ChemInform Abstract: β‐Lactam Derivatives as Potential Anticancer Compounds.

Abstract

Azetidine derivatives R 0045 β-Lactam Derivatives as Potential Anticancer Compounds. -A variety of β-lactam derivatives such as 1,4-diaryl-3-methylene-β-lactams (III)/(IV) and related addition products [cf. (VIII), (IX)] is synthesized and evaluated for antitumor activity. Some of them display excellent antitumor activities. -(RUF, S.; NEUDERT, G.; GUERTLER, S.; GRUENERT, R.; BEDNARSKI, P. J.; OTTO*, H.-H.; Monatsh. Chem. 139 (2008) 7, 847-857; Inst. Pharm./Med. Chem., Ernst-Moritz-Arndt-Univ.,