ChemInform Abstract: Vasodilating and Antiarrhythmic Activity of Heteryl Lactones.

Abstract

Vasodilating and Antiarrhythmic Activity of Heteryl Lactones.-A new series of unsaturated γ-and δ-lactones (III) and (VI), resp., with pyridyl, quinolyl, and nitrophenyl substituents is synthesized by base-catalyzed aldol condensation reactions and their antiarrhythmic, vasodilating, and cardiotonic activities are evaluated in vivo and ex vivo.

Reactions of 5-(4-methoxy-3-methylphenyl)-2(3H)-furanone with some electrophilic and nucleophilic reagents

“…Compounds incorporating such heterocycles in their structure have been found to display broad spectrum of biological activities including anti-inflammatory [1][2][3], cardiotonic activity [4], analgesic [5], anticancer [6], anti-convulsant [7], anti-microbial [8] and antiviral activeties [9].…”

Synthesis of quinoline attached-furan-2(3H)-ones having anti-inflammatory and antibacterial properties with reduced gastro-intestinal toxicity and lipid peroxidation

“…14, 22 Calculations of δ-values using incremental parameters for the hydrogen (semi- cyclic double bond) suggested the (E)-configuration. All the synthesized compounds were characterized by spectroscopic data, i.e., IR, 1 H-NMR, 13 C-NMR and mass, and elemental analysis. The results are given in the supplementary material to this paper.…”

Synthesis, structure and biological activity of new 6,6‐dimethyl‐2‐oxo‐4‐{2‐[5‐organylsilyl(germyl)]furan(thiophen)‐2‐yl}vinyl‐5,6‐dihydro‐2H‐pyran‐3‐carbonitriles

“…The derivatives of 5,6‐dihydro‐2 H ‐pyrane, 6,6‐dimethyl‐2‐oxo‐5,6‐dihydro‐2 H ‐pyran‐3‐carbonitrile and structurally related compounds have shown a wide range of biological activities, which makes this family of great interest in the biomedical field since it might provide potential cardiovascular, neurotropic and anticancer‐active substances . Also, it is well known that the introduction of silyl‐ and germyl‐type substituents into the molecules of biologically active compounds often results in dramatic alteration and improvement of their biological properties .…”