ChemInform Abstract: Tricyclic Heteroaromatic Systems. Synthesis and Benzodiazepine Receptor Affinity of 2‐Substituted‐1‐benzopyrano[3,4‐d]oxazol‐4‐ones, ‐thiazol‐4‐ones, and ‐imidazol‐4‐ones.

Abstract

Tricyclic Heteroaromatic Systems. Synthesis and Benzodiazepine Receptor Affinity of 2-Substituted-1-benzopyrano[3,4-d]oxazol-4-ones, -thiazol-4-ones, and -imidazol-4-ones.-A number of benzopyranooxazolone [cf. (III), (V)], -thiazolone [cf. (IX)], and -imidazolone [cf. (XIII)] derivatives are synthesized from appropriate functionalized coumarin derivatives. None of tested heterocycles displays detectable affinity for the benzodiazepine receptor. -(COLOTTA, V.; CATARZI, D.; VARANO, F.; CECCHI, L.; FILACCHIONI, G.; MARTINI, C.; GIUSTI, L.; LUCACCHINI, A.; Farmaco 53 (1998) 5, 375-381; Dip. Sci. Farm., Univ. Firenze, I-50121 Firenze, Italy; EN)