Chemistry and Biological Activity of Essential Oils from <i>Piper Claussenianum</i> (Piperaceae)

Marques, André M.; Barreto, Anna Léa Silva; Batista, Eber M; Curvelo, José Alexandre Da Rocha; Velozo, Leosvaldo S. M.; Moreira, Davyson de Lima; Guimarães, Elsie Franklin; Soares, R. Félix; Kaplan, Maria Auxiliadora Coelho

doi:10.1177/1934578x1000501131

Cited by 30 publications

(28 citation statements)

References 23 publications

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“…Nerolidol is a major component in several essential oils (Marques et al, ) that possesses various pharmacological properties, such as its antitumor, leishmanicidal, and antischistosomal activities (Arruda et al, ; Silva et al, ; Wattenberg, ). In addition, nerolidol is usually used in cosmetics as a fragrance (Yingngam and Brantner, ).…”

Section: Introductionmentioning

confidence: 99%

Nerolidol Protects Against LPS-induced Acute Kidney Injury via Inhibiting TLR4/NF-κB Signaling

et al. 2017

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Acute kidney injury (AKI) is a critical care syndrome, resulting in acute reduction of renal function and up to 22% mortality of hospitalized patients. Nerolidol is a major component in several essential oils that possesses various pharmacological properties. The present study aimed to investigate the potential effect of nerolidol on lipopolysaccharide (LPS)-induced AKI. Nerolidol dose-dependently reduced the pathological injuries of kidney induced by LPS in rats. Nerolidol significantly decreased the levels of blood urea nitrogen and creatinine in LPS-treated rats in a dose-dependent manner. In addition, nerolidol inhibited LPS-induced decrease of cell viability in NRK-52E rat proximal tubular cells, which effect was concentration dependent. Nerolidol notably inhibited the increase of TNFα and IL-1β in LPS-treated rats and the mRNA expression of TNFα and IL-1β in LPS-treated NRK-52E cells. Nerolidol suppressed the increase of toll-like receptor 4 (TLR4) expression, phosphorylation and nuclear translocation of p65 NF-κB in kidneys of LPS-treated rats and LPS-treated NRK-52E cells. Overexpression of TLR4 and p65 NF-κB significantly suppressed nerolidol-induced inhibition of TNFα and IL-1β expression and increase of cell viability in LPS-treated cells. In summary, we found that nerolidol played a critical anti-inflammatory effects through inhibition of TLR4/NF-κB signaling and protected against LPS-induced AKI. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 99%

Nerolidol Protects Against LPS-induced Acute Kidney Injury via Inhibiting TLR4/NF-κB Signaling

et al. 2017

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“…However, limited information is known in the literature regarding the tissue‐wise detailed systematic investigation of the essential oil yield and composition for the majority of Piper species. Essential oil from the reproductive parts has been investigated only for a few Piper species such as P. marginatum and P. claussenianum …”

Section: Resultsmentioning

confidence: 99%

“…Essential oil from the reproductive parts has been investigated only for a few Piper species such as P. marginatum and P. claussenianum. 37,38…”

Section: Essential Oil Yield Of P Betleoidesmentioning

confidence: 99%

Piper betleoides C. DC.: Edible source of betel‐scented sesquiterpene‐rich essential oil

Kemprai

Bora

Mahanta

et al. 2019

Flavour & Fragrance J

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Betel leaf or ‘Paan’ (Piper betle) is an integral component of the addictive chewing stimulant ‘betel quid’ which is traditionally consumed by a large population in the Asian countries. Betel essential oil is also heavily used by the flavour industries. Often, it constitutes of carcinogenic and genotoxic phenylpropanoids. High incidence of the oral carcinogenesis in this part of the world has been linked to the chewing of betel quid as well as Paan. In this study, Piper betleoides C. DC. (wild Paan) was identified as the edible plant source from north‐east India possessing betel‐scented essential oil which was highly rich in sesquiterpenoids majorly germacrene D and β‐caryophyllene. Identity of the plant was confirmed through critical taxonomic studies. Further, the essential oil yield and composition were investigated across different vegetative (young and mature leaves, stem) and reproductive (male and female inflorescence) tissues of P. betleoides through gas chromatography‐mass spectrometry (GC‐MS) and nuclear magnetic resonance (1H, 13C NMR) spectroscopic analyses. The comparative quantitative investigation showed a high dominance by sesquiterpenoids (>90%) in the leaves of P. betleoides with no detection of phenylpropanoids. On the contrary, a high level of phenylpropanoids (>75%) was found in P. betle (Bangla Paan). In effect, P. betleoides can be a potential alternative source of betel‐scented sesquiterpene‐rich essential oil.

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“…Our group recently showed that the leaf essential oil from Piper claussenianum was able to inhibit the growth of L. amazonensis promastigotes with an IC 50 of 0.0038% (Marques et al, 2010). Trans-nerolidol is a major component of this essential oil.…”

Section: Anti-leishmanial Compoundsmentioning

confidence: 99%

Conventional Therapy and Promising Plant-Derived Compounds Against Trypanosomatid Parasites

Alviano¹,

Barreto²,

Dias³

et al. 2012

Front. Microbio.

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Leishmaniasis and trypanosomiasis are two neglected and potentially lethal diseases that affect mostly the poor and marginal populations of developing countries around the world and consequently have an important impact on public health. Clinical manifestations such as cutaneous, mucocutaneous, and visceral disorders are the most frequent forms of leishmaniasis, a group of diseases caused by several Leishmania spp. American trypanosomiasis, or Chagas disease, is caused by Trypanosoma cruzi, a parasite that causes progressive damage to different organs, particularly the heart, esophagus, and lower intestine. African trypanosomiasis, or sleeping sickness, is caused by Trypanosoma brucei and is characterized by first presenting as an acute form that affects blood clotting and then becoming a chronic meningoencephalitis. The limited number, low efficacy, and side effects of conventional anti-leishmania and anti-trypanosomal drugs and the resistance developed by parasites are the major factors responsible for the growth in mortality rates. Recent research focused on plants has shown an ingenious way to obtain a solid and potentially rich source of drug candidates against various infectious diseases. Bioactive phytocompounds present in the crude extracts and essential oils of medicinal plants are components of an important strategy linked to the discovery of new medicines. These compounds have proven to be a good source of therapeutic agents for the treatment of leishmaniasis and trypanosomiasis. This work highlights some chemotherapeutic agents while emphasizing the importance of plants as a source of new and powerful drugs against these widespread diseases.

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Chemistry and Biological Activity of Essential Oils from Piper Claussenianum (Piperaceae)

Cited by 30 publications

References 23 publications

Nerolidol Protects Against LPS-induced Acute Kidney Injury via Inhibiting TLR4/NF-κB Signaling

Nerolidol Protects Against LPS-induced Acute Kidney Injury via Inhibiting TLR4/NF-κB Signaling

Piper betleoides C. DC.: Edible source of betel‐scented sesquiterpene‐rich essential oil

Conventional Therapy and Promising Plant-Derived Compounds Against Trypanosomatid Parasites

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