ChemInform Abstract: δ‐Carbolines and Their Ring‐Opened Analogues: Synthesis and Evaluation Against Fungal and Bacterial Opportunisitic Pathogens.

Abstract

δ-Carbolines and Their Ring-Opened Analogues: Synthesis and Evaluation Against Fungal and Bacterial Opportunisitic Pathogens. -A variety of substituted δ-carbolinium analogues (VIII) (10 examples) of the natural product cryptolepine is designed and synthesized. The δ-carbolinium salts display markedly higher antifungal and antibacterial activities and several-fold lower cytotoxicity than the natural alkaloid. The previously reported ring-opened analogues of (VIII) show antibacterial activities similar to their δ-carbolinium counterparts. -(MAZU, T. K.; ETUKALA, J. R.; JACOB, M. R.; KHAN, S. I.; WALKER, L. A.; ABLORDEPPEY*, S. Y.; Eur. J. Med. Chem. 46 (2011) 6, 2378-2385, http://dx.