Chemische Konstitution und teratogene Wirkung in einigen Verbindungsgruppen

Kreybig, Th. von

doi:10.1007/bf00537064

Cited by 13 publications

(4 citation statements)

References 1 publication

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“…Methylurea and ethylurea without nitrite failed to induce lung adenomas, in agreement with a previous report on ethylurea (12). Methylurea is not teratogenic (19).…”

Section: Discussionmentioning

confidence: 92%

Nitrosamide Formation <italic>In Vivo</italic>: Induction of Lung Adenomas in Swiss Mice by Concurrent Feeding of Nitrite and Methylurea or Ethylurea<xref ref-type="fn" rid="FN2">2</xref>

Mirvish

Greenblatt

Kommineni

1972

JNCI: Journal of the National Cancer Institute

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Swiss mice were treated For 6 months with methylurea (5.36 g/kg Food) or ethylurea (6.36 g/kg Food) together with sodium nitrite (1.0 g/Iiter drinking water). In both groups, more than 4 lung adenomas/mouse were induced. The alkyl urea-plus-nitrite groups also had a small increase in malignant lymphomas. Similar treatment with methylurea or ethyl urea alone had no effect. The results indicate that the lung adenomas were induced by methylnitrosourea and ethylnitrosourea, Formed by in vivo nitrosation of the corresponding alkylureas. The possible public health implications of ureide nitrosation in vivo are discussed.

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“…Methylurea and ethylurea without nitrite failed to induce lung adenomas, in agreement with a previous report on ethylurea (12). Methylurea is not teratogenic (19).…”

Section: Discussionmentioning

confidence: 92%

Nitrosamide Formation <italic>In Vivo</italic>: Induction of Lung Adenomas in Swiss Mice by Concurrent Feeding of Nitrite and Methylurea or Ethylurea<xref ref-type="fn" rid="FN2">2</xref>

Mirvish

Greenblatt

Kommineni

1972

JNCI: Journal of the National Cancer Institute

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“…Another early study in rats (Kreybig, 1967) it was reported that SEM, given by i.p. injection on gestation days 10-13 at a dose of 140 mg/kg bw/day, had no adverse effect on embryonic development.…”

Section: Intraperitoneal Studiesmentioning

confidence: 99%

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Semicarbazide in food

2005

EFSA Journal

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“…Prolonged treatment may cause bone marrow depression, and may induce megaloblastosis [2, 131. In teratogenicity experiments, HU caused a reduction in the overall population and impaired haemopoiesis in the foetuses of rats treated late in pregnancy [8,14]. Phase-specific malformations were noted in rat foetuses examined shortly before term [6,9,10,12,[14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Effects of hydroxyurea on postnatal growth and behaviour of rats

Fritz

Hess

1980

Agents and Actions

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Hydroxyurea was administered intraperitoneally to pregnant albino rats in a single dose of 2000 mg/kg on day 14 of gestation. Both the perinatal and postnatal mortality rates of the progeny were increased and their weight gain reduced. Exploratory locomotion of 32-day-old rats, calculated by means of an 'activity index', was significantly reduced. The treatment had no effect on the brain weight. The fertility of the progeny was not impaired.

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Chemische Konstitution und teratogene Wirkung in einigen Verbindungsgruppen

Cited by 13 publications

References 1 publication

Nitrosamide Formation <italic>In Vivo</italic>: Induction of Lung Adenomas in Swiss Mice by Concurrent Feeding of Nitrite and Methylurea or Ethylurea<xref ref-type="fn" rid="FN2">2</xref>

Nitrosamide Formation <italic>In Vivo</italic>: Induction of Lung Adenomas in Swiss Mice by Concurrent Feeding of Nitrite and Methylurea or Ethylurea<xref ref-type="fn" rid="FN2">2</xref>

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Semicarbazide in food

Effects of hydroxyurea on postnatal growth and behaviour of rats

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