Chemistry and Toxicology Behind Insecticides and Herbicides

Sousa, Sara; Maia, Maria Luz; Correira-Sá, L.; Fernandes, Virgínia Cruz; Delerue–Matos, Cristina; Calhau, Conceição; Domingues, Valentina F.

doi:10.1007/978-3-030-23396-9_3

Cited by 16 publications

(9 citation statements)

References 152 publications

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“…19 On the other hand, GLU has low acute toxicity or moderate toxicity and is little absorbed in animals and can be quickly eliminated. 20,21 Although there has been recent focus on herbicide residues in tea, as far as we know there is still a lack of large quantities of objective data on the dietary risk of drinking tea.…”

Section: Introductionmentioning

confidence: 99%

“…Studies have pointed out that glyphosate is toxic to the liver, immune system, and reproductive system, among other ill effects. , There still remain controversies over its carcinogenicity . On the other hand, GLU has low acute toxicity or moderate toxicity and is little absorbed in animals and can be quickly eliminated. , Although there has been recent focus on herbicide residues in tea, as far as we know there is still a lack of large quantities of objective data on the dietary risk of drinking tea.…”

Section: Introductionmentioning

confidence: 99%

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Establishment of a HPLC–MS/MS Detection Method for Glyphosate, Glufosinate-Ammonium, and Aminomethyl Phosphoric Acid in Tea and Its Use for Risk Exposure Assessment

Wang

Gao

et al. 2021

J. Agric. Food Chem.

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The tea shrub is grown in long-standing orchards, an environment that is suitable for persistent weed growth, which is increasingly controlled by herbicides. Therefore, there is increasing concern that tea consumers may be exposed to herbicide residues. In this study, the levels of glufosinate-ammonium (GLU), glyphosate [N-(phosphonomethyl) glycine; PMG], and its metabolite aminomethyl phosphoric acid (AMPA) were determined in tea samples by HPLC–MS/MS using several current purification methods and a new method that we developed herein. The matrix effect of our proposed method was between -27.3 and 27.7%, which was lower than that in other methods, indicating that this method effectively reduced the interference of tea matrix in the mass spectrometry process. This method was used to determine the levels of PMG, GLU, and AMPA in 780 samples, including six traditional Chinese teas (green tea, black tea, oolong tea, dark tea, white tea, and yellow tea) and a floral tea, from 14 provinces of China. Probability estimates showed that the 95th percentile risk entropy values of the three pesticide residues were far below the acceptable risk level. The risk assessment results showed that exposure to PMG, GLU, and AMPA caused by drinking tea beverages poses no significant risk to human health.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Establishment of a HPLC–MS/MS Detection Method for Glyphosate, Glufosinate-Ammonium, and Aminomethyl Phosphoric Acid in Tea and Its Use for Risk Exposure Assessment

Wang

Gao

et al. 2021

J. Agric. Food Chem.

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“…Faced with this challenge, agricultural pest control has focused on the use of synthetic insecticides over the past decades (Badran et al, 2016; Bel et al, 2019). However, its overuse and indiscriminate use have brought several environmental problems, contaminating groundwater, and compromising the food chain with consequences for human health (Campos et al, 2019; Pardo‐López et al, 2013; Sousa et al, 2020). Besides the toxicity of these pesticides to nontarget individuals, resistant pest insects have been selected, calling attention to the urgent search for control alternatives (Coelho et al, 2020; Tavares et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Intestinal proteases profiling from Anticarsia gemmatalis and their binding to inhibitors

Silva-junior

Cabrera

Barbosa

et al. 2021

Arch Insect Biochem Physiol

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Although the importance of intestinal hydrolases is recognized, there is little information on the intestinal proteome of lepidopterans such as Anticarsia gemmatalis. Thus, we carried out the proteomic analysis of the A. gemmatalis intestine to characterize the proteases by LC/MS. We examined the interactions of proteins identified with protease inhibitors (PI) using molecular docking. We found 54 expressed antigens for intestinal protease, suggesting multiple important isoforms. The hydrolytic arsenal featured allows for a more comprehensive understanding of insect feeding. The docking analysis showed that the soybean PI (SKTI) could bind efficiently with the trypsin sequences and, therefore, insect resistance does not seem to involve changing the sequences of the PI binding site. In addition, a SERPIN was identified and the interaction analysis showed the inhibitor binding site is in contact with the catalytic site of trypsin, possibly acting as a regulator. In addition, this SERPIN and the identified PI sequences can be targets for the control of proteolytic activity in the caterpillar intestine and serve as a support for the rational design of a molecule with greater stability, less prone to cleavage by proteases and viable for the control of insect pests such as A. gemmatalis.

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“…Because of low toxicity to mammalian cells, high insecticidal efficacy, low environmental persistence, and relatively low potential to induce resistance of insects, the pyrethroid compounds are represented by 20% of the World’s insecticide markets [ 9 ]. The hydrophobic characteristic of pyrethroid compounds not only causes the tight binding with soil organic matter and particles, but also prevents the passage of these compounds to groundwater and thus forming residues that ultimately decrease soil fertility, hinder plant growth, and disturb the soil microbiota [ 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluate the Toxicity of Pyrethroid Insecticide Cypermethrin before and after Biodegradation by Lysinibacillus cresolivuorans Strain HIS7

Saied

Fouda

Alemam

et al. 2021

Plants

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Herein, bacterial isolate HIS7 was obtained from contaminated soil and exhibited high efficacy to degrade pyrethroid insecticide cypermethrin. The HIS7 isolate was identified as Lysinibacillus cresolivuorans based on its morphology and physiology characteristics as well as sequencing of 16S rRNA. The biodegradation percentages of 2500 ppm cypermethrin increased from 57.7% to 86.9% after optimizing the environmental factors at incubation condition (static), incubation period (8-days), temperature (35 °C), pH (7), inoculum volume (3%), and the addition of extra-carbon (glucose) and nitrogen source (NH4Cl2). In soil, L. cresolivuorans HIS7 exhibited a high potential to degrade cypermethrin, where the degradation percentage increased from 54.7 to 93.1% after 7 to 42 days, respectively. The qualitative analysis showed that the bacterial degradation of cypermethrin in the soil was time-dependent. The High-Performance Liquid Chromatography (HPLC) analysis of the soil extract showed one peak for control at retention time (R.T.) of 3.460 min and appeared three peaks after bacterial degradation at retention time (R.T.) of 2.510, 2.878, and 3.230 min. The Gas chromatography–mass spectrometry (GC–MS) analysis confirmed the successful degradation of cypermethrin by L. cresolivuorans in the soil. The toxicity of biodegraded products was assessed on the growth performance of Zea mays using seed germination and greenhouse experiment and in vitro cytotoxic effect against normal Vero cells. Data showed the toxicity of biodegraded products was noticeably decreased as compared with that of cypermethrin before degradation.

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Chemistry and Toxicology Behind Insecticides and Herbicides

Cited by 16 publications

References 152 publications

Establishment of a HPLC–MS/MS Detection Method for Glyphosate, Glufosinate-Ammonium, and Aminomethyl Phosphoric Acid in Tea and Its Use for Risk Exposure Assessment

Establishment of a HPLC–MS/MS Detection Method for Glyphosate, Glufosinate-Ammonium, and Aminomethyl Phosphoric Acid in Tea and Its Use for Risk Exposure Assessment

Intestinal proteases profiling from Anticarsia gemmatalis and their binding to inhibitors

Evaluate the Toxicity of Pyrethroid Insecticide Cypermethrin before and after Biodegradation by Lysinibacillus cresolivuorans Strain HIS7

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