Chemisorption of proteins and their thiol derivatives onto gold surfaces: characterization based on electrochemical nonlinearity

Nakata, Satoshi; Kido, Naoko; Hayashi, Momoko; Hara, Masahiko; Sasabe, Hiroyuki; Sugawara, Takashi; Matsuda, Takehisa

doi:10.1016/s0301-4622(96)02208-9

Cited by 44 publications

(50 citation statements)

References 23 publications

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“…5 As an application of the spontaneous oscillatory system, we have developed a nonlinear impedance method. 6,7,[9][10][11] The principle of this method is that a sinusoidal potential is applied to the electrode system, and the output current is analyzed by FFT. A platinum wire (length: 25 mm, diameter: 0.5 mm) was used as the working electrode and a Ag/AgCl electrode was used as the reference electrode.…”

Section: ·1 Electrochemical Sensor Based On Nonlinearity 3·1·1 Applimentioning

confidence: 99%

“…We reported that the voltage-dependent capacitance and resistance were characteristically changed depending on (1) without a surfactant 6,7 and (2) dynamic adsorption processes and the adsorption state of proteins on the platinum electrode. [9][10][11] In a related system, we developed an electrochemical sensor to detect the electrochemical nonlinearity as a deformation of the phase portrait of the input and output electrical signals by the use of "entrainment" between nonlinear oscillators. 8 The mode of entrainment was theoretically reproduced by numerical simulations based on nonlinear differential equations.…”

Section: ·1 Electrochemical Sensor Based On Nonlinearity 3·1·1 Applimentioning

confidence: 99%

“…As an application of this system, we have developed electrochemical oscillatory sensors driven by voltage perturbation. [6][7][8][9][10][11] We have also been developing a gas-sensory system under temperature or diffusion modulation 12 [22][23][24] Especially, the competition effect between the sensor responses to gaseous mixtures on a semiconductor gas sensor was discussed in relation to a theoretical simulation. Investigations by other researchers on the use of a time-dependent sensor response are also reviewed.…”

Section: Introductionmentioning

confidence: 99%

“…Figure 2 shows a schematic representation of a measurement for detecting and evaluating the nonlinearity of a system. Experimental and analytical profiles are as follows: [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] (1) a sinusoidal perturbation (X: e.g., temperature, voltage, flow rate, or surface area) is applied to the experimental system; (2) the output signal is recorded; and (3) a time trace of the output signal (Y) is Fourier transformed to the frequency domain. The deformation of the output signal from the sinusoidal input corresponds to the nonlinearity of the experimental system, and is quantitatively evaluated as higher harmonics of a Fourier transformation.…”

Section: Introductionmentioning

confidence: 99%

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Chemical Sensor Based on Nonlinearity: Principle and Application

2001

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Novel chemical sensors based on a time-dependent nonlinear response are reviewed. The strategy is to artificially mimic information transduction in living organisms. In taste and olfaction, information of chemical structure and concentration is transformed into nervous impulses in the nervous cell, i.e., time-dependent multi-dimensional information. Because the excitation and pulse generation in the nervous cell are typically nonlinear phenomena, it may be worthwhile to utilize the nonlinearity as the multi-dimensional information for molecular recognition. The principle of a "nonlinear" sensor is that a sinusoidal modulation is applied to a system, and the output signal is analyzed. The output signal of the sensor is characteristically deformed from the sinusoidal input depending on the chemical structure and concentration of the chemical stimuli. The characteristic nonlinear responses to chemical stimuli are discussed in relation to the kinetics of chemical compounds on the sensor surface. As a practical application, we introduced electrochemical sensors based on the differential capacitance, semiconductor gas sensors under the application of sinusoidal temperature or diffusion change, and a chemical sensor based on the spatio-temporal information. We demonstrated that mutli-dimensional information based on nonlinearity can provide quite useful information for the analysis of chemical species, even in the presence of another analyte or an interference with a single detector.

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Section: ·1 Electrochemical Sensor Based On Nonlinearity 3·1·1 Applimentioning

confidence: 99%

Section: ·1 Electrochemical Sensor Based On Nonlinearity 3·1·1 Applimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chemical Sensor Based on Nonlinearity: Principle and Application

2001

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“…Hence, measuring harmonics of f 0 can lead to information about the voltage dependence of the impedance. This measurement approach has been sparingly used in biosensors to date [6]. One practical difficulty is that the harmonic tones are widely spaced.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous measurement of nonlinearity and electrochemical impedance for protein sensing using two-tone excitation

Daniels

Anderson

Lee

et al. 2008

2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Impedance biosensors detect the binding of a target to an immobilized probe by quantifying changes in the impedance of the electrode-electrolyte interface. The interface's I-V relationship is inherently nonlinear, varying with DC bias, and target binding can alter the degree of nonlinearity. We propose and demonstrate a method to simultaneously measure the nonlinearity and conventional small-signal impedance using intermodulation products from a two-tone input. Intermodulation amplitudes accurately reflect the impedance's manually-measured voltage dependence. We demonstrate that changes in nonlinearity can discriminate protein binding. Our measurements suggest that target binding can alter nonlinearity via the voltage dependence of the ionic double layer.

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Impedance‐Spectroscopy Modifications

Lvovich¹

2012

Impedance Spectroscopy

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Chemisorption of proteins and their thiol derivatives onto gold surfaces: characterization based on electrochemical nonlinearity

Cited by 44 publications

References 23 publications

Chemical Sensor Based on Nonlinearity: Principle and Application

Chemical Sensor Based on Nonlinearity: Principle and Application

Simultaneous measurement of nonlinearity and electrochemical impedance for protein sensing using two-tone excitation

Impedance‐Spectroscopy Modifications

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