ChemInform Abstract: UMAETHIERUNG VON 2‐ALKYLMERCAPTO‐PYRIMIDINEN

Abstract

Durch eine 1‐5stündige Reaktion der Methylmercapto‐ bzw. Äthylmercaptopyrimidone (I) mit einem 1,5fachen Überschuß der Mercaptane (II) in Gegenwart von Triäthylamin oder Na‐äthylat in siedendem Äthanol lassen sich die Sulfide (III) (Ausbeute 50‐100%) darstellen.

An unexpected conversion of methyl (5-bromo-6-methyl-2-methylsulfanyl-4-oxo-3,4-dihydro-3-pyrimidinyl)acetate on reaction with methyl sulfanylacetate

“…The structure of the latter was confirmed by obtaining product 6 from compound 5 and the previously synthesized compound 7 [3]. The compounds obtained appeared to be products of transesterification of the ester groups and substitution of the 2-methylsulfanyl group by ethoxy or hydroxy groups (compounds 3 and 4) and also scission of the exocyclic S-C bond (compound 5).…”