Chemistry, biological activities and toxic effects of alkaloidal constituents of genus Delphinium - A mini review

Lotfaliani, Mohammadreza; Ayatollahi, Seyed Abdulmajid; Kobarfard, Farzad; Ghanadian, Mustafa; Pour, Pardis Mohammadi

doi:10.34172/jhp.2021.56

Cited by 5 publications

(4 citation statements)

References 86 publications

(116 reference statements)

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“…In this investigation, DPPH radical scavenging, Hydroxyl scavenging effect, reducing power, and superoxide radical anion scavenging have shown the antioxidant potential of D. roylei extracts and were observed to be significant when compared to positive controls such as Ascorbic acid, BHT, Rutin, and BHT respectively. These observations are in accordance with the previous studies on the antioxidant potential of Delphinium malabaricum extracts that the DPPH radical scavenging assay has investigated and the Ferric reducing antioxidant power (FRAP) assay ( Lotfaliani et al, 2021 )…”

Section: Discussionsupporting

confidence: 92%

Network pharmacology combined with molecular docking and in vitro verification reveals the therapeutic potential of Delphinium roylei munz constituents on breast carcinoma

Mir,

Bhat,

Kumar

et al. 2023

Front. Pharmacol.

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Delphinium roylei Munz is an indigenous medicinal plant to India where its activity against cancer has not been previously investigated, and its specific interactions of bioactive compounds with vulnerable breast cancer drug targets remain largely unknown. Therefore, in the current study, we aimed to evaluate the anti-breast cancer activity of different extracts of D. roylei against breast cancer and deciphering the molecular mechanism by Network Pharmacology combined with Molecular Docking and in vitro verification. The experimental plant was extracted with various organic solvents according to their polarity index. Phytocompounds were identified by High resolution-liquid chromatography-mass spectrometry (HR-LC/MS) technique, and SwissADME programme evaluated their physicochemical properties. Next, target(s) associated with the obtained bioactives or breast cancer-related targets were retrieved by public databases, and the Venn diagram selected the overlapping targets. The networks between overlapping targets and bioactive were visualized, constructed, and analyzed by STRING programme and Cytoscape software. Finally, we implemented a molecular docking test (MDT) using AutoDock Vina to explore key target(s) and compound(s). HR-LC/MS detected hundreds of phytocompounds, and few were accepted by Lipinski’s rules after virtual screening and therefore classified as drug-like compounds (DLCs). A total of 464 potential target genes were attained for the nine quantitative phytocompounds and using Gene Cards, OMIM and DisGeNET platforms, 12063 disease targets linked to breast cancer were retrieved. With Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment, a total of 20 signalling pathways were manifested, and a hub signalling pathway (PI3K-Akt signalling pathway), a key target (Akt1), and a key compound (8-Hydroxycoumarin) were selected among the 20 signalling pathways via molecular docking studies. The molecular docking investigation revealed that among the nine phytoconstituents, 8-hydroxycoumarin showed the best binding energy (−9.2 kcal/mol) with the Akt1 breast cancer target. 8-hydroxycoumarin followed all the ADME property prediction using SwissADME, and 100 nanoseconds (ns) MD simulations of 8-hydroxycoumarin complexes with Akt1 were found to be stable. Furthermore, D. roylei extracts also showed significant antioxidant and anticancer activity through in vitro studies. Our findings indicated for the first time that D. roylei extracts could be used in the treatment of BC.

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Section: Discussionsupporting

confidence: 92%

Network pharmacology combined with molecular docking and in vitro verification reveals the therapeutic potential of Delphinium roylei munz constituents on breast carcinoma

Mir,

Bhat,

Kumar

et al. 2023

Front. Pharmacol.

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“…Among them, medicinal herbs, which comprise a quarter of all vascular plants in the flora of Kazakhstan, are a sought-after natural resource [18]. Hence, practical significance lies in the data related to the reserves of raw materials acquired for 18 officially recognized medicinal herbs that possess a variety of therapeutic effects, for Achillea millefolium (stomachic, antihelminthic) [19], Aconitum leucostomum (analgesic, antiarrhythmic) [20], Alhagi pseudalhagi (choleretic, hypolipidemic) [21], Cistanche salsa (antibacterial, for diseases of the reproductive and circulatory systems) [22,23], Delphinium elatum (emetic, diuretic) [24], Filipendula ulmaria (antiulcerogenic, hypoglycemic) [25], species Glycyrrhiza L. (expectorative, detoxification) [26], Hippophae rhamnoides (polyvitaminic) [27], Juniperus pseudosabina (antiseptic) [28], Origanum vulgare (expectorative, sedative) [29], Ziziphora clinopodioides (cardiotonic, general tonic) [30], Patrinia intermedia (sedative, hypotensive) [31], Hypericum perforatum (astringent, anti-inflammatory), Peganum harmala (anticholinesterase, abortive), Rheum tataricum (astringent, antineoplastic), Rumex tianschanicus (P-vitamin, laxative), Veratrum lobelianum (antineoplastic, antibacterial) [32].…”

Section: Resultsmentioning

confidence: 99%

Sustainable use of economically valuable and conservation of rare plant species in Almaty region

Sitpayeva,

Gemejiyeva,

Vesselova

et al. 2024

BIO Web Conf.

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The paper contains the results of the initial cadastral survey and integrated assessment of the components of the flora (plant resources, higher plants and algae) of the Almaty region (2021–2023), which occupies a leading position among the economically developed regions of the country. The reserves of raw materials of 18 plant species demanded by the domestic pharmaceutical industry discovered on the territory of 13 administrative districts are of practical value. Eleven species of medicinal plants can be recommended for industrial harvesting. It is important to note that conservation efforts are required to protect 118 rare species of higher vascular plants and three species of lower plants, such as algae – indicating the vegetation’s current condition in the region. For the first time, the region’s list of rare flora species includes 13 species that have been categorized into IV categories based on the criteria and categories of the Red List of the International Union for Conservation of Nature. The results obtained will serve as a scientific basis for regular monitoring and forecasting of effective environmental activities that ensure the sustainable use and conservation of plant resources in the region.

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“…‘Nirmasi’, or ‘Nirmashi’, one of the commonly used medicinal herbs in Nepal, is a species that belongs to the genus Delphinium of the family Ranunculaceae of which more than 356 species are identified. Nirmasi is infamously used for fever, headache, abdominal pain, jaundice, epilepsy, cough, and skin rashes which may be attributed to its antimicrobial, anti-inflammatory, antineoplastic, antifeedant, and cholinesterase inhibition properties 1 , 2 . As studies have suggested, the substance responsible for the medicinal properties of Delphinium is diterpenoid alkaloids.…”

Section: Introductionmentioning

confidence: 99%

“…As studies have suggested, the substance responsible for the medicinal properties of Delphinium is diterpenoid alkaloids. However, it is a lesser-known fact that the same substances have the potential to cause toxicity with manifestations ranging from gastric irritation to fatal arrhythmias 1 , 3 . We present a novel case of the occurrence of a ventricular storm after ingestion of Delphinium as an herbal treatment for their acidity.…”

Section: Introductionmentioning

confidence: 99%

Ventricular tachycardia storm after accidental poisoning of delphinium species: a rare case report

Shrestha,

Thapa,

Hussain

et al. 2024

Annals of Medicine &Amp; Surgery

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Introduction: Delphinium species are commonly used as medicinal herbs, with a wide range of implications for medical conditions. The injudicious use of this plant has been known to cause devastating side effects, including cardiac arrhythmias. Case Presentation: Here, we present an 80 yr old male with incessant ventricular tachycardia after ingestion of this herb. The sinus rhythm was restored after electrical cardioversion and aggressive intravenous antiarrhythmics. Clinical Discussion: To the best knowledge of the authors, no case of a ventricular storm following ingestion of Delphinium has been reported till now, probably rendering this case the first one. Conclusion: This report aims to present the rare case using theoretical concepts from the discipline and to share our approach in the hope of achieving a better understanding of similar cases.

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Chemistry, biological activities and toxic effects of alkaloidal constituents of genus Delphinium - A mini review

Cited by 5 publications

References 86 publications

Network pharmacology combined with molecular docking and in vitro verification reveals the therapeutic potential of Delphinium roylei munz constituents on breast carcinoma

Network pharmacology combined with molecular docking and in vitro verification reveals the therapeutic potential of Delphinium roylei munz constituents on breast carcinoma

Sustainable use of economically valuable and conservation of rare plant species in Almaty region

Ventricular tachycardia storm after accidental poisoning of delphinium species: a rare case report

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