of p-coumaric and caffeic acid from triticale bran. The cost-effective production of AtFAEA could therefore allow for the enrichment of brans generally used as food and fodder, or for the production of fine chemicals (such as ferulic and p-coumaric acid) from plant substrates. The potential for larger-scale production of AtFAEA was demonstrated with the A. niger D15[AtfaeA] strain yielding a higher enzyme activity (185.14 vs.83.48 U/ml) and volumetric productivity (3.86 vs. 1.74 U/ ml/h) in fed-batch than batch fermentation.

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Chemistry, natural sources, dietary intake and pharmacokinetic properties of ferulic acid: A review

Cited by 527 publications

References 97 publications

Solid Phase Syntheses of Ferulic Acid Derivatives Acetyl Feruloyl Tyrosine and Acetyl Feruloyl Valyl Tyrosine

Solid Phase Syntheses of Ferulic Acid Derivatives Acetyl Feruloyl Tyrosine and Acetyl Feruloyl Valyl Tyrosine

Phenolic compounds and antioxidant activity of rice

Enrichment of maize and triticale bran with recombinant Aspergillus tubingensis ferulic acid esterase

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