ChemInform Abstract: Transesterification of Trimethyl Orthoacetate: An Efficient Protocol for the Synthesis of 4‐Alkoxy‐2‐aminothiophene‐3‐carbonitriles.
Abstract:Synthesis of 4-Alkoxy-2-aminothiophene-3-carbonitriles. -A facile protocol for the synthesis of functionalized title compounds (IV) (16 examples) involves transesterification of substrates with higher alcohols, subsequent reaction with dinitrile and final Gewald reaction. No reaction takes place with a tertiary alcohol. The process can also be used for the preparation of some amino analogues of type (VI). -(RAO, K. V.; BALAKUMAR, C.; NARAYANA, B. L.; KISHORE, D. P.; RAJWINDER, K.; RAO*, A. R.; Tetrahedron Lett… Show more
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